Blood
Articles in this Issue
Neomorphic chromatin engagement and epigenetic reprogramming by the IKZF1 N159Y tandem duplication mutant in b-acute lymphoblastic leukemia
Abstract Introduction IKZF1 regulates hematopoietic cell development and gene expression through DNA-binding. IKZF1 mutants, such as the IK6...
Incidence of cardiac toxicities in patients with hematologic malignancies treated with zanubrutinib compared to control, including BTK inhibitor (Ibrutinib): A meta-analysis of randomized controlled trials
Abstract Background: Zanubrutinib is a highly selective, next-generation covalent Bruton's tyrosine kinase (BTK) inhibitor designed to maxim...
Choice of hypomethylating agent for newly diagnosed TP53-mutant Acute Myeloid Leukemia: A command registry study
Abstract Introduction:Owing to inherent chemoresistance and poor outcomes in TP53 mutant (m) acute myeloid leukemia (AML), treatment strateg...
A Phase I, open-label study of CTD402, a universal CD7-targeting CAR T-cell therapy, in patients with relapsed/refractory severe aplastic anemia
Abstract Background and Significance Severe Aplastic Anemia (SAA) is a bone marrow failure disorder mediated by abnormally activated T-lympho...
Pomalidomide downregulates FIZ1 to induce fetal hemoglobin in adult erythroid progenitors
Abstract Reactivation of fetal hemoglobin (HbF) expression has been a target for the treatment of hemoglobinopathies such as sickle cell dis...
Efficacy and safety of sorafenib combined with Standard Chemotherapy in adult patients with Myeloid sarcoma: A multi-center, cohort study
Abstract Background Currently, treatment for myeloid sarcoma (MS) primarily follows protocols of AML including standard chemotherapy and hem...
Secondary malignancies after hematopoietic cell transplantation for sickle cell disease: A single-center experience
Abstract Introduction: Sickle cell disease (SCD) is a severe inherited hemoglobinopathy associated with significant morbidity and mortality....
Single-cell DNA sequencing uncovers synergistic co-mutations in multiple myeloma
Abstract Background: Despite recent advancements in treatment for multiple myeloma (MM), most patients eventually relapse due to the emergen...
Impact of treatment with fostamatinib on coagulation profile of patients with immune thrombocytopenia
Abstract Background: Immune thrombocytopenia (ITP) is an acquired autoimmune disorder that is associated with an increased risk of venous an...
Hematopoietic cell-derived mitochondria transfer reduces morbidity and mortality in a mouse model of leigh syndrome
Abstract Introduction: Mitochondria transfer is a recently described phenomenon in which donor cells deliver mitochondria to acceptor cells....
An updated systematic review and meta-analysis of caplacizumab for immune thromboticthrombocytopenic purpura: Insights into efficacy and safety
Abstract Background: Immune thromboticthrombocytopenic purpura (iTTP) is a rare but life-threatening hematologic condition associated with th...
Impact of neutropenia on clinical outcomes in myelodysplastic syndrome patients hospitalized with sepsis: Insights from a national inpatient sample (2016–2022)
Abstract Background: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders often complicated by infect...
Outcomes of low-intensity AML therapy based on treatment facility
Abstract Background Historically, AML management required prolonged inpatient care, typically at academic centers. With...
Long-acting GM-CSF-based drug conjugate effectively targets leukemia stem cells in Acute Myeloid Leukemia with limited toxicity
Abstract Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy with poor prognosis and frequent relapse, largely driven b...
Disruption of NEAT1-transcriptional network identifies targetable non-genetic dependencies in multiple myeloma
Abstract Long non-coding RNAs (lncRNAs) represent an important layer of gene regulation and have emerged as significant contributors to mult...
Real-world outcomes of younger patients with chronic lymphocytic leukemia treated with first-line BTK inhibitor or BCL2 inhibitor therapy
Abstract Background Chronic lymphocytic leukemia (CLL) is the most prevalent leukemia, predominantly affecting older adu...
Understanding patient preferences for treatment of acute leukemia in the unites states: A discrete choice experiment
Abstract BACKGROUND: Acute leukemia is a cancer of the white blood cells that progresses rapidly and aggressively. For adult patients, failu...
Oral azacitidine maintenance improved survival for t-AML or AML-MR patients in first remission after CPX-351 and not eligible to HSCT
Abstract Background Oral AZA (Onureg, CC-486) is a maintenance therapy administered at the dose of 300 mg daily, 14 days of a 28-day cycle [1...
Impact of statin use on outcomes in chronic lymphocytic leukemia patients receiving ibrutinib therapy: A real-world study
Abstract Background: Ibrutinib, a Bruton tyrosine kinase inhibitor, has transformed the management of chronic lymphocytic leukemia (CLL), bu...
Management and outcomes in patients with cryptogenic stroke and weakly positive antiphospholipid antibodies
Abstract Introduction Younger patients with cryptogenic stroke typically undergo testing for antiphospholipid antibodies (aPL). Patients with...
Molecular association with elevated LDH levels in patients with AML
Abstract Prognosis in acute myeloid leukemia (AML) patients is influenced by various factors, most importantly, patient clinical status and...
Clinical characteristics and transplant outcomes in pediatric patients with transfusion-dependent alpha-thalassemia undergoing HSCT
Abstract Introduction：Hematopoietic stem cell transplantation (HSCT) remains the only curative treatment for transfusion-dependent alpha-th...
Critical role for MLL3-phd domains in HSC self-renewal and AML suppression
Abstract MLL3 and MLL4 are homologous histone methyltransferases that nucleate COMPASS (Complex of proteins associated with SET1) complexes....
Temporal trends in incidence and survival of Acute Myeloid Leukemia by age group: A SEER based analysis (2000–2022)
Abstract Acute myeloid leukemia (AML) is a heterogeneous and aggressive hematologic malignancy with a particularly poor prognosis in older a...
KRAS mutations in histiocytic neoplasms: Mutation spectrum and response to MEK inhibition
Abstract Introduction Histiocytic neoplasms (HN) are a rare, heterogeneous group of hematologic disorders derived from myeloid-dendritic cel...