Blood
Articles in this Issue
Impact of maintenance strategies post-autologous stem cell transplant in patients with newly diagnosed multiple myeloma and high-risk cytogenetic abnormalities
Abstract Introduction Outcomes for patients with newly diagnosed multiple myeloma (NDMM) who have high-risk cytogenetic...
Feasibility and utility of unmatched whole-genome sequencing (uWGS) for pediatric acute leukemias: An analysis of leukemia precision-based therapy (LEAP) study samples
Abstract Introduction For children with acute leukemias, rapid and accurate assessment of genomic biomarkers is essential for optimal diagno...
Targeting the casein kinase II /ikaros axis sensitizes TKI activity by suppression of GLUT1 expression and glycolysis in ph+ ALL
Abstract Background The survival rate of Philadelphia (Ph) chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) was significantly incre...
The molecular landscape of patients with malignant histiocytosis
Abstract Purpose. Malignant histiocytoses (MHs) including Langerhans cell sarcoma (LCS), interdigitating dendritic cell sarcoma (IDCS), and...
Early use of talicabtagene autoleucel in r/r B-acute lymphoblastic leukemia is cost-effective: Improved efficacy, reduced toxicity and healthcare resource utilization support affordable access
Abstract Background: In India, access to curative therapies for relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL) remains...
Inflammatory signaling selectively disrupts GATA factor-regulated networks governing erythroid differentiation and hemoglobin synthesis
Abstract Chronic inflammation, often associated with aging, instigates anemia of inflammation (AI) that afflicts hundreds of thousands in th...
Targets of BTK and IRAK4 pathways in cns lymphoma: Identification of CXCL10 as a prognostic biomarker in CSF and its receptor, CXCR3, as a mediator of pro-survival signaling
Abstract The pathogenesis of primary CNS lymphoma (PCNSL) is dependent upon constitutive activation of nuclear factor-kappa B (NF-kB) signal...
Prognostic impact of CXCR4 mutation type on clinical features and outcomes of patients with Waldenström macroglobulinemia
Abstract Introduction:Waldenström macroglobulinemia (WM), the most common subtype of lymphoplasmacytic lymphoma (LPL), is characterized by t...
Comparative evaluation of NGS-based MRD detection in AML using longitudinal matched bone marrow and blood samples
Abstract Background: Measurable residual disease (MRD) detection is a critical prognostic tool in acute myeloid leukemia (AML), guiding trea...
Breaking geographic barriers in a Mexican ambulatory transplant program: Early outcomes in a diverse national and international cohort
Abstract Background: Access to hematopoietic cell transplantation (HCT) in Latin America remains highly centralized. The lack of regional tr...
A combinatorial caar-T cell strategy to eliminate factor VIII inhibitors in preclinical models of Hemophilia A
Abstract Background Chimeric Autoantibody Receptor T (CAAR-T) cell therapy, an extension of chimeric antigen receptor T cell (CAR-T) technol...
Mediators of racial and ethnic inequities in access to front-line therapies for chronic lymphocytic leukemia in the United States: A real-world evidence study
Abstract Background The treatment (tx) landscape for chronic lymphocytic leukemia (CLL) has evolved, with National Comprehensive Cancer Netw...
Neonatal fc receptor antagonists in adult patients with primary immune thrombocytopenia: Systematic review and meta-analysis of randomized controlled trials
Abstract Introduction Primary immune thrombocytopenia (ITP) is an autoimmune condition marked by low platelet counts due to antibody-mediate...
Clinical, anatomic, and histologic determinants of gastrointestinal disease burden and survival in systemic AL amyloidosis: A cohort study of 560 patients
Abstract Background: Gastrointestinal (GI) symptoms are frequent in patients (pts) with systemic light chain amyloidosis (AL), yet their clin...
Novel prognostic scoring system for hematopoietic stem cell transplantation in myelodysplastic syndrome and Acute Myeloid Leukemia, myelodysplasia-related
Abstract Background: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative option for adva...
Outcomes of long-term anticoagulation use in patients hospitalized with sickle cell vaso-occlusive crisis: A weighted analysis of the national inpatient sample (2016–2022)
Abstract Background: Sickle cell disease is associated with both thrombotic and hemorrhagic complications, particularly during vaso-occlusiv...
Chick embryo xenograft model of multiple myeloma recapitulates immune response, systemic dissemination, and sensitivity to anti-myeloma therapeutics
Abstract Introduction Multiple myeloma (MM) is an incurable plasma cell cancer comprising ~2% of cancer diagnoses and 10% of hematologic mal...
Arvenacogene sanparvovec: A novel gene therapy for hemophilia B – results from A phase I–II first-in-human trial
Abstract Introduction: ANB-002 (INN: arvenacogene sanparvovec) is a gene construct for the therapy of hemophilia B. It utilizes an adeno-ass...
T-cell redirecting therapies in multiple myeloma: Barriers and knowledge gap among patients, community physicians, and caregivers
Abstract Background: T-cell redirecting therapies (TCRT), including CAR T-cell and bispecific antibodies have emerged as a new pillar of tre...
Global, regional, and national burden of myelodysplastic, myeloproliferative, and other hematopoietic neoplasms from 1990 to 2021, and projections to 2050: A systematic analysis for the global burden of disease study 2021
Abstract Background: Myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), and related hematopoietic neoplasms (collectively...
Initial experience with anti-CD19 CAR-T cell therapy in patients with Relapsed/Refractory diffuse large B-cell lymphoma in a brazilian cancer center
Abstract INTRODUCTION: Chimeric antigen receptor T-cell (CAR-T) therapy targeting CD19 has emerged as a promising therapeutic modality for p...
Determining barriers to access first-line treatment in high volume facilities in adolescents and young adults (AYA) with acute leukemias
Abstract Adolescents and young adults (AYA) with acute leukemias, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (A...
Non-invasive detection and classification of lymphoma via cell-free DNA methylation profiling
Abstract Diagnosing lymphoma relies on invasive tissue biopsies, which can yield insufficient material for histopathological evaluation and...
Bispecific antibody therapy in multiple myeloma is impaired by tumor-associated macrophages through dual immunosuppressive and antigen-dependent mechanisms
Abstract Multiple myeloma (MM) is a malignant plasma cell disorder primarily affecting the bone marrow. Advances such as proteasome inhibito...
A machine learning model to predict risk of infection in patients receiving bispecific antibody therapy for multiple myeloma
Abstract Background: Bispecific antibodies (bsAb) have revolutionized the care of patients with multiple myeloma (MM); however, they are als...