Blood
Articles in this Issue
Molecular determinants of therapeutic response to nivolumab in Relapsed/Refractory PTCL: An integrated multiomic study of A phase II investigator-initiated trial
Abstract Background: Peripheral T-cell lymphomas (PTCL) display heterogeneous responses to immune checkpoint inhibitors, including rare dura...
Genomic clustering informs risk-adapted conditioning regimens in AML with pre-transplant deep remission: Augmented stratification beyond ELN-2022 criteria
Abstract Background: The composition of conditioning regimens are critical determinants of post-transplant outcomes. However, there remains...
Mortality trends in patients with co-occurring chronic kidney disease and venous thromboembolism in the United States: A 25-year CDC wonder analysis (1999–2023)
Abstract Introduction: Chronic kidney disease (CKD) patients face elevated venous thromboembolism (VTE) risk due to neph...
Musculoskeletal ultrasound evaluation of joint health status and bleeding phenotype in severe and non-severe hemophilia (A and B)
Abstract Introduction: People with hemophilia (PwH) A and B are known to have variable bleeding phenotypes, may have joint bleeding that is...
Allogeneic dual-target CD19/BCMA CAR T-cell therapy (QT-019B) for refractory autoimmune hemolytic anemia
Abstract Background Refractory autoimmune hemolytic anemia (rAIHA) is characterized by severe, life-threatening hemolysis, and conventional...
Regional, and hospital-level disparities in mortality and ICU-level care among hospitalized peripheral T-cell lymphoma patients: Insights from the 2022 national inpatient sample
Abstract Background Peripheral T-cell lymphomas (PTCL) are a rare and aggressive subtype of non-Hodgkin lymphoma with poor overall survival...
Clinical disparities in enteropathy-associated T-cell lymphoma: A national cancer database study of 736 patients treated at academic and community cancer centers
Abstract I) Background Enteropathy-associated T-cell lymphoma (EATL) represents 3% of peripheral T-cell lymphomas. It co...
Clinical parameters and outcomes associated with genetic alterations in patients diagnosed with complement-mediated hemolytic uremic syndrome (CM-HUS): A single center experience
Abstract Background Complement-mediated HUS (CM-HUS) is a rare thrombotic microangiopathy (TMA) caused by congenital or acquired dysregulatio...
Outcomes of haploidentical hematopoietic stem cell transplantation in low- and middle-income countries: A systematic review and meta-analysis.
Abstract Introduction: Haploidentical hematopoietic cell transplantation (haplo-HCT) has emerged as a critical alternati...
Study on the efficacy and safety of HDAC inhibitor combined with venetoclax and azacitidine in the treatment of adult T-ALL
Abstract Background Acute T-ALL leukemia (T-ALL) is prone to primary drug resistance, induction failure, central infiltration, early recurre...
Proof-of-concept study of the CD39-blocking antibody JS019 in eosinophilic-associated disorders
Abstract Background CD39, an ectonucleotidase that hydrolyzes extracellular ATP to AMP, drives immunosuppressive adenosine accumulation and...
IMV101, a novel CD19-targeted In Vivo CAR T therapy exhibits potent efficacy and tolerable safety profiles in preclinical models
Abstract Background: Autologous CD19 CAR-T cell therapy has shown remarkable efficacy in B-cell hematologic malignancies, yet its widespread...
Decitabine enhances the cytotoxic effect of ruxolitinib in myeloproliferative neoplasms by targeting SR splicing factors
Abstract Introduction:The Breakpoint Cluster Region–Abelson (BCR-ABL) negative myeloproliferative neoplasms (MPNs) are a group of chronic he...
Dual roles of proton pump inhibitors in estrogen-induced venous thromboembolism
Abstract Venous thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism, is the third leading cause of cardiovascular m...
Resolvins modulate haematopoietic stem and progenitor cell dysfunction and neutrophil activation in sickle cell disease
Abstract Chronic inflammation is characteristic of sickle cell disease (SCD), and the resulting neutrophil activation plays a significant ro...
Chronic myelomonocytic leukemia: Clinical outcomes from clinical trials submitted to the FDA over the past 25 years
Abstract Introduction: Chronic myelomonocytic Leukemia (CMML) is a rare hematological malignancy with features of both m...
Sequential monitoring using NGS allows detection of ABL1 KD mutations in patients with chronic Phase CML: Results from the prospective calls trial
Abstract Background BCR :ABL1 kinase domain (KD) mutations are...
Shift toward more naïve phenotype of the T cell compartment in patients with aggressive B cell non-Hodgkin lymphoma undergoing high-dose methotrexate therapy
Abstract Introduction: Immunotherapies such as bispecific antibodies (BsAbs) and chimeric antigen receptor T cell therap...
Autoimmunity against POLR3A and cytopenias in aplastic anemia and other bone marrow failure syndromes
Abstract Idiopathic aplastic anemia (IAA) is mediated by cytotoxic T-cells directed toward unrecognized antigen(s) on hematopoietic stem and...
Improved long-term tolerability and efficacy of asciminib-based combination therapies in newly diagnosed CML patients - the fascination trial.
Abstract Introduction: “The Frontline asciminib in combination” - FASCINATION study (NCT03906292) is a multicenter, prospective, open-label,...
Evolution of joint health and physical activity in people with hemophilia A without factor VIII inhibitors switching to emicizumab prophylaxis: A second interim analysis of the BEYOND ABR study
Abstract Background: Advances in hemophilia A (HA) treatment have led to lower bleeding rates (Srivastava et al. Haemophilia 2020), shifting...
Uncovering molecular trajectories in follicular lymphoma using hidden markov models of ctdna dynamics
Abstract Circulating tumor DNA (ctDNA) is a valuable prognostic biomarker in follicular lymphoma (FL) frontline treatment, providing a minim...
GMP-compliant generation, expansion, and a preliminary safety evaluation of CMV-specific t cells using a closed system for post-transplant viral control
Abstract Despite advances in transplantation, recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain at high ri...
Comparative analysis of severe infection risk and survival outcomes in DLBCL patients treated with CAR T-cell therapy versus standard chemoimmunotherapy: Insights from real-world data
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) treatments, including standard chemoimmunotherapy (R-CHOP/R-EPOCH) and CAR T-cell...
This is hitting the heparin sweet spot: Here is a retrospective analysis of investigating and optimizing aPTT monitoring for safety and efficacy during intravenous heparin infusion
Abstract Introduction Unfractionated heparin (UFH) remains a cornerstone in the treatment of thromboembolic conditions such as deep vein thr...