Blood
Articles in this Issue
Susoctocog alfa for major surgery in acquired Hemophilia A
Abstract Acquired hemophilia A (AHA) is a rare but serious bleeding disorder caused by autoantibodies against coagulation factor VIII (FVIII...
Association of opioid use disorder and thrombotic events in hospitalized patients: A national inpatient database study
Abstract Introduction Thrombotic events, such as deep vein thrombosis (DVT), pulmonary embolism (PE), and arterial throm...
Enhanced chimerism detection with multiple single Nucleotide Polymorphism Sequencing: Improving risk stratification post-allogeneic hematopoietic stem cell transplantation
Abstract Introduction Chimerism (CHIM) analysis following allogeneic hematopoietic stem cell transplantation (aHSCT) is critical for assessi...
Paused RNA polymerase II enables flexible lineage decisions but also underlies oncogenic vulnerabilities in human hematopoiesis
Abstract During inflammation, hematopoietic stem cells (HSCs) must integrate environmental stimuli to generate the appropriate myeloid and l...
Lentiviral vectors engineered for direct In Vivo delivery to resting T cells
Abstract Direct in vivo T cell engineering offers a new paradigm for CAR T delivery. We have evaluated several approaches to engineer lentiv...
Spontaneous remissions in paroxysmal nocturnal hemoglobinuria: True remission or clonal evolution to malignancy?
Abstract Background Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic disorder driven by a deficiency of glycosylphos...
Intermediate-dose (0.4 g/kg per Dose) versus standard high-dose (1.0 g/kg per Dose) intravenous immunoglobulin in pediatric primary immune thrombocytopenia: A multicenter randomized non-inferiority trial
Abstract Background and Objectives Children presenting to emergency departments with newly diagnosed immune thrombocytop...
Real-world use of loncastuximab tesirine in heavily pretreated and high risk relapsed/refractory large B-cell lymphoma patients: German multicenter analysis
Abstract Patients (pts) with large B-cell lymphoma (LBCL) relapsing or being refractory (r/r) following two prior systemic therapies are par...
Decoding CAR t cell membrane architecture with the proximity network assay
Abstract Membrane protein organization plays a critical role in shaping CAR T cell function, yet current tools lack the resolution to study...
Risk of death and comorbidities in β-thalassemia carriers identified by consecutive genotyping: A prospective cohort study of 467,242 general population individuals
Abstract Introduction:Approximately 1.5% of the global population are heterozygous carriers of β-thalassemia. While the condition is typical...
Characterization of the germline and somatic mutation profile of diamond-blackfan anemia
Abstract Diamond-Blackfan Anemia (DBA) is a ribosomopathy characterized by isolated hypoplastic anemia, phenotypic abnormalities and cancer...
A phase I monotherapy study assessing the safety and efficacy of GR1803, a BCMA×CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma
Abstract Background: Outcomes remain poor for patients with relapsed or refractory Multiple Myeloma (RRMM). GR1803 is a BCMA x CD3 bispecifi...
A real-world multi-institution experience of standard vs alternative dosing of inotuzumab ozogamicin for Relapsed/Refractory pediatric B-cell acute lymphoblastic leukemia
Abstract Background: Inotuzumab ozogamicin (InO) is an active agent in children and adults with relapsed/refractory (R/R) B-cell acute lymph...
Pre-transplant MRD negativity predicts favorable outcomes of CAR-T therapy for pediatirc relapsed and Refractory Acute lymphoblastic leukemia followed by TCRαβ-depleted haplo-HSCT
Abstract Background and aim: TCRαβ-depleted HLA-haploidentical stem cell transplantation(TCD Haplo-HSCT) represents a promising curative opt...
Tislelizumab combined with zanubrutinib and high-dose methotrexate in newly diagnosed primary central nervous system DLBCL: A phase 2 study
Abstract Background: Primary central nervous system diffuse large B-cell lymphoma (PCNS-DLBCL) is a rare subtype of non-Hodgkin lymphoma wit...
Real-world patient-based next-generation sequencing assessments identify a high-risk subgroup and associated gene signature in diffuse large B cell lymphoma
Abstract Diffuse large B cell lymphoma (DLBCL) exhibits profound genetic heterogeneity that drives disparate clinical outcomes despite stand...
Relapsed acute lymphoblastic leukemia treated with venetoclax and navitoclax: Results of the raven study in children and young adults with relapsed/ refractory ALL
Abstract Acute lymphoblastic leukemia (ALL) is the most common malignancy of childhood. While frontline therapy is highly effective, 10-20%...
More than iron: Embedding gynecologic care in a telemedicine IDA platform
Abstract e-Iron is a telemedicine platform developed at our institution to facilitate the administration of intravenous iron (IVI) to approp...
A novel predictive model for posttransplant lymphoproliferative disorder in the letermovir prophylaxis era
Abstract Introduction Posttransplant lymphoproliferative disorder (PTLD) is a complication following allogeneic hematopoietic stem cell tran...
Adjudicated clinical outcomes of plasma microbial cell-free DNA surveillance in neutropenic patients with Acute Myeloid Leukemia undergoing outpatient chemotherapy
Abstract Background/Objectives: The main objective of this proof-of-concept study is to assess the clinical impact of microbial cell-free DN...
Prolonged cytopenias after BCMA CAR‑T are associated with impaired endogenous T cell recovery characterized by decreased CD8+ T cell diversity
Abstract Chimeric antigen receptor T cells (CAR-T) targeting B-cell maturation antigen (BCMA) have transformed the treatment landscape for m...
Prenatal transplantation of a clinical cell product engineered to secrete FVIII in a sheep with Hemophilia A corrects the severe bleeding phenotype and prevents hemarthroses
Abstract Prenatal treatment (PNT) of people with hemophilia A (HA) is a feasible, safe, yet unexplored clinical approach, consisting of an u...
Adapting the American society of hematology crti-la model to build clinical research capacity in Mexico: Results from the ameh-I3 course
Abstract Introduction: Building research capacity is essential for advancing evidence-based clinical practice. However, access to structured...
Beyond complement: Patient and in vitro evidence for alternative mechanisms of Monocyte–Platelet aggregation in PNH
Abstract Background: Paroxysmal nocturnal haemoglobinuria (PNH) is a clonal haematopoietic stem cell disorder characterised by the absence o...
Klippel-trenaunay syndrome with multifactorial anemia:successful management with sirolimus
Abstract Objective：Klippel-Trenaunay Syndrome (KTS), a rare congenital disorder characterized by capillary malformations, venous varicositi...