Blood
Articles in this Issue
Analysis of no bolus versus bolus unfractionated heparin nomograms in the management of pulmonary embolism: Insights from a real-world cohort
Abstract Background: Unfractionated heparin (UFH) is a cornerstone of acute pulmonary embolism (PE) management. A weight-based UFH nomogram,...
Prognostic significance of cell-of-origin, gene expression profiles, and frontline therapy in predicting secondary CNS lymphoma in newly diagnosed diffuse large B-cell lymphoma
Abstract Background Secondary central nervous system lymphoma (SCNSL) is a rare but significant complication, affecting...
Trial in progress: nutrition and exercise to optimize muscle and adiposity in adolescents and young adults with B-cell acute lymphocytic leukemia: The neoma ALL trial
Abstract Background and Significance: In 2021-2023, 40% of adults in the United States were obese (Emmerich, NCHS Data B...
Decoding acquired platelet dysfunction with eosinophilia: Clinical triad and flow cytometric signatures
Abstract Background Acquired Platelet Dysfunction with Eosinophilia (APDE) is a rare, under-recognized bleeding disorder...
Cardiovascular adverse events associated with bispecific antibodies in Relapsed/Refractory hematologic malignancies: A comprehensive systematic review and meta-analysis
Abstract Introduction: Bispecific antibodies (BsAbs), targeting two distinct antigens, offer promising treatment for relapsed/refractory hem...
Transcriptomic characterization of platelets in immune thrombocytopenia indicates sustained activation and mitochondrial dysfunction
Abstract Background Immune Thrombocytopenia (ITP) is a rare hematologic autoimmune disease marked by platelet (PLT) destruction and impaired...
The rearrangement partner and the presence of MYC mutations determines outcome of patients with MYC and BCL6 rearrangements
Abstract Background: MYC and BCL6 rearrangements (r) in high-grade B-cell lymphoma (HGBL) are generally associated with aggressive disease a...
The impact of duffy-null phenotype on neutrophil counts in patients with HbSC/ HbSβ+-thalassemia treated with hydroxyurea
Abstract Introduction: The Duffy-null phenotype is characterized by the lack of Duffy antigen expression on red cells and is associated with...
ST2 promotes leukemia transformation by reshaping the immune landscape in Acute Myeloid Leukemia
Abstract Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a 5-year survival rate of 30%, largely due to treatment...
A Phase 2 study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of sutacimig for prophylaxis in glanzmann thrombasthenia: A trial in progress
Abstract Background: Glanzmann thrombasthenia (GT) is a severe genetic bleeding disorder characterized by impaired platelet aggregation prev...
Deciphering clonal progression in MDS via longitudinal sequencing
Abstract Introduction Next-generation sequencing (NGS) has redefined the molecular taxonomy of myelodysplastic syndromes...
A Phase II multicenter study of minimal residual disease-guided, time-limited acalabrutinib + obinutuzumab for the initial treatment of chronic lymphocytic leukemia
Abstract Background: Advantages of covalent Bruton Tyrosine Kinase inhibitor (cBTKi) treatment (tx), as compared to BCL2 inhibitor (BCL2i) c...
A Phase 1b/ 2a study of budoprutug in patients with immune thrombocytopenia (ITP)
Abstract Background and Significance: Immune thrombocytopenia (ITP) is a rare disorder caused by accelerated, premature platelet destruction...
HLA alleles associated with inhibitor development in severe hemophilia A: Analysis of the “My life, our Future” hemophilia A cohort
Abstract An earlier analysis of data from the “My Life, Our Future” (MLOF) Research Repository (Ahmed and Pratt, 2023, PMID 36696179) indica...
A single-arm, open-label, multi-center, phase 1b/2 Study to evaluate the safety, efficacy, and cellular pharmacokinetic profile of CTD402 in participants with relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) and lymphoblastic lymphoma (T-LBL) (TENACITY-01)
Abstract Background and significance Relapsed/Refractory (R/R) T-ALL/LBL remains a significant therapeutic challenge due to lack of effectiv...
Cumulative cardiac risk strongly predicts in-hospital mortality and cost burden in patients hospitalized with chronic lymphocytic leukemia: A national inpatient analysis, 2020–2022
Abstract Background: Chronic lymphocytic leukemia (CLL) primarily affects older adults who often have preexisting cardiovascular comorbiditi...
Clinical outcomes in patients with multiple myeloma and antidepressant use: A retrospective cohort study
Abstract Background Clinical depression is associated with immune dysregulation and reduced activity of natural killer c...
Fatigue, hemoglobin, and inflammatory markers in warm autoimmune hemolytic anemia: Analysis from a phase 2b trial of rilzabrutinib (LUMINA2)
Abstract Background: Warm autoimmune hemolytic anemia (wAIHA) is characterized by complex immune dysregulation along with red blood cell des...
Characterization of sickle cell disease-associated organ dysfunction in aged Townes HbSS mice and effect of IMA001
Abstract Introduction: Sickle cell disease (SCD) is a hemolytic anemia caused by a mutation in the β-globin gene. Recurrent vaso-occlusive c...
Evolutionarily divergent notch regulation underpins the initiation of human T-cell development
Abstract Hematopoietic stem and progenitor cells (HSPCs) differentiate into diverse blood cell lineages through intricate genetic and epigen...
Allogeneic hematopoietic stem cell transplantation outcomes in pediatric acute lymphoblastic leukemia: A multicenter analysis from the cccg-ALL-2015 protocol
Abstract Background Acute lymphoblastic leukemia (ALL) represents the most prevalent pediatric malignancy. The Chinese C...
The efficacy of hypoxia-inducible factor prolyl hydroxylase inhibitor AND017 in NUP98-HOXD13transgenic mouse
Abstract Introduction Most of patients with myelodysplastic syndromes/neoplasms (MDS) exhibit variable degrees of anemia at diagnosis, primar...
Hibiscus 2 (Trial-in-Progress): A global, Phase 3, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of etavopivat in adolescents and adults with sickle cell disease
Abstract Background and Significance: Pyruvate kinase red blood cell (RBC) isozyme (PKR) is a key enzyme in glycolysis....
Facility-level disparities in outcomes of subcutaneous panniculitis-like T-cell lymphoma: A national cancer database analysis
Abstract Background Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an exceptionally rare malignancy, representing less than 1% of...
Comparison of hemosil and innovance antithrombin assays using Hemophilia A plasma and antithrombin lowering (to mimic fitusiran)
Abstract Introduction: There are several assays for measuring antithrombin (AT) activity that each use different reagents, targeting human o...