Blood
Articles in this Issue
Phosphorylation-induced structural remodeling of band 3 as a driver of metabolic dysfunction in sickle cell disease
Abstract Red blood cells (RBCs), devoid of nuclei and organelles, rely on post-translational modifications and dynamic protein–protein inter...
T cell fitness and tumor specificity predict immunotherapy response in multiple myeloma
Abstract T cells are increasingly recognized as central effectors in the therapeutic response across a wide spectrum of treatments for multi...
VIP pathway inhibition alters microbial metabolism to balance graft-versus-leukemia and gvhd
Abstract Introduction: Emerging evidence highlights the gut microbiome as a critical player in gastrointestinal acute graft-versus-host dise...
Efficacy of acute normovolemic hemodilution in adult cardiac surgery in reducing the need for allogenic red cell transfusion: A systematic review and updated meta-analysis of randomized controlled trials.
Abstract Introduction: Allogeneic red blood cell transfusions during cardiac surgery increase risks of immunologic reactions, infections, an...
Phase 1 study of revumenib in combination with intensive chemotherapy (IC) in patients (Pts) with newly diagnosed (ND) Acute Myeloid Leukemia (AML) harboring genetic alterations in KMT2A, NPM1, or NUP98: SNDX-5613-0708
Abstract Introduction: Acute leukemias (AL) harboring a KMT2A or NUP98 rearrangement (KMT2Ar or NUP98r) confer unfavorable prognosis, and whi...
A novel prognostic model for predicting mortality in adults with sickle cell disease and severe sinusoidal obstruction syndrome
Abstract Background: Liver involvement in sickle cell disease (SCD) is often underdiagnosed, with hepatic complications...
Momelotinib-mediated transcriptional reprogramming induces synthetic lethal interaction with calcineurin-NFAT signaling
Abstract Despite notable advances in the development of targeted therapies for acute myeloid leukemia (AML), the emergence of treatment resi...
Novel approaches to identify cellular vulnerabilities in TET2-dependent MDS
Abstract MDS and related disorders manifest a tremendous diversity of molecular patterns originating from the founder lesions and depending...
A prognostic model integrating disease‑ and patient‑oriented factors identifies poor‑outcome patients with low‑risk MDS: A multicenter real‑world cohort study (KOTOSG)
Abstract Background Low-risk myelodysplastic syndromes (LR-MDS) are generally associated with a lower risk of progressing to leukemia and te...
Real-world analysis of ravulizumab safety and effectiveness in advanced age patients with paroxysmal nocturnal hemoglobinuria: Insights from the international PNH registry
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare blood disorder characterized by uncontrolled terminal complement ac...
Inhibitor of DNA binding 2 (ID2) is epigenetically regulated during lymphomagenesis and constitutes a novel therapeutic target in mature T-cell lymphoma
Abstract Mature T-cell lymphomas (TCL) are a heterogeneous group of non-Hodgkin lymphomas arising from the malignant transformation of post-...
SOUNDTRACK-F1: A phase 3, randomized, open-label study of surovatamig (AZD0486) plus rituximab versus chemotherapy plus rituximab in patients with previously untreated follicular lymphoma
Abstract Background and Significance: Follicular lymphoma (FL) is the most common indolent lymphoma and advanced-stage disease is considered...
Machine learning ensemble models for genetic-based classification of myeloproliferative and myelodysplastic/myeloproliferative neoplasms: Comparing a multinomial vs binomial approach
Abstract Background Myeloid malignancies such as myeloproliferative neoplasms (MPNs) and myelodysplastic/myeloproliferative neoplasms (MDS/M...
Significance of CD229 expression assessment for detection of minimal residual disease in patients with multiple myeloma.
Abstract Introduction Multiparameter flow cytometry (MFC) is one of the most reliable methods for monitoring minimal res...
A case series of pediatric patients with congenital thrombotic thrombocytopenia purpura (cTTP) treated with recombinant ADAMTS13
Abstract Background: Congenital thrombotic thrombocytopenic purpura (cTTP), also known as Upshaw-Schulman Syndrome, is an ultra-rare thrombot...
Second autologous transplantation remains a valid consolidation option in patients with relapsed multiple myeloma: A report from the Latin American bone marrow transplantation group
Abstract INTRODUCTION With the advent of novel therapeutic agents, the management of relapsed multiple myeloma (MM) has shifted markedly, an...
Real-world study on thrombopoietin receptor agonists combined with rituximab in the treatment of Relapsed/Refractory primary immune thrombocytopenia
Abstract Background Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder, but the management of relapsed/refractory cases remain...
Detection of KMT2A fusion transcripts after induction chemotherapy is strongly predictive of outcome in KMT2A rearranged AML: Results of an international collaborative study
Abstract KMT2A rearrangements (KMT2Ar) occur in ~5% of adult AML, making adequately powered studies of prognostic factors challenging. We an...
CD19 antigen: From tumor target to safety switch able to improve the safety profile of CAR T cell therapy
Abstract Background Chimeric antigen receptor (CAR) T cell therapy is an innovative immunotherapeutic approach that has...
MGA loss promotes mitochondrial structure changes and redox adaptation in richter's transformation
Abstract Richter's transformation, a highly aggressive and therapy-refractory progression of chronic lymphocytic leukemia (CLL), is characte...
Use of G-CSF in AML patients with febrile neutropenia: Friend or foe?
Abstract Background Febrile neutropenia (FN) is a common and potentially life-threatening complication in patients with acute myeloid leukemi...
Regulatory long noncoding RNA of T cells (ReLoT/LINC00402) impairs Rorγt+ allogeneic T cells
Abstract Long noncoding RNAs (lncRNA) are versatile cell- and context-specific regulators of immune cell responses. As such, they may be ide...
Outcomes of elderly (≥ 70) Acute Myeloid Leukemia (AML) patients receiving continued hypomethylating agent/venetoclax (HMA/VEN) versus allogeneic hematopoietic cell transplantation (HCT)
Abstract Introduction: HMA/VEN has transformed therapy for elderly patients with AML by improving complete remission (CR) rates, survival, a...
Quality of life and functional improvements with efanesoctocog alfa in patients with moderate-to-severe Hemophilia A: A real-world survey
Abstract Background: Hemophilia A (HA) is a rare X-linked bleeding disorder characterized by deficiency or dysfunction of clotting factor VI...
Defining evolutionary trajectories in myelodysplastic syndromes and integrating them into prognostic models to improve risk stratification: The progevo machine learning approach
Abstract Background Myelodysplastic Syndromes (MDS) are clonal hematopoietic stem cell disorders that evolve following a multi-step process....