Blood
Articles in this Issue
Gene expression profiles of the nephron by urine mRNA: A liquid biopsy to investigate molecular changes in sickle cell nephropathy
Abstract Introduction: Sickle cell disease (SCD) is associated with damage to all of the segments of the kidney's nephron, including the glo...
Machine learning-based cost prediction in pediatric allogeneic bone marrow transplantation: Development and validation of an interactive clinical decision support tool
Abstract Background: Allogeneic bone marrow transplantation (BMT) costs exhibit substantial variability, yet robust prediction models for he...
DNMT3A, NPM1, and FLT3-ITD triple-mutated AML has a favorable prognosis in the era of FLT3 inhibitors
Abstract Background: FLT3-ITD mutations are common in AML, occur in a diverse co-mutation landscape, and are generally associated with a poo...
Etentamig plus pomalidomide-dexamethasone combination therapy in relapsed or refractory multiple myeloma: A phase 1b dose-escalation and safety expansion study
Abstract Introduction: Etentamig is a differentiated, 2nd generation, B-cell maturation antigen (BCMA) x CD3 bispecific T-cell engager compo...
Preclinical development of an optimized manufacturing, CRISPR-edited, fully non-viral 1XX-enhanced anti-BCMA CAR-T therapy for multiple myeloma
Abstract Background: B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor T cell (CAR-T) therapies have transformed treatment...
Modified-release formulation of decitabine and tetrahydrouridine combination not only increases exposure to decitabine but reduces exposure to unfavorable decitabine metabolites in healthy volunteers
Abstract Background: The modified-release fixed combination of decitabine and tetrahydrouridine (THU), NDec, is an inves...
A chronotherapeutic approach to VIP receptor antagonist (ANT308) in anti-tumor activity
Abstract Introduction: Heterogeneity in patient response to cancer treatment can be influenced by many factors, including the time-of-day tr...
Reduced overall survival in TP53-mutated ccus is driven by prior cytotoxic exposure and cytopenia rather than leukemic progression
Abstract Background: TP53-mutated (TP53mut) myeloid neoplasms (MN) are a biologically and clinically distinct subgroup of blood cancers asso...
Phase 1b study of cyclophosphamide, pomalidomide, dexamethasone, and daratumumab (CPD-DARA) in relapsed/refractory multiple myeloma: Safety and efficacy in a heavily pretreated population
Abstract Introduction Multiple myeloma (MM) is an incurable malignancy of clonal plasma cells. Incorporation of the monoclonal antibody darat...
Cytomegalovirus reactivation in teclistamab-treated multiple myeloma patients: Clinical outcomes and risk factors
Abstract Background: Teclistamab, a bispecific T-cell engager targeting BCMA, has demonstrated significant efficacy in relapsed/refractory m...
NPM1 and IDH1/2 mutations show limited prognostic impact in relapsed AML: Evidence from the avalon cohort
Abstract Background: NPM1 and IDH1/2 mutations are established prognostic biomarkers in newly diagnosed (ND) acute myeloid leukemia (AML) tr...
Effectiveness of remote patient monitoring in enabling outpatient step-up dosing for bispecifics at a large academic cancer center in the USA
Abstract Background Teclistamab (Tec) and talquetamab (Tal) are the two first approved T-cell engaging bispecific antibodies (BsAbs) for the...
Global patterns and inequities in environmental exposure-associated leukemia mortality by sex and socio-demographic index: A 32-year global analysis
Abstract Introduction: Leukemia, a malignant neoplasm of the hematopoietic system, remains a substantial contributor to...
From 1968 to 2050: Trends and forecasts of acute lymphoblastic leukemia mortality among older adults in United States
Abstract Introduction: Acute lymphoblastic leukemia (ALL) remains a rare but aggressive hematologic malignancy among older adults, with limi...
Treatment options, responses and outcome of 1220 classic Hodgkin lymphoma patients included in realysa, a prospective multicentric lysa cohort
Abstract Background: Classic Hodgkin lymphoma (cHL) therapies are progressing with different first-line chemotherapy regimens (CT), possibly...
TP53 exon 7 (c.742C>T; p. Arg248Trp) vaf suppression by novel oral allosteric NEK7 inhibitor in a patient with low-risk myelodysplastic syndrome in A phase 2 clinical trial
Abstract TP53 exon 7 (c.742C>T; p. Arg248Trp) VAF Suppression by Novel Oral Allosteric NEK7 Inhibitor in a Patient with Low-Risk Myel...
Germline variant database and visualization platform for BMF and hematologic malignancy predisposition syndromes: BMFgenes1.0
Abstract Background: In clinical practice, interpreting novel germline variants in bone marrow failure (BMF) and hematologic malignancy (HM)...
Myelofibrosis stem cell fitness requires microenvironmental cell interactions
Abstract Myelofibrosis (MF) originates at the level of the hematopoietic stem/progenitor cell (HSPC), and is associated with profound abnorm...
Mitoxantrone liposome, subcutaneous cytarabine and G-CSF (CMG) combined with venetoclax as first-line treatment in secondary Acute Myeloid Leukemia (sAML) or elderly AML patients: A multicenter, prospective, single-arm clinical trial with concurrent control
Abstract Objective: The prognosis of secondary acute myeloid leukemia (sAML) including AML with antecedent myelodysplastic syndromes (MDS) o...
Risk factors and mortality associated with venous thromboembolism in elderly patients with non-Hodgkin lymphoma
Abstract Risk factors and mortality associated with venous thromboembolism in elderly patients with non-Hodgkin lymphoma...
Mixed phenotype acute leukemia: Clinical characteristics and real-world outcomes
Abstract Introduction MPAL is a rare, heterogeneous leukemia defined by myeloid and lymphoid marker co-expression. The 2022 WHO classifies su...
RNA-sequencing improves risk stratification and guides treatment decision-making in acute lymphoblastic leukemia- a UK single centre experience
Abstract Background: Acute lymphoblastic leukemia (ALL) is genetically heterogeneous, necessitating precise molecular characterization for o...
Early identification of thrombosis risk in adult acute lymphoblastic leukemia
Abstract Background: Thrombosis is a known complication in patients with acute lymphoblastic leukemia (ALL) that potentially impacts morbidi...
Estimation of post-transfusion HbA level is relevant after RBC exchange in sickle cell adult patients
Abstract Background Transfusion (TF), or exchange transfusion (ExTF), is a major therapy for sickle cell disease (SCD) patients. However, th...
Chromosome genomic array testing (CGAT) improves diagnostic yield in patients with AML and MDS and has the potential for better risk stratefication - an NCI myelomatch and SWOG report
Abstract Introduction: Chromosome genomic array testing (CGAT) has been widely used in clinical genomic laboratories for...