Blood
Articles in this Issue
Phenotyping of ex vivo expanded NK cells reveals unique transcriptomic and epigenetic signatures
Abstract Background: Natural Killer (NK) cells have powerful anti-tumor effects. NK cells expanded for adoptive transfer are commonly co-cul...
MRD-guided azacitidine maintenance improves outcomes in molecularly persistent pediatric core-binding factor AML: A retrospective cohort study
Abstract Background: Relapse remains a major challenge in pediatric acute myeloid leukemia (AML), particularly in non-transplant-eligible pa...
A-319, a CD3xCD19 T cell engager, monotherapy for patients with refractory/relapsed B-cell acute lymphoblastic leukemia (r/r B-ALL)
Abstract Introduction Blinatumomab has been approved to treat patients with B cell precursor acute lymphoblastic leukemia (B-ALL) with 28-da...
Association of platelet transfusion and clinical outcomes in chimeric antigen receptor T-cell therapy: Insights from a six-year nationwide analysis
Abstract Background Chimeric Antigen Receptor (CAR) T-cell therapy is an established treatment for relapsed or refractory non-Hodgkin's lymp...
A retrospective analysis of outcomes of high-risk myelodysplastic syndrome patients treated with upfront decitabine/cedazuridine versus hypomethylating agents with venetoclax utilizing real-world data
Abstract Background: High-risk myelodysplastic syndromes (HR-MDS) carry a poor prognosis, with median overall survival u...
Graft-versus-HIV-reservoir reactivity: Long term HIV remission after allogeneic stem cell transplantation from a donor with active CCR5
Abstract Background HIV cure is exceptionally rare and is documented in only six cases. All HIV cure cases were individu...
Reduced pulmonary function and posterior cerebral artery perfusion among Hodgkin lymphoma survivors.
Abstract Background/Purpose: Hodgkin Lymphoma (HL) survivors exposed to chest radiation and bleomycin are at increased risk for heart and lu...
CRS/ICANS Prophylaxis does not Improve Outcomes in adult patients with Relapsed/Refractory B-cell acute lymphoblastic leukemia (B-ALL) treated with brexucabtagene autoleucel
Abstract Introduction: CD19-directed CAR T-cell (CAR-T) therapy has substantially improved clinical outcomes for adults with relapsed or ref...
In-hospital outcomes of hyponatremia in non-Hodgkin lymphoma patients: Insights from a 7-year national cohort study
Abstract Background: Non-Hodgkin lymphoma (NHL) is one of the most common hematological malignancies in the United States with the mortality...
25-year trends in autoimmune neutropenia-related mortality in the United States: A national CDC wonder analysis (1999-2023)
Abstract Background: Autoimmune neutropenia (AIN) is a rare immune-mediated hematologic disorder characterized by periph...
A multimodal machine learning framework to predict treatment duration in multiple myeloma patients
Abstract Introduction:Artificial intelligence (AI) and machine learning (ML) are increasingly used in oncology to enable personalized treatm...
Efficacy and Safety of cladribine combined with cytarabine and G-CSF in Eliminating Measurable Residual disease for Core-binding factor acute myeloid leukemia: A retrospective, single-arm, multicenter study
Abstract Background Persistent measurable residual disease (MRD) in core-binding factor acute myeloid leukemia (CBF-AML) is closely associat...
Disaggregated outcomes of Asian Americans, Native Hawaiian and Pacific Islander populations with Acute Myeloid Leukemia
Abstract Introduction: Asian American, Native Hawaiian, and Pacific Islander (AANHPI) individuals represent one of the m...
High FDX1 expression enhances the sensitivity of multiple myeloma cells to elesclomol
Abstract Background:Copper is an essential micronutrient required for regular physiological functions in the body. Dysregulated copper metab...
Integrating genomic features for prognosis in Chinese patients with B-cell lymphoma following R-CHOP therapy
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Despite therapeutic advancemen...
Behind the blood-brain barrier: Contemporary screening practice patterns and trends of central nervous system involvement in acute myeloid leukemia treated with intensive regimens and hypomethylating agent/venetoclax
Abstract Background: Patients (pts) with newly diagnosed acute myeloid leukemia (AML) with WBC>40 x103/µL, FLT3-ITD/KD mutations (FLT...
Real-world clinical characteristics and outcomes of patients with myelodysplastic syndrome with TP53 mutation
Abstract Introduction: TP53 mutations (TP53m) are observed in ~10% of patients (pts) with myelodysplastic syndromes (MDS) and constitute a h...
Elevated serum erythropoietin level is associated with unique clinical and genomic features, response to treatment, and outcomes in lower-risk myelodysplastic syndromes
Abstract Introduction Elevated endogenous serum erythropoietin level (EPO) is a biomarker of erythropoiesis and is used in clinical practice...
Baseline clinical characteristics of patients with chronic lymphocytic leukemia (CLL) from 11 Latin American countries: A real-world registry analysis
Abstract Background: Chronic lymphocytic leukemia (CLL) exhibits diverse clinical manifestations, and access to diagnost...
A phase 2 trial of iberdomide, carfilzomib, daratumumab and dexamethasone quadruplet therapy for relapsed/refractory multiple myeloma: The rekindle study
Abstract Introduction Advances in newly diagnosed multiple myeloma (MM) have resulted in high rates of MRD- negativity independent of transp...
Evaluation of outcomes by line of therapy in marginal zone lymphoma: Real-world evidence from 10 US academic centers
Abstract Introduction: Marginal zone lymphoma (MZL) is an indolent B-cell non-Hodgkin lymphoma characterized by relapses over patients' (pts...
Cyclin D1 beyond the cell cycle: A new role in t(11;14) multiple myeloma
Abstract Cyclin D1, encoded by CCND1, is a cell cycle regulator, overexpressed in ~15% of multiple myeloma (MM) cases via CCND1::IGH super-e...
Clonal hematopoiesis drives T cell dysregulation and immune remodeling revealed by GWAS-based mendelian randomization and single-cell transcriptomics
Abstract Clonal hematopoiesis (CH), driven by somatic mutations in hematopoietic stem and progenitor cells (HSPCs), is associated with incre...
A phase 1/1b open-label, dose escalation, first-in-human study to evaluate the safety, tolerability, pharmacokinetics, and preliminary anti-leukemic activity of the orally available clk inhibitor, BH-30236, in adults with R/R AML or HR-MDS
Abstract Background: Dysregulated alternative splicing (AS) is hallmark of cancer which plays an important role in regulating proliferation,...
Sociodemographic and patient-related determinants of outcomes after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis
Abstract Background Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative therapy for several hematologic disorders. While...