Blood
Articles in this Issue
Real‑world comparison of CAR‑T therapy versus bispecific antibodies in Relapsed/Refractory multiple myeloma
Abstract Introduction Chimeric-antigen-receptor T-cell (CAR-T) drugs include idecabtagene vicleucel and ciltacabtagene a...
Efficacy and safety of crizanlizumab in sickle cell disease : A systematic review and meta-analysis
Abstract Introduction: Sickle cell disease (SCD) is a debilitating hemoglobinopathy characterized by recurrent vaso-occlusive crises (VOCs),...
Higher helios⁺ treg levels pre- and post-CAR T infusion are associated with inferior outcomes in patients with LBCL
Abstract Background Regulatory T cells (Tregs) are key immunosuppressive cells in the tumor microenvironment that may impair CAR T-cell expa...
Venous thromboembolism in lymphoma: A scoping review of anticoagulation strategies and clinical outcomes
Abstract Background: Venous thromboembolism (VTE) is a leading cause of morbidity and mortality in lymphoma patients. The 2021 American Soci...
The potential factors associated with treatment outcomes in newly diagnosed elderly AML patients treated with first-line venaza therapy: A retrospective study
Abstract Objective In recent years, the combination of venetoclax with azacitidine (VenAza) has established itself as the standard first-lin...
An analysis of sickle cell disease content on tiktok
Abstract Introduction: Sickle cell disease (SCD) is a hereditary hemoglobinopathy affecting approximately 100,000 indivi...
Comparative analysis of CAR-T cell therapies across lymphoma subtypes: Efficacy, safety, and future perspectives
Abstract Background: Lymphomas are a heterogeneous group of malignancies arising from the clonal proliferation of B-cell, T-cell, and natura...
Assessing germline noncoding risk variants impacting clonal hematopoiesis using a massively parallel reporter assay
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) is a precursor state characterized by expansion of blood clones carrying som...
Eculizumab for hyperhemolysis syndrome in sickle cell disease: A systematic review and meta-analysis
Abstract Background Hyperhemolysis syndrome (HHS) is a rare, potentially fatal transfusion complication seen in...
CPX-351 is a feasible bridge to allogeneic hematopoietic stem cell transplantation in TP53 mutated acute myeloid leukemia with myelodisplastic related changes or therapy related without del(17p): Sub-analysis from a large italian real world retrospective study
Abstract CPX-351 has been approved for Acute Myeloid Leukemia (AML) with myelodysplasia related changes (AML-MRC) and therapy-related (t-AML...
TBI-ATG based conditioning regimen is a promising approach for adult patients with refractory and relapsed peripheral T cell lymphoma undergoing allogeneic peripheral blood stem cell transplantation
Abstract PTCL are a heterogeneous group of lymphoproliferative disorders generally associated with dismal clinical outcomes, especially in t...
Real-world data on breakthrough hemolysis in patients with paroxysmal nocturnal hemoglobinuria treated with proximal and terminal complement inhibitors.
Abstract Paroxysmal Nocturnal Hemoglobinuria (PNH) is a rare clonal disorder caused by a somatic mutation in the PIG-A gene. The resulting C...
CRISPR-Cas12a gene editing of the HBG1/2 promoters leads to sustained normalization of total hemoglobin and increased fetal hemoglobin in patients with severe sickle cell disease: Updated Results from the RUBY trial
Abstract Introduction: Elevated levels of fetal hemoglobin (HbF, α2γ2) can attenuate or eliminate symptoms in sickle cell disease (SCD), inc...
Mim8 prophylaxis in adults and adolescents with hemophilia A: 52-week efficacy and safety outcomes from the phase 3 FRONTIER2 study
Abstract Introduction Mim8 (denecimig) is a new-generation, bispecific antibody, activated factor VIII mimetic in clinic...
ZFP36L2 as a promising therapeutic target in acute graft-versus-host disease: Evidence from murine models and clinical validation
Abstract Introduction Acute graft-versus-host disease (aGVHD) remains a major cause of non-relapse mortality following allogeneic hematopoie...
A novel mass spectrometry approach for blood group antigen typing
Abstract Introduction Many blood group antigens beyond ABO and RhD are clinically important, especially in certain popul...
Management of heparin-induced thrombocytopenia in impella-supported cardiac surgery: A comprehensive four-patient case series with novel anticoagulation strategies
Abstract Background: Heparin-induced thrombocytopenia (HIT) complicates mechanical circulatory support with Impella devices, creating a para...
A deep learning model to dynamically predict cancer-associated thrombosis using electronic health records from the u.s. veterans affairs healthcare system
Abstract Background: Venous thromboembolism (VTE) is a potentially preventable complication in cancer patients undergoing systemic therapy....
Targeted deep sequencing of myeloma in a multi-institutional clinical workflow
Abstract Background: Fluorescence in situ hybridization (FISH) remains standard for multiple myeloma (MM) but is limited by probe scope and c...
Real-world hematologic response and treatment patterns among patients with polycythemia vera (PV) treated with ropeginterferon alfa-2b (ropeg)
Abstract BACKGROUND PV is a chronic myeloproliferative neoplasm characterized by elevated blood counts, especially erythrocytosis, and associ...
A prospective clinical study of venetoclax plus azacitidine for the maintenance treatment of post-remission Acute Myeloid Leukemia
Abstract Introduction Although acute myeloid leukemia (AML) patients often achieve remission after induction therapy, most patients eventuall...
Efficacy and safety of a fully human BCMA CAR T-cell therapy for high-risk newly diagnosed transplant-ineligible multiple myeloma: Updated results from an open label, single-arm，phase 1 study（fumanba-2）
Abstract Equecabtagene Autoleucel (Eque-cel, IASO Bio), as a fully human BCMA chimeric antigen receptor (CAR) T-cell therapy, received appro...
Single cell transcriptomics of matched cerebrospinal fluid and bone marrow patient samples highlights the role for CXCR4 in acute lymphoblastic leukemia CNS disease
Abstract Acute lymphoblastic leukemia (ALL) disseminates to the central nervous system (CNS) with high prevalence, and a very high proportio...
Ocular-adnexal non-Hodgkin lymphoma among hispanic Latino population: 18 years of experience
Abstract Background: Ocular-adnexal non-Hodgkin lymphoma (OANHL) is a rare lymphoid malignancy, accounting for only 1–2% of all non-Hodgkin...
Propensity score matched comparison of outcomes following treatment with pola-R-CHP versus R-CHOP for diffuse large B cell lymphoma patients captured in a real-world database
Abstract Background: Polatuzumab vedotin combined with R-CHP (Pola-R-CHP) has recently emerged as an alternative to R-CHOP for the frontline...