Blood
Articles in this Issue
Role of NK cells in immune escape in patients with classical paroxysmal nocturnal hemoglobinuria
Abstract Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder. Immune escap...
Clinical benefit of luspatercept in erythropoiesis-stimulating agent (ESA)-naive patients (pts) with early disease characteristics and very low-, low-, or intermediate-risk Myelodysplastic Syndromes (LR-MDS): A post hoc analysis from the commands trial
Abstract Background: In the phase 3 COMMANDS trial (NCT03682536) evaluating pts with ESA-naive transfusion-dependent (TD...
Redefining the myeloid disease continuum: Machine learning–based development and validation of an integrated multimodal classification of myeloid neoplasms
Abstract Introduction The 2022 WHO/ICC classifications of myeloid neoplasms (MNs) incorporated genomics into the existing clinicopathologic...
Piezo1-mediated mechanosensation in bone marrow macrophages promotes hematopoietic support function of BM-MSCs in a CD105-dependent manner
Abstract Background: Hematopoietic reconstitution following high-dose radiotherapy and chemotherapy is closely regulated by the hematopoieti...
From efficacy to experience: 52-week patient-reported outcomes with Mim8 in adolescents and adults with hemophilia A with or without inhibitors (FRONTIER2)
Abstract Introduction Mim8 is a new-generation, bispecific antibody, activated factor VIII mimetic in clinical developme...
Deep learning enables automated quantification of hematopoietic stem and progenitor cells (HSPCs) in zebrafish embryos
Abstract Acute myeloid leukemia (AML) is a malignancy of hematopoietic stem and progenitor cells (HSPCs), characterized by the unchecked pro...
Phase II study of polatuzumab in combination with chemoimmunotherapy for richter transformation (PolaR-EPCH).
Abstract Background: Richter transformation (RT) is a rare complication observed in patients (pts) with chronic lymphocytic leukemia/small l...
“efficacy and safety of treosulfan- vs. busulfan-based conditioning regimens in adult allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes and acute myeloid leukemia: A systematic review and meta-analysis.”
Abstract Background: Treosulfan has emerged as a potentially less toxic alternative to busulfan in conditioning regimens for allogeneic hema...
The single-cell transcriptomic dissection analysis: Platelet-t cell/macrophage crosstalk and immune imbalance in aplastic anemia (AA)
Abstract Background the pathogenesis of HSPCs impairment in aplastic anemia (AA) remains unclear. In this study, in addition to focusing on C...
The fanconi anemia pathway restrains MLL-rearranged leukemogenesis through suppressing NHEJ-mediated genomic instability
Abstract Genetic rearrangements involving the mixed lineage leukemia (MLL) gene give rise to MLL-rearranged (MLL-r) leukemia, which compromi...
Bendamustine, gemcitabine, and vinorelbine (BeGEV) regimen followed by ASCT Induces Durable Remissions in PD-(L)1 inhibitor-resistant Refractory/relapsed classical Hodgkin lymphoma: A single-center, long-term study
Abstract Background Primary refractory or relapsed disease occurs in 20–40% of classical Hodgkin lymphoma (cHL) patients after first-line th...
Correlative data from an ongoing Phase 1, multicenter study of senti-202, a first-in-class, CD33 and/or FLT3 & not endomucin (EMCN), selective off-the-shelf CAR NK cell therapy for Acute Myeloid Leukemia (AML) is consistent with its clinical activity and unique logic gated mechanism of action
Abstract SENTI-202 is being evaluated in an ongoing Phase I clinical trial, SENTI-202-101 (NCT06325748). SENTI-202 selectively kills AML bla...
Acute Myeloid Leukemia-associated pneumonia mortality trends (1999–2023) and ARIMA-based projections through 2050 in geriatric u.S. adults
Abstract Introduction: Pneumonia is a prevalent and serious complication in acute myeloid leukemia (AML), affecting more than 25% of treated...
Application of machine learning to identify risk factors for 14-day emergency department return visits in pediatric sickle cell patients discharged after vaso-occlusive crises
Abstract Sickle cell disease (SCD) is a severe, chronic disease associated with frequent vaso-occlusive crises (VOC), leading to extreme pai...
Rethinking ferritin reference ranges for diagnosing iron deficiency at Denver health
Abstract Introduction Iron deficiency (ID) is a globally burdensome, yet highly treatable disease, affecting 2 billion total people worldwid...
Real-world outcomes of teclistamab for multiple myeloma in Canada: Multi-institutional report from the Canadian myeloma research group (CMRG) database
Abstract Introduction: Teclistamab is a highly effective treatment for relapsed multiple myeloma (MM), with an overall response rate (ORR) o...
Phase IB/II trial of epcoritamab plus ibrutinib in patients with relapsed/refractory aggressive B-cell non-Hodgkin lymphoma
Abstract Background: The CD3xCD20 bispecific antibody epcoritamab has shown significant clinical activity in relapsed/refractory large B-cel...
In severely injured civilian trauma patients, preemptive transfusion of low-titer group o+ non-leukoreduced whole blood promotes significantly improved 30-day survival
Abstract Introduction: Trauma is a major cause of death worldwide; yet, patients (pts) with traumatic hemorrhage are potentially salvageable...
Examining the utility of RBC transfusions in uncomplicated vaso-occlusive episodes
Abstract Vaso-occlusive episodes (VOE) are the leading cause of in-patient admissions in sickle cell disease (SCD). While RBC transfusions a...
Glp-1 receptor agonist use is associated with lower risk of progression from MGUS to SMM or MM in a large real-world cohort
Abstract Background: Monoclonal gammopathy of undetermined significance (MGUS) is a precursor to multiple myeloma (MM) and smoldering multip...
Zanubrutinib combined with intrathecal chemotherapy for prevention of CNS relapse in high-risk diffuse large B-cell lymphoma
Abstract Background: Secondary central nervous system lymphoma (SCNSL) in diffuse large B-cell lymphoma (DLBCL) carries...
Respiratory syncytial virus (RSV) infection in adults with blood cancer: An England-wide population study
Abstract Background The recent development of vaccines for respiratory syncytial virus (RSV) has created a pressing need to better quantify...
Outcomes of adolescent and young adult patients with AML treated on adult versus pediatric protocols
Abstract Background: Acute Myeloid Leukemia (AML) treatment in adolescent and young adult (AYA) patients (pts) may be challenging due to the...
Phase 1 assessment of novel transposon BAFF CAR-T cells (LMY-920) for non-Hodgkin lymphoma (NHL) and multiple myeloma (MM)
Abstract Background and Significance: Marked success has been achieved using scFv-based CAR-T cell therapies targeting CD19 and BCMA to trea...
Artificial intelligence (AI)–based membrane specific PD-L1 and immune subtypes as predictive biomarkers for danburstotug in relapsed or refractory extranodal NK/T cell lymphoma (R/R ENKTL): Insights from the Phase II trial (DISTINKT)
Abstract Introduction: Danburstotug has demonstrated promising efficacy in patients with R/R ENKTL. However, the relationship between PD-L1...