Blood
Articles in this Issue
Clinical characteristics and outcomes of extranodal marginal zone lymphoma of pulmonary mucosa-associated lymphoid tissue: A single-center retrospective study
Abstract Introduction: Extranodal marginal zone lymphoma of pulmonary mucosa-associated lymphoid tissue (MALT) is a rare, indolent lymphopro...
Peripartum FXI replacement supports safe neuraxial anesthesia in FXI-deficient parturients
Abstract Introduction Factor XI deficiency is an autosomal recessive bleeding disorder that poses challenges in peripartum management due to...
Monitoring of CNS involvement in AML using ultrahigh-sensitivity next-generation sequencing of cell-free DNA
Abstract Introduction: Evaluation and monitoring of central nervous system (CNS) involvement in AML patients with standard of care methods (c...
Topical cyclosporine vs tacrolimus for ocular GVHD prophylaxis after outpatient allogeneic hematopoietic stem cell transplantation: A Phase I–II trial
Abstract Background Ocular graft-versus-host disease (oGVHD) is a common complication after allogeneic hematopoietic ste...
Garp/LRRC32 defines the erythroid-megakaryocyte fate decision and enables β-globin program activation
Abstract Erythroid commitment from multipotent progenitors is a tightly regulated process, yet the molecular drivers during the earliest sta...
Human HSPCs CRISPR-engineered to endogenously express oncogenic NRAS generate a transplantable lethal myeloid malignancy targetable with novel RAS therapeutics
Abstract Introduction: NRAS mutations are frequently found in human leukemias, including 20-30% of acute myeloid leukemia (AML) patients and...
Machine learning-based novel surfaceome classification system for acute myeloid leukemia
Abstract Objectives: Immunophenotyping of acute myeloid leukemia (AML) currently relies heavily on a limited panel of validated surface mark...
Molecular mutations may influence cytokine expression and critical illness subphenotyping in septic patients with Acute Myeloid Leukemia
Abstract Background: In acute myeloid leukemia (AML), mutations in IDH1/2, RAS-family, FLT3, and TP53 have all been associated with unique in...
All-trans retinoic acid for refractory cancer therapy-induced thrombocytopenia: A new option beyond TPO-ras?
Abstract Background: Cancer therapy-induced thrombocytopenia (CTIT) is a common hematologic toxicity in patients with solid tumors. It often...
Identification and characterization of human erythroblastic islands (EBIs) at single cell resolution
Abstract Nearly all red cell production takes place within erythroblastic islands (EBIs), a structure comprised of a central macrophage (CM)...
Single-cell RNA sequencing reveals cellular heterogeneity and molecular features of extramedullary-involved multiple myeloma
Abstract Objective: Extramedullary multiple myeloma (EMM) is a highly aggressive subtype of multiple myeloma (MM), characterized by the diss...
Sustained MRD negativity via multimodal NGS/NGF overcomes high-risk cytogenetics and predicts long-term survival in transplant-eligible multiple myeloma: A real-world cohort study
Abstract Background: Dozens of clinical trials demonstrated that achievement of MRD negativity represents a paradigm shift in MM therapeutic...
Lentiviral hematopoietic stem and progenitor cell gene therapy with Etuvetidigene autotemcel for the treatment of Wiskott-Aldrich Syndrome
Abstract BACKGROUND Wiskott-Aldrich Syndrome (WAS) is a rare, X-linked, life-threatening inborn error of immunity and pl...
Bioflipi scores define distinct immune profiles in follicular lymphoma
Abstract Despite a characteristic indolent course, a substantial subset of follicular lymphoma (FL) patients has an early relapse with a poo...
Renal amyloidosis-related mortality trends and disparities: A retrospective nationwide analysis using the CDC wonder database
Abstract Background Renal amyloidosis is a rare but life-threatening condition characterized by extracellular deposition...
Methimazole-triggered pancytopenia in a long-term methotrexate user: Dual-agent myelotoxicity
Abstract Background: Methotrexate (MTX), a mainstay in the treatment of autoimmune disorders such as rheumatoid arthritis, is generally well...
Favorable Outcomes of Bridging Glofitamab Prior to anti-CD19 CAR-T cell Therapy in patients with non-Hodgkin lymphoma
Abstract Introduction: Chimeric antigen receptor (CAR) T-cells have improved outcomes of patients (pts) with relapsed/re...
Disseminated intravascular coagulation: An uncommon initial manifestation of AML presenting with embolic stroke
Abstract Introduction: Disseminated intravascular coagulation (DIC) is classically associated with acute promyelocytic leukemia (APL), but i...
Uncovering idiopathic hypereosinophilic syndrome: A diagnostic journey through eosinophilia .
Abstract Eosinophilia is defined as an increase in the eosinophil count in the peripheral blood, specifically characterized by an absolute e...
Novel therapeutics for SF3B1 mutant cancers which exploit the missplicing of DCAF16
Abstract Oncogenic mutations of the core RNA splicing factor SF3B1 are common in myeloid cancers, chronic lymphocytic leukemia (CLL) and sel...
FLAG-mitoxantrone combined with low-dose venetoclax (7 Days): A highly efficient regimen and excellent bridge for allogeneic hematopoietic transplant for newly diagnosed and relapsed/refractory AML.
Abstract Background FLAG (G-CSF, Fludarabine, Cytarabine) combined with either Idarubicin (Ida) or Mitoxantrone (Mitox) were reported to be...
DDX41-R525H mutation promotes dysplastic hematopoiesis via aberrant splicing of key regulators of HSC biology
Abstract Germline mutations in the RNA helicase DDX41 are the most common genetic predisposition to myelodysplastic syndromes (MDS) and acut...
Development and prospective validation of a prognostic model for diffuse alveolar hemorrhage after allogeneic hematopoietic stem cell transplantation
Abstract Introduction Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication that can occur after allogeneic hematop...
Multi-omic analysis reveals metabolic fitness of the ARI0002h BCMA CAR T-cell infusion product as a key predictor of clinical outcomes in multiple myeloma
Abstract Background BCMA-directed CAR-T therapies have achieved high initial responses in relapsed/refractory (R/R) multiple myeloma (MM). A...
Clinical value of advanced genomic testing in adult Philadelphia-negative B-ALL: Results from the CZ national leukemia study group (CELL)
Abstract IntroductionB-cell precursor acute lymphoblastic leukemia (B-ALL) in adults is a biologically and clinically heterogeneous disease....