Blood
Articles in this Issue
Early post-marketing safety signals of CRISPR-edited exagamglogene autotemcel (Casgevy) versus lentiviral betibeglogene autotemcel (Zynteglo): A faers disproportionality study, 2014–2025
Abstract Background: CRISPR-based genome editing entered clinical use with exagamglogene autotemcel (Casgevy) for severe...
Patients want more than FISH: Survey of 480 myeloma and precursor patients shows strong preference for blood-based whole genome sequencing
Abstract Background: The expansion of genomic testing in multiple myeloma (MM) has focused largely on targeted assays (e.g., FISH, NGS), whi...
A pilot study of nicotinamide riboside supplementation in allogeneic bone marrow transplantation
Abstract Allogeneic hematopoietic cell transplantation requires intensive chemotherapy conditioning followed by donor-derived hematopoietic...
Economic burden of relapse in patients with acute lymphoblastic leukemia: A retrospective claims-based analysis
Abstract Introduction:Acute lymphoblastic leukemia (ALL) imposes substantial disease burden and high healthcare resource utilization (HCRU)...
Disparities in autoimmune hemolytic Anemia–Related mortality in the u.S.–Mexico border region, 1999–2020: A CDC wonder study.
Abstract Background: Autoimmune hemolytic anemia (AIHA) is a rare but potentially life-threatening condition characterized by the premature...
The growing burden of high body mass index associated hematological cancer mortality in the United States of America (USA): A 30-year analysis (1990–2021)
Abstract Introduction High body mass index (BMI) is a well-established and modifiable risk factor that significantly con...
BACH2 regulates T cell lineage states to overcome dysfunction driven by tonic CAR signaling
Abstract Like T cell receptors (TCRs), chimeric antigen receptors (CARs) trigger potent intracellular signaling upon engagement with antigen...
Circulating tumor DNA analyses of molecular tumor burden are superior to PET-assessed responses in patients with advanced stage classic Hodgkin lymphoma treated on SWOG S1826
Abstract Introduction: Classic Hodgkin lymphomas (cHL) have genetic bases for enhanced PD-1 signaling and the highest reported response rate...
Optimizing adherence to oral CLL therapies in community oncology centers: Key findings from a quality improvement initiative
Abstract Background Oral therapies offer a convenient treatment option for patients with chronic lymphocytic leukemia (CLL), enabling at-hom...
Orelabrutinib combined with short-course bendamustine-rituximab (BR) for first-line treatment of chronic lymphocytic leukemia: A prospective multicenter study
Abstract Background While BTK inhibitors (BTKi) combined with 6 cycles of FCR achieve high rates of MRD negativity and prolonged treatment-f...
Genomics define neoplastic transformation in multiple myeloma precursor conditions
Abstract Background: Multiple myeloma (MM) is always preceded by monoclonal gammopathy of undetermined significance (MGUS) and smoldering mu...
Orelabrutinib, rituximab, and thiotepa (ORT) in combination with or without high-dose methotrexate in untreated primary central nervous system lymphoma
Abstract Introduction Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin's lymphoma, predominantly diffuse large...
Impact-CML: Indian multicentric data supporting safe pregnancy and molecular control in women with chronic myeloid leukemia
Abstract Introduction Data guiding management of tyrosine kinase inhibitors (TKI) during pregnancy in chronic myeloid leukemia (CML) are lim...
Interim Results of the CMML scrna-seq atlas: GMP skewing is independently associated with overall survival in CMML.
Abstract Background The expansion of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow is universally associated with advers...
Treatment of high-risk newly diagnosed multiple myeloma with minimal residual disease-guided therapy：daratumumab, carfilzomib, lenalidomide, and dexamethasone (DKRd)
Abstract Background MM is a highly heterogeneous malignant tumor, some patients derive limited benefit from current standard treatments, exh...
Statin use and the risk of Acute Myeloid Leukemia: A retrospective propensity-matched cohort study
Abstract Background: Statins, among the most widely prescribed medications worldwide, inhibit the mevalonate pathway and are well-establishe...
JMJD1C-mediated epigenetic control of HIT antibody production
Abstract Heparin-induced thrombocytopenia (HIT) is a common drug-induced immune disorder that occurs in a subset of heparin-treated patients...
Treatment with sirolimus for refractory/relapsed primary or secondary warm autoimmune hemolytic anemia/evans syndrome: A single centre prospective study
Abstract Background There are unmet needs for patients with warm antibody autoimmune haemolytic anaemia (wAIHA) and Evans syndrome (ES) who...
Insights in the management of older adults with mantle cell lymphoma amidst a changing therapeutic landscape: Lessons from a 25-year institutional experience
Abstract Introduction Treatment (tx) of older adults (OA) with mantle cell lymphoma (MCL) is evolving rapidly. Historically, chemoimmunother...
Clinical outcomes and predictors of mortality in patients with essential thrombocytosis and concurrent myocardial infarction: A nationwide analysis
Abstract Introduction: Essential thrombocytosis (ET) is a myeloproliferative neoplasm associated with an increased risk of both arterial thr...
Predictors of outcomes to allogeneic hematopoietic cell transplantation (allo-HCT) for TP53 mutant myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML) patients and impact of hypomethylating agent (HMA) maintenance therapy
Abstract Introduction TP53 mutant multi-hit MDS/AML patients have a median overall survival (OS) of 6-9 months. Despite continual improvemen...
Treatment intensity may alter the prognostic impact of baseline co-mutations in newly diagnosed FLT3-ITD AML treated with FLT3 inhibitor-based therapy
Abstract Introduction: FLT3 inhibitors (FLT3i) have improved outcomes in newly diagnosed (ND) FLT3-ITD mutated (mut) AML. A recent analysis o...
Impact of cohesin complex gene mutations on clinical outcomes in Acute Myeloid Leukemia
Abstract Background: The cohesin complex is a tetramer that plays a key role in chromatin interactions, DNA loop formations, and regulation...
Determinants of renal recovery and survival in patients with myeloma presenting with high circulating free light chains and renal impairement
Abstract Introduction: Patients with significantly elevated involved free light chains (iFLC) in myeloma have a high risk of renal impairment...
Clinical outcomes and novel therapeutic strategies in adult patients with MLL-rearranged acute lymphoblastic leukemia: A monocentric retrospective analysis
Abstract Introduction: Adults with MLL-rearranged b-cell acute lymphoblastic leukemia (MLL-r B-ALL) face dismal outcomes...