Blood
Articles in this Issue
Tumor flare pain reaction during teclistamab step-up dosing with tocilizumab prophylaxis: An underrecognized toxicity in the outpatient setting
Abstract Background: Teclistamab is a BCMA-directed bispecific antibody approved for the treatment of relapsed and refractory multiple myelo...
“upfront use of blinatumomab in adolescents and adults with Philadelphia Chromosome–Negative B-cell acute lymphoblastic leukemia: A systematic review and proportional meta-analysis”
Abstract Background: Philadelphia chromosome–negative (Ph–) ALL is a genetically heterogeneous entity defined by recurrent cytogenetic and m...
Impact of minimal residual disease outcomes with ciltacabtagene autoleucel in cartitude-4: Oncologist treatment preferences in lenalidomide-refractory multiple myeloma
Abstract Introduction: Despite therapeutic advances in relapsed/refractory multiple myeloma (RRMM), optimal sequencing remains a clinical ch...
Real-world evidence from China: Clinical characteristics, treatment landscape and long-term outcomes in 566 autoimmune hemolytic anemia patients
Abstract Objective: Autoimmune hemolytic anemia (AIHA) is the most prevalent form of acquired hemolytic anemia, representing a heterogeneous...
Tracing the evolution of clonal T cell responses in LGL leukemia with single-cell whole genome sequencing
Abstract Background T cell large granular lymphocytic leukemia (T-LGLL) is a rare hematological disease of clonally expanded mature cytotoxic...
Distinct morphological features of malignant cells in large B-cell lymphoma identified by soft-segmentation in imaging-based spatial proteomics
Abstract Background: Mature B-cell neoplasms display densely packed and morphologically heterogeneous cells, often complicating tissue-level...
The clinical utility of MALDI-TOF MS in multiple myeloma
Abstract Introduction: Matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) can detect their mass-to-...
High incidence of impaired graft function after allogeneic HSCT for myelofibrosis, and successful utilization of stem cell boost
Abstract For myelofibrosis (MF) patient's undergoing hematopoietic stem cell transplant (HSCT) engraftment failure is a life-threatening cha...
ASTX727 delivers superior response rates and associated survival benefit versus hydroxycarbamide/best supportive care in CMML and other MDS/MPN overlap syndromes: First results from the Phase 2 UK multicenter randomized ammo trial
Abstract Background Chronic myelomonocytic leukemia (CMML) and the rarer MDS/MPN overlap syndromes share biological features, poor prognosis...
Double-hit alterations of TP53 identify ultra high-risk disease in previously treated, MYD88 mutated waldenstrom macroglobulinemia.
Abstract Background: BTK-inhibitors and chemotherapy (CT) with rituximab are widely used frontline treatments in Waldenström Macroglobulinem...
Transgenic expression of enhanced AsCas12a in mice enables In Vivo multiplex genetic editing and development of diverse novel models of myeloid neoplasms
Abstract A central challenge for the development of engineered models of myeloid malignancies is the genetic complexity of human disease, as...
Patients with multiple sclerosis above age 60 have neurological responses to autologous hematopoietic stem cell transplants similar to younger individuals: A single center experience
Abstract Background: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, characterized by inflammation, demyelin...
A Phase II, single-center, single-arm study evaluating the safety and efficacy of golidocitinib in the management of newly diagnosed PTCL (GOLDEN Study)
Abstract BackgroundFirst-line (1L) therapy for peripheral T-cell lymphoma (PTCL) is cyclophosphamide, doxorubicin, vincristine and prednison...
Use of red cell deformability measurements to assess the impact of pyruvate kinase activators on combined drug and transfusion therapies
Abstract Background Sickle cell disease (SCD) is characterized by poorly deformable red blood cells (RBC) that worsen wi...
Epigenetic reprogramming via EZH1/2 inhibition enhances T cell-mediated immunotherapies against multiple myeloma
Abstract Introduction: Although BCMA-targeted CAR-T therapies and CD3×BCMA bispecifics (e.g., teclistamab) have shown clinical promise, most...
Race-based disparities in hemorrhagic stroke mortality with underlying coagulopathies: A CDC-wonder analysis (1999–2020)
Abstract Background: Hemorrhagic stroke with coagulopathies carries a high risk of mortality and disability. Despite advances in care, dispa...
Novel CD117 T-cell engagers for targeted bone marrow HSPC depletion
Abstract Bone marrow transplantation (BMT), aimed at replacing a defective hematopoietic system with a healthy one, offers curative potentia...
Incidence of cytokine release syndrome (CRS), immune effector cell-associated neurotoxicity syndrome (ICANS), infections and cardiovascular events across different chimeric antigen receptor (CAR) T-cell therapy products in large B-cell lymphoma (DLBCL): A nationwide analysis
Abstract Introduction: CAR T-cell therapy is an important treatment option for patients with relapsed or refractory (R/R) DLBCL. Three CAR T...
Disease burden and treatment patterns in patients with previously treated primary immune thrombocytopenia (ITP): A retrospective study using administrative claims data in the United States
Abstract Introduction Primary immune thrombocytopenia (ITP) is a rare autoimmune bleeding disorder characterized by increased platelet destr...
The phosphorylation by aurkb regulates transcriptional functions of KLF1 during erythropoiesis
Abstract Erythroid Krüppel-like factor (EKLF/KLF1) is a master transcriptional regulator of erythropoiesis, and when KLF1 is mutated, it lea...
Inferior vena cava agenesis presenting as iliofemoral deep vein thrombosis in a 49-year-old male
Abstract Introduction Inferior vena cava (IVC) agenesis is a rare congenital anomaly, often asymptomatic until early adulthood, when it may...
A human IL-6–Expressing PDX model of multiple myeloma recapitulates clinical features and supports patient-derived tumor engraftment
Abstract Background: Multiple myeloma (MM) is a malignancy of plasma cells characterized by bone destruction, anemia, and renal failure. Alth...
A dynamic comprehensive geriatric assessment demonstrates improvement in patient fitness after induction and predicts survival and treatment tolerability among older adults with newly diagnosed acute myeloid leukemia
Abstract Introduction: A comprehensive geriatric assessment (CGA) is recommended in older adults (OAs, age>60 years) with acute myelo...
Burden of immune thrombocytopenia in hospitalized myeloid leukemia patients: Analysis from a national inpatient database
Abstract Background Chronic lymphocytic leukemia (CLL) and Acute lymphocytic leukemia are the most commonly known leukemias that cause immun...
Treatment initiation pattern, ramp-up measures and management of AML patients treated in real life in Italy with venetoclax+azacitidine - first interim analysis of the prospective vero study
Abstract Introduction The VERO study (NCT06058741)aims to collect real-world data on effectiveness and safety of the com...