Blood
Articles in this Issue
Facility-level variation in hepatosplenic T-cell lymphoma care: Comparative outcomes from academic and community cancer centers
Abstract Background Hepatosplenic T-cell lymphoma (HSTCL) is a rare, aggressive peripheral T-cell lymphoma subtype with...
Efficacy and safety of luspatercept in the treatment of anemia in allo-HSCT for patients with hematological diseases
Abstract Background: Persistent anemia affects up to 30% of long-term survivors after allogeneic hematopoietic stem-cell transplantation (al...
Rituximab for KSHV-associated multicentric castleman disease: A phase II safety/efficacy trial
Abstract Objectives: HIV-associated multicentric Castleman disease (MCD) has recently been recognized as an important emerging comorbidity i...
Uneven gains: Disparities in pneumonia-associated mortality among myeloid leukemia patients in the United States, 1999–2020 — a CDC wonder and joinpoint analysis
Abstract Introduction Patients with myeloid leukemia are highly susceptible to infectious complications due to their imm...
Association of the easix score with survival and adverse outcomes in a large elderly hispanic cohort of patients with multiple myeloma.
Abstract Background: Risk stratification in multiple myeloma (MM) is critical for guiding treatment decisions. The Endothelial Activation and...
Quality of life in multiple myeloma: A scoping review
Abstract Background With the increasing availability of novel therapies for multiple myeloma (MM), MM is transitioning i...
Glucose-6-phosphatase dehydrogenase [G6PD] serum level predicts acute monocytic leukemia differentiation.
Abstract Introduction: Acute Myeloid Leukemia [AML] leukemogenesis follows differentiation fate that resembles normal hematopoiesis, albeit...
Sickle cell disease and atrial fibrillation: A national perspective on catheter ablation utilization and comorbidities
Abstract Background: Patients with sickle cell disease (SCD) are at increased risk of atrial fibrillation (AF). Catheter ablation is a well-...
Low-dose oral decitabine and cedazuridine among patients with low-risk myelodysplastic syndromes
Abstract Background: Parenteral DNA methyltransferase inhibitors (DNMTi) such as azacitidine and decitabine (DEC), including an attenuated 3...
Paroxysmal nocturnal hemoglobinuria: Transplant experience using post-transplant cyclophosphamide in a resource-limited setting
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a chronic, debilitating clonal hematopoietic stem cell disorder characte...
Evaluating the safety and tolerability of switching from emicizumab to fitusiran prophylaxis in adult males with severe hemophilia A, with or without inhibitors: SWITCH study, a trial in progress
Abstract Introduction As the treatment landscape of hemophilia non-factor therapies expands, there is a growing need to improve understandin...
Impact of asparaginase discontinuation on outcomes in pediatric B-cell precursor acute lymphoblastic leukemia: Post hoc analysis of the JCCG ALL-B12 Study
Abstract Background Asparaginase (Asp) is a key component in the treatment of children with acute lymphoblastic leukemia (ALL), particularly...
Estimated total cost of care and patient out-of-pocket cost savings with first-line fixed duration venetoclax + obinutuzumab compared with treat-to-progression BTKi regimens among Medicare-eligible patients with chronic lymphocytic leukemia in the United States following the Inflation Reduction Act.
Abstract Background: In a recently published United States (US) population model of patients with previously untreated chronic lymphocytic l...
Management and long-term hematologic and neurologic outcomes of IgM-related neuropathy: A single center experience
Abstract Background: IgM-related neuropathy is associated with the presence of IgM monoclonal paraprotein [IgM monoclonal gammopathy of unde...
Prognostic relevance of mutational profile in secondary Acute Myeloid Leukemia patients treated with CPX-351.
Abstract Introduction and aims Acute Myeloid Leukemia (AML) is a heterogeneous disease, driven by the serial acquisition of somatic mutation...
Development of a novel CAR-T cell therapy using a multimodal approach to target T cell lymphoma
Abstract INTRODUCTION Relapsed/refractory T cell lymphoma (TCL) patients (both peripheral and cutaneous TCL) are aggressive malignancies wit...
Preservation of gonadal function following chemotherapy protocols with acvd and acvd-BV in adults diagnosed with advanced-stage Hodgkin lymphoma: A single center experience.
Authors: Maryam Almutairi 1234, Mohammed AlHarbi1234, Abdullah Alsaleh1234, Mohsen Alzahrani1234, Bader Alahmari1234, Hind Salama1234, Abdulrahman Alraizah1234, Ayman Ibrahim1234,...
Comparative risk of thrombosis in adults with primary immune thrombocytopenia treated with eltrombopag versus romiplostim: A target trial emulation in the french adult immune thrombocytopenia (FAITH) cohort
Abstract Background : Immune thrombocytopenia (ITP) is a rare autoimmune disease, leading to bleeding and paradoxically to thrombosis. Eltro...
Single-cell multiomics reveals candidate cis-regulatory elements in NPM1-mutant AML
Abstract Acute myeloid leukemia (AML) is driven by diverse genetic alterations in hematopoietic precursor cells and has a high rate of relap...
Delta opiod receptor signaling modulates myeloid suppression in Myelodysplastic Syndromes
Abstract Myelodysplastic syndromes (MDS) are diseases for which innate immunity has been clearly established to be critical in its pathogene...
The score settles it? maybe not: Navigating postpartum VTE prophylaxis
Abstract Background: The risk of venous thromboembolism (VTE) increases during pregnancy and continues to rise throughout pregnancy with max...
Patterns of minimal residual disease trajectories in 323 newly diagnosed patients with multiple myeloma and correlation with progression-free survival
Abstract Introduction Minimal residual disease (MRD) is a sensitive tool for evaluating treatment response in multiple m...
PPP1R15A as a therapeutic target to overcome chemoresistance in AML: An in vitro study
Abstract Introduction: Acute myeloid leukemia (AML) is often characterized by impaired DNA damage response (DDR), promoting chemoresistance...
Epigenetic silencing via SP140 and H3K27me3 restricts immunogenic viral antigen expression in EBV+ lymphomas
Abstract Epstein-Barr virus (EBV) infection is implicated in the pathogenesis of a significant subset of human lymphomas. EBV+ tumors exhibi...
Treatability with ibrutinib plus venetoclax in patients with CLL in the real-world. the eric international thrive study
Abstract Background. Clinical trials have documented the efficacy of ibrutinib in combination with venetoclax in CLL. Indeed, Ibrutinib plus...