Blood
Articles in this Issue
Unveiling prognostic subtypes in myelofibrosis through routine blood counts: A population-based analysis of the cytopenic and proliferative phenotypes in andalusia, Spain
Abstract Background Most published myelofibrosis (MF) data come from clinical trials or hospital registries, mainly from large centers, with...
Ravulizumab demonstrates real-world effectiveness in patients with paroxysmal nocturnal hemoglobinuria: A US chart review study
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder characterized by uncontrolled ter...
Autologous, allogeneic haemopoietic stem cell transplantation and CART cell therapy for tranformed Waldenström's macroglobulinemia to high grade non-Hodgkin lymphoma. real world outcomes report from the lymphoma working party of the european society for blood and marrow transplantation (LWP EBMT)
Abstract Introduction: High grade transformation of Waldenstrom's Macroglobulinemia (tWM) is a rare but serious complication and there is lim...
Eccdna-encoded LIPIN1 drives DGAT1-dependent lipid droplet biogenesis to promote Acute Myeloid Leukemia progression and chemoresistance
Abstract Introduction: Extrachromosomal circular DNA (eccDNA) has emerged as a critical player in cancer biology. Accumulating evidence indic...
A mouse model of aggressive ATL associated with oncogenic mutations and an HBZ-expressing hematopoietic environment
Abstract [Introduction] Adult T-cell leukemia/lymphoma (ATL) is a peripheral T-cell malignancy that develops decades after HTLV-1 infection....
Liver knock-out of nuclear inhibitor of protein phosphatase-1 in mice decreases hepatic iron
Abstract The liver plays a critical role in iron homeostasis and serves as the iron recycling and storage place. It also produces hepcidin,...
Acute myocardial infarction following allogeneic hematopoietic stem cell transplantation: Lessons learned from a national representative study
Abstract Introduction Acute myocardial infarction (MI) is a rare but life-threatening complication following allogeneic hematopoietic stem c...
Subcutaneous, every-four-week maintenance dosing of a novel protein S antibody is well-tolerated and substantially reduces bleeding rates: Results from A phase 1/2 multidose study of VGA039 in patients with von Willebrand disease
Abstract Introduction: Patients with von Willebrand Disease (VWD) experience frequent, prolonged bleeding of variable types and severity. Re...
Computational profiling of predicted neoantigen landscape reveals differential immunogenicity at AML diagnosis and relapse
Abstract Introduction Although AML carries a relatively low mutational burden and was once considered poorly immunogenic, immune escape has n...
Lymphoma are the most frequent secondary hematologic malignancies following solid tumors: A large cohort study from the german cancer registry nrw
Abstract Background: Cancer survivorship faces many challenges, including secondary malignancies. Several studies have examined neoplasms af...
Second Primary Malignancy in Multiple Myeloma: a retrospective monocentric analysis of Department of Hematology of the Oncologic Hospital from Cagliari
Abstract Background: Novel agents have changed the treatment landscape of multiple myeloma (MM). The improvement in treatment outcomes of MM...
Disruption of the gut microbiota promotes chronic inflammation in JAK2V617F-driven MPN: Evidence from mouse and human studies
Abstract Elevated levels of pro-inflammatory cytokines are linked to increased thrombotic risk and disease progression in myeloproliferative...
Early detection of emerging safety signals in GVHD prophylaxis agents using a 12-year faers “slope-watch” approach
Abstract Background: Over the past decade, the prevention of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell trans...
Outcomes with dasatinib in Philadelphia Chromosome–Positive acute lymphoblastic leukemia: A systematic review and meta-analysis
Abstract Introduction: Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) is a high-risk leukemia subtype with limited...
Advanced practice provider led programs improve patient access: The APP lymphoma diagnostic program
Abstract Purpose: Lymphoma consists of a heterogeneous group of cancers that range from indolent to aggressive, and differentiating malignan...
Racial disparities in survival trends in burkitt lymphoma in the CAR-T cell therapy era vs pre-CAR-T cell therapy era in the United States: A population-based study
Abstract Background: Burkitt lymphoma (BL) is an uncommon and aggressive B cell non-Hodgkin lymphoma (NHL) that develops...
Closing analysis of the patient and disease characteristics of the UK primary paediatric ITP registry
Abstract Introduction: Immune thrombocytopenia (ITP) is a rare autoimmune disorder characterised antibody-mediated platelet and megakaryocyt...
Long-term follow-up of the first in human post-transcriptional genetic silencing of BCL11A in sickle cell disease in a phase 1 pilot and feasibility trial
Abstract We conducted a first-in-human phase 1 dose-finding pilot and feasibility study testing the safety of gene therapy using a lentiviru...
Prognostic impact of cytogenetic abnormalities in aggressive T-cell lymphomas: Defining high-risk subgroups through conventional karyotyping.
Abstract Introduction Mature T-cell lymphomas, including aggressive nodal PTCL, advanced stage CTCL, and extranodal cytotoxic lymphomas, are...
Tet2 clonal hematopoiesis enhances thrombotic pathologies, increases platelet reactivity, and alters megakaryote function in the context of aging
Abstract Cardiovascular diseases (CVDs)—including heart attacks, strokes, and thrombotic events—account for over 80% of deaths in individual...
Description of neurocognition in adult sickle cell disease patients using the NIH toolbox
Abstract Background: Increasingly studied are the neurocognitive complications in adults with SCD. The most common presentation of such is a...
A clinical case study: the potential impact of maternal anti-Co4 antibody on Pregnancy Conceived by in vitro fertilization (IVF)
Abstract The Colton blood group system (CO, ISBT 015), is a blood group system characterized by antigens present on aquaporin-1 (AQP1), a mu...
Genomic insights and risk stratification in AML: Findings from a uniquely young national cohort in Qatar (AML-QC)
Abstract Background Acute myeloid leukemia (AML) is a heterogeneous stem cell malignancy marked by considerable genetic and clinical variabi...
Cytoskeletal rearrangements and SRC signalling defects controlled by PP1β drive impaired megakaryocyte maturation and platelet production
Abstract Platelet production is a highly regulated process involving coordinated signaling and cytoskeletal remodeling. While thrombopoietin...
CAR T cell-driven induction of iNOS in tumor associated macrophages promotes CAR T cell resistance in B cell lymphoma
Abstract Chimeric antigen receptor (CAR) T cell therapies have revolutionized B cell malignancy treatment, but subsets of patients with larg...