Blood
Articles in this Issue
Polyunsaturated fatty acids control lipid membrane dynamics and ferroptosis sensitivity in B-cell lymphoma
Abstract Background and Significance: Induction of ferroptosis, a form of cell death driven by iron-dependent peroxidation of polyunsaturate...
Redefining function high-risk (FHR) multiple myeloma (MM) in the context of upfront quadruplet (QUAD) therapy and autologous stem cell transplantation (ASCT)
Abstract Introduction Functional high-risk MM (FHR) is currently defined as relapse within 18 month (mo) of induction therapy irrespective o...
Diagnostic conformity to who criteria and use of cytoreductive therapy in classical myeloproliferative neoplasms: Experience from a resource-limited country
Abstract Background: Classical myeloproliferative neoplasms (MPNs); polycythemia vera (PV), essential thrombocythemia (ET) and primary myelo...
Racial and socioeconomic disparities in incidence and survival of splenic marginal zone lymphoma : United States national database analysis
Abstract Background: Splenic marginal zone lymphoma (SMZL) is a rare indolent B cell neoplasm. There has been limited in...
Real-world outcomes and prognostic factors in older adults with early-stage classic Hodgkin lymphoma: A study from the spanish relinf-geltamo registry
Abstract INTRODUCTION Older adults (≥60 years) represent up to a quarter of all classic Hodgkin lymphoma (cHL) cases in Western countries and...
Effectiveness of thrombopoietin (TPO) in stem cell mobilization for multiple myeloma and lymphoma patients
Abstract Background: Thrombopoietin (TPO) shows promise for hematopoietic stem cell mobilization. This study evaluated TPO as a single-agent...
PROK1 locus variant identified as a genetic determinant of anthracycline-related cardiomyopathy in long-term childhood acute leukemia survivors
Abstract Introduction Survival rates for childhood and adolescent acute leukemia have significantly improved over the pa...
Three decades of allogeneic transplantation showing improved survival, persistent relapse and post‑relapse outcomes of donor lymphocyte infusion versus second transplant
Abstract Background: Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only potentially curative therapy for high-risk he...
Trium study: Exploring MRD-guided triplet therapy with sonrotoclax, zanubrutinib, and CD20mab in Untreated Mantle Cell Lymphoma: A prospective, multicenter, Phase II Study
Abstract Background Targeted therapy-based induction regimens provide novel treatment options for newly diagnosed mantle...
A novel spontaneous HLH mouse model by engrafting human HSCs into b-ndg MGMT3 mice
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome with an...
Functional inactivation of duodenal ferroportin by hepcidin drives iron-dependent degradation of DMT1 in lysosomes
Abstract Hepcidin regulates systemic iron homeostasis by inhibiting iron absorption and recycling through degradation of the iron exporter f...
PORT-77 is a potent inhibitor of ABCG2 that reduces efflux of protoporphyrin IX from erythrocytes of patients with protoporphyria and reduces plasma protoporphyrin IX levels in healthy human subjects
Abstract Background: PORT-77 is a novel, orally bioavailable inhibitor of the ATP-binding cassette subfamily G member 2...
Prognostic impact of pre-transplant IPSS-m risk downstaging in Myelodysplastic Syndromes
Abstract Introduction Mutations incorporated risk stratification tool in MDS (IPSS-M) have offered greater prognostic pr...
Real‑world matched comparison of talquetamab versus teclistamab in Relapsed/Refractory multiple myeloma
Abstract Introduction Teclistamab is a bispecific B-cell maturation antigen (BCMA)-directed CD3 T-cell engager, and the...
The role of hematopoietic stem cell transplantation in peripheral T-cell lymphoma not otherwise specified
Abstract Introduction Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) is the most common subtype of peripheral T-cell lymphoma...
Discovery and preclinical characterization of SB-01, a novel allosteric inhibitor of human factor XIa
Abstract Human factor XI (hFXI) is a key protein in the intrinsic coagulation pathway that amplifies clot formation under pathological condi...
Red cell rheology predicts acute chest syndrome and vaso-occlusive events in sickle cell disease
Abstract Sickle cell disease (SCD) is an autosomal recessive disorder characterized by rigid, poorly deformable red blood cells (RBC); worse...
Venetoclax pharmacokinetics with triazole prophylaxis in patients with Acute Myeloid Leukemia in India: Pilot study
Abstract Venetoclax (VEN) combined with a hypomethylating agent is standard induction therapy for patients with acute myeloid leukemia (AML)...
Feasibility of characterizing von Willebrand disease using high-throughput affinity-based proteomics
Abstract Background: Von Willebrand disease (VWD) is the most common inherited bleeding disorder, caused by quantitative or qualitative defe...
Frailty as a prognostic factor in younger adult patients with Acute Myeloid Leukemia undergoing allogeneic stem cell transplantation
Abstract Introduction Acute myeloid leukemia (AML) is potentially curable with allogeneic stem cell transplantation (alloHCT); however, its...
Atypical neurotoxicity in CAR-T cell therapy: A retrospective analysis of unusual icans presentations and their clinical implications
Abstract Background: Chimeric Antigen Receptor T-cell (CAR-T) therapy is a transformative treatment for relapsed/refractory Non-Hodgkin Lymp...
Characterizing a racially diverse cohort of patients with AL amyloidosis treated with dara-VCD
Abstract AL amyloidosis is a rare but life-threatening plasma cell disorder characterized by the deposition of misfolded immunoglobulin ligh...
Multi-centre real-world outcome of patients with Richter transformation receiving CD19-directed commercial CAR T-cell therapy in Australia.
Abstract Aim: Richter transformation (RT) is an uncommon (2-10%) complication of chronic lymphocytic leukemia (CLL), most frequently manifes...
Docirbrutinib (AS-1763), a novel non-COVALENT BTK inhibitor, demonstrates efficacy in BTK inhibitor-resistant mutant cells
Abstract Background: Bruton's tyrosine kinase inhibitors are a standard therapy for chronic lymphocytic leukemia (CLL). Despite their effica...
Travel distance to treatment center does not independently impact survival in Acute Myeloid Leukemia (AML): A national cancer database (NCDB) analysis
Abstract Introduction AML is an aggressive hematologic malignancy that requires frequent hospitalizations, close monitoring, and complex sup...