Blood
Articles in this Issue
Clinical characteristics and prognostic factors in myeloid blast-Phase chronic myeloid leukemia
Abstract Background The advent of the tyrosine kinase inhibitor (TKI) era has resulted in long-term survival for patients with chronic-phase...
Evaluating the efficacy of brief neurocognitive assessments in adults and adolescents with sickle cell disease
Abstract Introduction: Sickle cell disease (SCD) is a common, life-threatening inherited hemoglobin disorder characterized by both acute and...
Multi‑omics analysis of Del20q reveals PHF20 haploinsufficiency and an HDAC2-centered epigenetic circuit in myeloid neoplasms
Abstract Deletion of chr. 20q (del20q) is detected in 5-8% of myeloid neoplasms and is one of the most frequent age-related CHIP events, ari...
Non-viral ultrasound-mediated delivery of an episomal FVIII expression vector enables durable FVIII protein production at therapeutic levels in non-human primates
Abstract Hemophilia A (HemA) is a monogenic bleeding disorder caused by mutations in the F8 gene, which encodes coagulation Factor VIII (FVI...
Changes in long-term bone health in patients receiving avapritinib for the treatment of indolent systemic mastocytosis in the pioneer study
Abstract Introduction: Indolent systemic mastocytosis (ISM) is a clonal mast cell disease driven by the KIT D816V mutation in ~95% of patien...
Global sex- and income-stratified disparities in mortality due to tobacco-associatedleukemia, 1990–2021
Abstract Abstract Introduction: Leukemia, a heterogeneous group of hematologic malignancies, has established association...
SLM124: A first-in-class anti-CD84 antibody-drug conjugate demonstrates potent anti-tumor activity and favorable tolerability in hematologic malignancy models
Abstract Background: The Signaling Lymphocytic Activation Molecule Family (SLAMF5), or CD84, is a novel target broadly expressed across a sp...
Clinics and clicks: Understanding hematology healthcare delivery utilization and preferences in the digital era
Abstract Background: The landscape of healthcare delivery in hematology has undergone significant transformations with the increasing adopti...
Selinexor-based regimens in triple-class exposed or refractory multiple myeloma: A real-world analysis of efficacy and safety in 18 patients
Abstract Background: Patients with triple-class exposed (TCE) or triple-class refractory (TCR) multiple myeloma (MM) have limited therapeuti...
Targeting bcaa metabolism induces synthetic lethality in DNMT3A-mutated acute myeloid leukemia
Abstract DNA methyltransferase 3A (DNMT3A)-mutant acute myeloid leukemia (AML) exhibits epigenetic dysregulation and chemoresistance, but th...
Impact of MYC alterations in de novo large B-cell lymphoma: An italian single center experience
Abstract Introduction: Large B-cell lymphoma (LBCL) with translocations involving MYC (MYC-T) and BCL2 (BCL2-T) +/- BCL6 (BCL6-T) (DHL-THL)...
Artificial intelligence–supported insight generation to inform medical education priorities in multiple myeloma
Abstract Introduction: The rapidly evolving treatment landscape in multiple myeloma (MM) presents a challenge for contin...
TET2 mutations drive cell-autonomous type I interferon production and selective advantage through TRIM4 silencing
Abstract TET2 mutations cause clonal expansion of hematopoietic stem and progenitor cells (HSPCs) and chimeric antigen receptor (CAR)-expres...
Clinical features of castleman disease: Single institution experience
Abstract Background: Castleman disease (CD) is an extremely rare lymphoproliferative disease presenting with abnormal lymph node enlargement...
Hematopoietic stem cell transplantation in 746 children with osteopetrosis: A study of the inborn errors working party of the EBMT
Abstract Introduction Osteopetrosis (OP) is a group of rare inherited conditions characterized by dysfunctional osteoclasts, leading to hypo...
HIF-1 and HIF-2 pathways in regulation of hepcidin
Abstract Hepcidin, the master regulator of iron metabolism, inhibits absorption and release of iron from macrophages through interaction wit...
Integrating bispecific antibodies into VA oncology care: A multidisciplinary protocol and education model from visn 20
Abstract Multiple myeloma (MM) is a disabling hematologic malignancy requiring continuous therapeutic innovation and timely intervention to...
Non-invasive Mantle Cell Lymphoma risk stratification by inference of tumor proliferation from cfDNA
Abstract Background: Variability in tumor proliferation is a key prognostic factor in Mantle Cell Lymphoma (MCL). However, its measurement b...
Real-world treatment patterns and clinical outcomes among patients with paroxysmal nocturnal hemoglobinuria treated with iptacopan in the United States
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening hematological disorder affecting ≈24 per 1,000,...
Therapeutic targeting of the recurrent mutant TP53R248Q neoantigen by T cell receptor-engineered T cells in human cancers
Abstract Background Malignant tumors with TP53 mutations exhibit poor therapeutic outcomes and high recurrence rates. T cell receptor (TCR)-...
Head-to-head longitudinal comparison of two mass spectrometry-based methods for monitoring monoclonal proteins in multiple myeloma: Analytical and clinical insights from the GEM-CESAR trial
Abstract Background: Mass spectrometry (MS) is increasingly used to detect monoclonal proteins (MPs) in patients with monoclonal gammopathie...
Optimizing Bcl11b timing enhances natural killer cell differentiation and cytotoxicity from human pluripotent stem cells for effective immunotherapy
Abstract Human hematopoietic stem cells (HSCs) derived from induced pluripotent stem cells (iPSCs) are revolutionizing regenerative medicine...
Socioeconomic, racial, and hospital-level disparities in inpatient mortality among patients with plasma cell dyscrasias: A 2016-2022 nationwide analysis from the national inpatient sample
Abstract Introduction: The discovery of new therapeutic options in plasma cell dyscrasias (PCDs) has advanced significantly over the last de...
Safety and outcomes of venetoclax initiation in patients with AML and hyperleukocytosis
Abstract Introduction: Venetoclax in combination with hypomethylating agents has improved outcomes in acute myeloid leuk...
Evaluation of treatment responses to methotrexate and cyclophosphamide among T-LGL patients with and without Y640F and D661Y STAT3 mutations – a retrospective observational study
Abstract Introduction T-cell large granular lymphocytic leukemia (T-LGL) is a rare chronic lymphoproliferative disorder characterized by a c...