Blood
Articles in this Issue
Mismatching of unrelated donors beyond a single HLA-locus does not adversely impact outcomes at one year following transplantation: Results from the NMDP sponsored ACCESS study
Abstract Allogeneic hematopoietic cell transplantation (HCT) remains inaccessible to many patients, particularly those of non-European ances...
Cerebral hemodynamic response to chronic transfusion is associated with cerebral vasculopathy in sickle cell anemia
Abstract Background Diffuse correlation spectroscopy (DCS) is a novel, non-invasive optical technique that measures an i...
Health-related quality of life (HRQoL) in patients with relapsed/refractory follicular lymphoma treated with epcoritamab in combination with rituximab plus lenalidomide (E+R2): Primary results of the EPCORE FL-1 trial
Abstract Introduction: Relapsed/refractory follicular lymphoma (R/R FL) is an indolent disease characterized by multiple relapses, with some...
The addition of EBV and C3 complement risk factors formed a better angioimmunoblastic T-cell lymphoma prognostic scoring system
Abstract Background: Angioimmunoblastic T-cell lymphoma (AITL), a distinct subtype of peripheral T-cell lymphoma (PTCL), exhibits unique cli...
primary CD34+ derived mast cells provide an excellent platform to assess single agent and combination therapies for mastocytosis
Abstract Mast cells are multi-functional tissue-dwelling cells involved in various pathological conditions such as allergy, asthma, cardiova...
Transfusion burden during the initial induction Phase in Acute Myeloid Leukemia is tightly associated with treatment intensity
Abstract Introduction The continuously evolving therapeutic landscape of acute myeloid leukemia (AML) in the intensive and non-intensive set...
Regulation of ribosomal RNA synthesis in Acute Myeloid Leukemia
Abstract Hematopoiesis generates a complex hierarchy of cells with distinct functions, proliferation rates, and lifespans. A key determinant...
Wildtype NUP98 cooperates with NPM1c to drive oncogenic transcription
Abstract Nucleophosmin mutations are among the most common aberrations in acute myeloid leukemia (AML). We previously uncovered a novel pivo...
Unidirectional synergy between ferroptosis and apoptosis reveals a novel therapeutic strategy for refractory AML
Abstract Background: Apoptosis resistance drives treatment failure in relapsed/refractory (R/R) acute myeloid leukemia (AML). Targeting non-...
Total marrow and lymphoid irradiation (2000 cGy) together with cyclophosphamide and etoposide prior to allogeneic hematopoietic cell transplantation is an effective regimen for Relapsed/Refractory leukemia, with low non-relapse mortality
Abstract Background: Total marrow and lymphoid irradiation (TMLI) delivers augmented doses of radiation to the bone marrow (BM) and lymph no...
Bleed-versus-clot paradox under immune-checkpoint inhibition: A decade-long US faers analysis reveals divergent class-specific hemostatic phenotypes
Abstract Background: Immune-checkpoint inhibitors (ICIs) have transformed cancer therapy but can destabilize coagulation, leading to both th...
Immune exhaustion limits CD19 CAR-T efficacy in Richter's transformation
Abstract Background: Despite recent advancements in the treatment of chronic lymphocytic leukemia (CLL), Richter's transformation (RT) into...
Healthcare resource utilization and cost of molecular targeted versus non-targeted therapies in acute myeloid leukemia
Abstract Background Molecular targeted therapies (MTTs) have provided new treatment options for patients with Acute myeloid leukemia (AML) w...
Velora pioneer, Phase 1/2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of HMB-002 for prophylaxis in von Willebrand disease: A trial in progress
Abstract Background: Von Willebrand Disease (VWD), the most common inherited bleeding disorder, results from quantitative or qualitative def...
Spliceosome mutations in AML: Prevalence, clinical features, and treatment outcomes in a contemporary cohort
Abstract Background Spliceosomes are intranuclear proteins that splice pre-mRNA into mature mRNA. Somatic mutations in genes encoding spliceo...
The presence of SH2B3 mutations identifies a distinct subtype of myelodysplastic neoplasms
Abstract Background & aim: While SH2B3 gene mutations have been identified in myeloproliferative neoplasms, where they negatively regula...
Mutations landscape of relapsed refractory multiple myeloma patients prior to anti-BCMA treatment
Abstract Introduction: The approval of anti-BCMA therapies has significantly expanded the treatment arsenal and has prol...
“I feel like I'm being recognized as being a part of his treatment”: Caregiver perspectives of the serious illness care program for older patients with hematologic malignancies
Abstract Introduction Patients with hematologic malignancies (HMs) often have unpredictable illness trajectories and higher end-of-life heal...
Clinicopathologic features of myeloid neoplasms and pre-neoplasms with isolated ZRSR2 mutations
Abstract Introduction: The ZRSR2 gene, located at Xp22.2, encodes a protein component of the RNA spliceosome. Alterations in ZRSR2 have been...
Itacitinib in combination with post-transplant cyclophosphamide and tacrolimus (ICT) as GVHD prophylaxis for reduced intensity matched donor peripheral blood stem cell hematopoietic cell transplantation: Interim analysis
Abstract Post-transplant cyclophosphamide (PTCy) has emerged as a cornerstone of graft-versus-host disease (GvHD) prophylaxis in reduced int...
Efficacy and safety of zanubrutinib combination therapy and monotherapy maintenance in patients with follicular lymphoma: A retrospective single-center analysis
Abstract Background Zanubrutinib, a next-generation Bruton's tyrosine kinase inhibitor, has shown promise in the management of indolent B-ce...
High rates of hypertension, improved renal outcomes in complement-mediated thrombotic microangiopathy
Abstract Background: Our center previously reported a high lifetime prevalence of (HTN), chronic kidney disease (CKD), and major adverse car...
Targeting CSF1R to overcome myeloid cell suppression in CART therapy
Abstract Chimeric antigen receptor T (CART) cell therapy has shown unprecedented success in the treatment of hematological malignancies. How...
Allogeneic stem cell transplant for T-prolymphocytic leukemia: A single center analysis
Abstract Introduction: T-prolymphocytic leukemia (T-PLL) is a rare subtype of mature T-cell leukemia that is associated with poor outcomes,...
Use of bispecific antibody talquetamab before leukapheresis may lead to out-of-specification ciltacabtagene autoleucel manufacturing: A university of Arizona experience
Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapy has transformed the management of relapsed or refr...