Blood
Articles in this Issue
Chemotherapy-free treatment for children and adolescents with newly diagnosed acute promyelocytic leukemia (APL): Results of the prospective ICC-APL-02 study.
Abstract Introduction: Treatment of acute promyelocytic leukemia (APL) has been revolutionized over the past two decades by the introduction...
Healthcare resource utilization in people with hemophilia treated within vs. outside u.S. hemophilia treatment center network clinics: An interim analysis of the CHESS US study
Abstract Introduction People with hemophilia (PwH) in the United States (US) may receive comprehensive care through the Hemophilia Treatment...
The JAK1/2 inhibitor baricitinib revealed unique immune biomarkers in multirefractory immune thrombocytopenia patients
Abstract Introduction Multirefractory immune thrombocytopenia (ITP), defined by resistance to both corticosteroids and t...
SAMHD1 dependence of cgas-sting-associated anti-tumor immune responses in classical Hodgkin lymphoma
Abstract Background: The tumor microenvironment (TME) plays a pivotal role in the pathogenesis of classical Hodgkin lymphoma (cHL) because o...
Clinical and technological validation of locally-installed, privacy-compliant, and hematology-tailored ambient AI platform for clinical report transcription assistance and clinical trial patient management
Abstract Background Effective communication between clinicians and patients is vital in hematology for personalized treatment. However, trad...
Preliminary results from RIVER-81, a phase 2 study of romaciclib (RVU120) + venetoclax in patients with acute myeloid leukemia failing first-line venetoclax + hypomethylating agent (HMA)
Abstract Background: First-line venetoclax (VEN) in combination with hypomethylating agents (HMA) is the standard of car...
Enhanced clot formation and altered platelet subpopulations in mesothelioma characterized by a high-dimensional analytical platform
Abstract Background: Mesothelioma is a rare and aggressive lung cancer primarily caused by asbestos exposure. Thrombotic complications are c...
Eltrombopag plus G-CSF for peripheral blood stem cell mobilization: Final analysis of a single arm, Phase 2 trial
Abstract Introduction Autologous hematopoietic stem cell transplantation (auto-HSCT) is the standard treatment for relapsed/refractory lymph...
Patterns of patient referral for CAR-T cell therapy: Increasing access and changing utilization trends at a german tertiary care hospital from 2018 to 2024
Abstract CAR-T-cell-therapies (CARTs) have transformed the therapeutic landscape of B- and plasma cell malignancies. However, misconceptions...
Tfr2-mediated erythropoiesis expansion controls systemic glucose homeostasis by modulating erythroid metabolic demand
Abstract Introduction: Erythropoiesis is a highly energy-demanding and tightly regulated process. It involves cell proliferation, massive he...
Pooled analysis of early-Phase trials highlights robust activity of CD3-CD20 T-cell engagers in follicular lymphoma
Abstract Background: Follicular lymphoma (FL) is the most common indolent non-Hodgkin lymphoma. It's characterized by slow disease course bu...
Machine learning-based immunoinflammatory phenotypes predict survival in Latin American patients with diffuse large B-cell lymphoma: A multicenter cohort study of grupo de estudio latinoamericano de linfoproliferativos (GELL)
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma globally. In Latin America (LATAM), lim...
Racial disparities in inpatient outcomes and resource utilization in multiple myeloma: An NIS-based analysis (2016–2022)
Abstract Background: Multiple myeloma (MM) disproportionately affects racial and ethnic minority populations, with growing evidence indicati...
National trends and disparities in primary (essential) hypertension and pulmonary embolism-related mortality in the United States from 1999-2023: A CDC wonder database analysis abstract
Abstract Background: Chronic elevation of blood pressure, also known as Primary (essential) hypertension, is one of the...
ZBTB7A modulates response to BCL-2 inhibition by venetoclax in acute myeloid leukemia (AML)
Abstract Venetoclax, a selective BCL-2 inhibitor, in combination with azacytidine has become a standard-of-care treatment for older, and/or...
Preliminary experience from the ODYSSEY trial: Efficacy and safety of momelotinib in combination with luspatercept in patients with transfusion-dependent myelofibrosis
Abstract Introduction: The management of patients with transfusion-dependent (TD) anemia represents an area of high medical need in myelofibr...
FLT3/ITD-driven noncanonical STAT1 S727 phosphorylation upregulates CD276, mediating CD8positive- T cell exhaustion and immune evasion in AML
Abstract FMS-like tyrosine kinase 3 internal tandem duplications (FLT3/ITD) mutation promotes leukemogenesis and confers poor prognosis in a...
Management and outcomes of acute coronary syndromes in patients with immune thrombocytopenia: A single-center real-world study
Abstract Introduction Immune thrombocytopenia (ITP) is an autoimmune disorder causing low platelet counts and bleeding tendencies; however,...
Single center evaluation of TCRαβ+ T cell depletion using CliniMACS® plus platform: Optimizing cell selection for hematopoietic stem cell transplantation
Abstract Introduction TCRαβ+ T cell-depletion is a promising ex vivo graft engineering technique that effectively reduces the risk of graft-...
Precision targeting of immune-mediated thrombotic thrombocytopenic purpura (iTTP) with chimeric auto-antigen receptor (CAAR) T cells
Abstract Introduction: Immune Thrombotic Thrombocytopenic Purpura (iTTP) is a life-threatening thrombotic microangiopathy characterized by t...
Age and race drive adult T-cell leukemia/lymphoma incidence in the United States, not income or urbanicity: 2000-2022 SEER analysis of 699 cases
Abstract Background Adult T-cell leukemia/lymphoma (ATLL) is rare in the United States but clusters in specific racial a...
High cMPL expression identifies adult human long-term hematopoietic stem cells with superior multilineage and clonally balanced reconstitution potential
Abstract Thrombopoietin (TPO) and its receptor cMPL are key regulators of long-term hematopoietic stem cell (LT-HSC) maintenance. Clinical r...
Updated results from the Phase 1b/2 study of MK-1045, a novel CD19xCD3 T-cell engager, in adult participants with relapsed or refractory B-cell acute lymphoblastic leukemia
Abstract Introduction: MK-1045 (CN201) is a humanized bispecific IgG4 CD19xCD3 T-cell engager that has shown encouraging safety, tolerabilit...
Final efficacy results of the real-life ambispective urban study on frontline obinutuzumab-based immunochemotherapy for advanced follicular lymphoma
Abstract Background: The GALLIUM trial established obinutuzumab-based immunochemotherapy as a new standard of care in first-line treatment f...
Association between monoclonal gammopathy of undetermined significance and cardiovascular disease risk among individuals with type 2 diabetes: A Taiwan nationwide Study
Abstract Introduction: Monoclonal gammopathy of undetermined significance (MGUS) is associated with increased risk of cardiovascular disease...