Blood
Articles in this Issue
Impact of dementia on in-hospital outcomes in hematopoietic stem cell transplant (HSCT) recipients: A nationwide cohort study
Abstract Background Hematopoietic stem cell transplant (HSCT) is a curative treatment for many hematologic diseases but requires rigorous me...
Beyond approval: Lymphoma drugs and real-world representation (2015–2025)
Abstract INTRODUCTION Clinical trial generalizability remains an unmet goal in oncology clinical research. Generalizability refers to the abi...
Survival outcomes following second hematopoietic cell transplantation in lymphoma and leukemia: A single-center analysis
Abstract Background: Allogeneic hematopoietic cell transplantation (allo-HCT) offers curative potential for aggressive hematologic malignanc...
Treatment of pediatric patients (pts) with relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) with obecabtagene autoleucel (obe-cel), a CD19-directed chimeric antigen receptor (CAR) T-cell therapy: Preliminary findings from the Phase Ib/II CATULUS trial
Abstract Background: Obe-cel is an autologous, fast off-rate 4-1BB-ζ CD19-directed CAR T-cell therapy that demonstrated long-term efficacy an...
Azin1/tecr reprograms fatty acid metabolism to drive Acute Myeloid Leukemia progression
Abstract Acute myeloid leukemia (AML) is a clonal hematopoietic stem/progenitor cell disorder driven by aberrant proliferation, and undergoe...
FLT3-F691L confers kinase-independent resistance via Grb2-dependent MAPK signaling in AML
Abstract FMS-like tyrosine kinase 3 (FLT3) mutations occur in ~20–30% of acute myeloid leukemia (AML) cases and have been effectively target...
Emicizumab prophylaxis in pups and mtps with severe haemophilia: The pednet real world experience in 80 infants
Abstract Emicizumab (Hemlibra®, Roche) is a humanized bispecific antibody used for subcutaneous prophylaxis in children of any age and adult...
Improving karyotype success for myelomatch: Evidence-based culturing optimization for rapid AML screening - an NCI myelomatch and SWOG report
Abstract Introduction As a key screening test for the NCI myeloMATCH clinical trial, karyotyping detects aberrations at single-cell resolutio...
Luspatercept for the treatment of transfusion-dependent anemia in patients with myelodysplastic neoplasms with del5q, refractory/resistant/intolerant to prior treatments (QOL-ONE Phoenix)
Abstract Background: Myelodysplastic neoplasms (MDS) with deletion 5q (del5q) are characterized by <5% bone marrow blasts and either...
An immunometabolic companion biomarker to enhance FDG-PET interpretation and guide frontline therapy in follicular lymphoma
Abstract Introduction: Bendamustine-based immunochemotherapy (ICT) is a standard frontline regimen for follicular lymphoma (FL) but has limi...
Application of hi-c sequencing to detect cryptic and novel structural aberrations in lymphoid neoplasms
Abstract Background: The diagnosis of lymphoid malignancies primarily relies on histopathologic evaluation, immunophenotypic profiling, and...
Mortality trends in patients with co-occurring hematologic malignancies and heart failure in the United States population: A 25-year analysis using the CDC wonder database
Abstract Background: Hematologic malignancies (HM), also known as blood cancers, primarily include leukemia, lymphoma, and multiple myeloma....
Development of novel MZB1-directed HLA-dependent CAR T cell and CAR enhancer therapy in MM and other B-cell malignancies
Abstract BCMA-directed CAR T cell therapies have improved outcomes for multiple myeloma (MM), and several other targeted CAR T cell therapie...
Osimertinib synergizes selinexor on anti-tumor effect by targeting c-MYC in T-cell acute lymphoblastic leukemia
Abstract Background Adult T-cell acute lymphoblastic leukemia (T-ALL), a hematological malignancy derived from T lymphoc...
Impact of pre-transplant anxiety and depression on outcomes of AML patients after allogeneic transplantation
Abstract Introduction: Allogeneic stem cell transplantation (Allo-SCT) in Acute Myeloid Leukemia (AML) is an important part of the treatment...
Fedratinib in combination with CC-486, an oral hypomethylating agent, in patients with accelerated phase myelofibrosis: Results from the phase I/II famy trial
Abstract About 20% of myelofibrosis (MF) patients (pts) progress to MPN-blast phase (MPN-BP) which is preceded by an accelerated phase (MPN-...
Novel use of low-dose cidofovir (2.5 mg/kg Weekly) as CMV prophylaxis in the pre-engraftment Phase of stem cell transplantation: A viable alternative when ganciclovir is contraindicated and letermovir is not available
Abstract Background: Cytomegalovirus (CMV) infection in the pre-engraftment phase of hematopoietic stem cell transplantation (HSCT) poses a...
Mosunetuzumab and lenalidomide combination therapy augments CD8+ T cells with enhanced T cell-dependent cytotoxicity against follicular lymphoma cells
Abstract Introduction Follicular lymphoma (FL) represents most common form of indolent non-Hodgkin lymphoma. Despite sig...
Real-world outcomes in relapsed/refractory multiple myeloma: Retreatment versus no retreatment with an anti-CD38 monoclonal antibody in the 2L and 3L in patients from the Flatiron Health database
Abstract Introduction: A growing number of patients (pts) with multiple myeloma (MM) receive anti-CD38 monoclonal antibodies (mAbs) in early...
Mechanistic study of the Cullin3-CRL3^KEAP1-NRF2 neddylation axis in chemotherapy resistance of Acute Myeloid Leukemia stem cells
Abstract Cullin3-CRL3^KEAP1-NRF2 neddylation axis is a core mechanism of chemotherapy resistance in leukemia stem cells (LSCs), and targetin...
Better renal response with daratumumab in patients with monoclonal immunoglobulin deposition disease
Abstract Background: Monoclonal Immunoglobulin deposition disease (MIDD) is characterized by non-amyloidogenic linear amorphous deposition o...
PARP inhibitors and the rising incidence of secondary myelodysplastic syndrome and acute myeloid leukemia: A comprehensive meta-analysis
Abstract Background: Poly (ADP-ribose) polymerase inhibitors (PARPi) have transformed the management of BRCA-mutated ovarian and breast canc...
Fixed-duration epcoritamab monotherapy induces high response and MRD-negativity rates in elderly patients with newly diagnosed large B-cell lymphoma (LBCL) and comorbidities: Results from EPCORE DLBCL-3
Abstract Introduction: A proportion of newly diagnosed (1L) patients (pts) with LBCL are ineligible for standard curative chemotherapy with...
Survival determinants of hepatosplenic t-cell lymphoma (HSTCL): Analysis of an updated real-world pooled database
Abstract Background: Hepatosplenic T-cell lymphoma (HSTCL) is a rare and highly aggressive peripheral T-cell lymphoma ch...
Bone mineral density findings in patients with sickle cell disease
Abstract Background: Individuals with sickle cell disease (SCD) are at an increased risk of low bone mineral density (BM...