Blood
Articles in this Issue
High tolerability and favorable early outcomes with full-dose lenalidomide in older adults with newly diagnosed multiple myeloma on triplet and quadruplet therapies
Abstract Introduction: The use of Lenalidomide (Len) with bortezomib and daratumumab (dara)-based triplet and quadruplet regimens have signi...
Kinetics of circulating multiple myeloma cells (CMMCs) in patients undergoing standard-of-care anti-BCMA chimeric antigen receptor T cell therapy for Relapsed/Refractory multiple myeloma
Abstract Chimeric antigen receptor (CAR) T cell therapies against B-cell Maturation Antigen (BCMA) are a highly effective therapy in patient...
Single-cell atlas of circulating immunity identifies shared specific DLBCL signatures predicting response to R-CHOP and CD19 CAR-t therapies
Abstract Background While the immunological heterogeneity of diffuse large B cell lymphoma (DLBCL) involves both the tum...
The role of RhoA in diffuse large B-cell lymphoma
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common type of aggressive lymphoma. DLBCL is divided into two major...
Racial, geographic, and gender disparities in ischemic heart disease mortality in patients with multiple myeloma: A nationwide analysis (1999–2023).
Abstract Background: Ischemic heart disease (IHD) is a leading causes of mortality in the United States. Patients with MM face elevated IHD...
Impact of innate immune memory on MDS progression by TET2-driven inflammation
Abstract Myelodysplastic syndrome (MDS) is a clonal, age-related bone marrow failure disorder. Mutations in the epigenetic regulator, TET2,...
Mutational patterns and prognosis in younger versus older AML patients with myelodysplasia-related gene mutations undergoing allogeneic hematopoietic stem cell transplantation
Abstract Introduction The international consensus classification (ICC) has identified nine specific mutations, including ASXL1, BCOR, EZH2,...
Graft vs host disease outcomes in early tacrolimus withdrawal following allogeneic hematopoietic stem cell transplant
Abstract Background: Post-transplant cyclophosphamide (PTCy), mycophenolate mofetil, and tacrolimus have become a standa...
Risk of returning to work and disability pension in multiple myeloma patients in central Norway
Abstract Multiple myeloma greatly impacts work ability and capacity in affected patients, compared to both the general population and to oth...
Cytokine profiling identifies an IL‑8/IL1RAP‑Pathway–Linked inflammatory phenotype in myeloproliferative neoplasms (MPN) associated with high symptom burden and poor outcomes
Abstract Background Chronic inflammation, characterized by elevated proinflammatory cytokines within the bone marrow (BM...
The need for re-induction based on D14-residual acute myeloid leukemia in patients achieving complete remission predicts higher relapse rate and inferior post-remission survival
Abstract Background: The primary goal of induction therapy in acute myeloid leukemia (AML) is to induce complete remission with (CR) or with...
Long term follow up of the response adapted FOLL12 trial for patients with advanced stage follicular lymphoma: A study by the fondazione italiana linfomi (FIL).
Abstract Background. The FOLL12 study demonstrated that in High tumor burden patients with Follicular lymphoma (FL) treated with immunochemo...
The sinister course of hemophagocytic lymphohistiocytosis
Abstract Hemophagocytic lymphohistiocytosis (HLH) is a rare and life threatening disease that causes systemic hyperinflammation, which can l...
Update AML: Updated disease monitoring and treatment to enhance outcomes for pediatric AML (NCT07059975)
Abstract Background and significance: Outcomes for children with acute myeloid leukemia (AML) have not improved in decades, despite three co...
FGF11–HIF-1α glycolytic epigenetic axis drives AML progression and chemoresistance via metabolic reprogramming
Abstract BackgroundAcute myeloid leukemia (AML) remains a lethal hematologic malignancy characterized by clonal expansion of immature myeloi...
Keeping it renal: Results of applying guideline-based management in sickle cell nephropathy
Abstract Introduction Current guidelines for the treatment of sickle cell nephropathy (SCN) endorse initiating angiotensin-converting enzyme...
COVID-19 IgG antibodies drive endothelial cell activation and dysfunction
Abstract The effect of COV-19 infection or post-acute sequelae of SARS-CoV-2 (PASC) increases risk of thrombotic events. The mechanism under...
Prognostic factors and survival outcomes of urgent inpatient chemotherapy for relapsed/refractory lymphoma in the modern era
Abstract Introduction: Patients (pts) with relapsed/refractory (RR) lymphoma frequently require urgent inpatient (inpt) admission for sympto...
Allogeneic hematopoietic cell transplantation risk stratification and eligibility using race-neutral versus race-specific pulmonary equations
Abstract Background: Pulmonary function tests, forced expiratory volume in 1 s (FEV₁) and diffusing capacity for carbon monoxide (DLCO), are...
A single-cell atlas of diagnostic bone marrow to uncover the origins of CML relapse following therapy cessation
Abstract Introduction Treatment-free remission (TFR) remains unpredictable in chronic myeloid leukemia (CML) management, with half of patien...
HLA and non-HLA factors in haploidentical donor selection: Insights from a brazilian single-center study
Abstract Introduction: Haploidentical bone marrow transplantation has emerged as the predominant form of allogeneic tran...
Development of the sickle cell outcome grading system (SCOGS), a novel classification system for sickle cell disease severity
Abstract Background Sickle cell disease (SCD) is a chronic, multisystem condition. This disorder causes red blood cells to sickle, resulting...
FK506 improves B cell reconstitution after allo-HSCT compared to csa: A real-world study
Abstract Background Immune reconstitution is closely associated with various transplant-related complications following allogeneic hematopoi...
Iguratimod plus low-dose rituximab as second-line treatment in adults with primary immune thrombocytopenia: A multicenter, open-label, randomized, controlled, Phase 2 trial
Abstract Introduction The optimal treatment for corticosteroid-resistant or relapsed immune thrombocytopenia (ITP) remains uncertain. Igurat...
A flk-independent pathway of megakaryopoiesis is differentially responsive to stress and can produce high proportions of functionally distinct platelets
Abstract Platelets and megakaryocytes (Mks) are increasingly recognized as diverse and dynamic cells that serve as critical components of th...