Blood
Articles in this Issue
Allo-HCT outcomes for AML patients with NUP98 rearrangements: A study on behalf of the global committee, the ALWP and the PDWP of the EBMT
Abstract Background Acute myeloid leukemia (AML) with NUP98 rearrangements on chromosome 11p15 is a high-risk subtype with poor prognosis. D...
Socio-clinical determinants and demographic disparities of survival in splenic marginal zone lymphoma: A retrospective cohort study
Abstract Background: Splenic marginal zone lymphoma (SMZL) is an uncommon, typically indolent type of B-cell lymphoma originating in the sple...
Hepatic intravital imaging reveals the contribution of peptidylarginine deiminase 4 (PAD4) to the spatiotemporal dynamics of neutrophil recruitment and NET release during bacterial infection
Abstract Background: Intravital imaging is a powerful tool for investigating dynamic biologic processes such as neutrophil (PMN) recruitment...
Survival difference among patients with large B-cell lymphoma (LBCL) based on first-line clinical trial participation: A multi-institutional analysis of 8 academic institutions in the lymphoma epidemiology of outcomes (LEO) cohort
Abstract Background: Despite advances in LBCL treatment, 35–45% of patients relapse or have refractory disease highlighting an unmet clinica...
CD19/CD22 CAR-T cells in adult patients with relapsed/refractory B-cell malignancies
Abstract Background: Dual-targeted CAR-T cell therapies may help overcome mechanisms of resistance associated with antigen escape. We evalua...
Autologous and allogeneic stem cell transplantation for ALK-positive anaplastic large cell lymphoma: An analysis of the EBMT lymphoma working party
Abstract Background Adults with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma (ALK-pos. ALCL) treated with CHOP or vari...
Artificial intelligence‑driven virtual tumor board enhances precision care in myelodysplastic syndromes (MDS)
Abstract Background and Aims Myelodysplastic syndromes (MDS) present significant diagnostic and therapeutic challenges, often requiring inpu...
Commpass explorer: An interactive platform to explore clinico-genomic data from newly diagnosed multiple myeloma patients from the commpass observational trial
Abstract The CoMMpass study (NCT01454297) is a prospective, longitudinal observational trial involving 1,141 newly diagnosed, treatment-naïv...
Diverse preferences for treatment options in relapsed/refractory (R/R) follicular lymphoma (FL): Survey results from patients in the United States (US)
Abstract Background: Since 2020, several novel treatments (Txs) that differ in duration, dosing frequency, route of administration, efficacy...
FLIPI24 as a prognostic model in marginal zone lymphoma: Results from an international multi-cohort analysis
Abstract Introduction Marginal zone lymphoma (MZL) is an indolent and heterogenous disease. Several prognostic models have been proposed to...
CD123-directed chimeric antigen receptor T-cell (CART123) therapy for relapsed/refractory pediatric acute myeloid leukemia
Abstract Introduction Clinical outcomes of children, adolescents and young adults (CAYA) with second or greater relapsed or refractory (r/r)...
Reassessing bone marrow staging practices in limited-stage follicular lymphoma in the PET era
Abstract Introduction: Bone marrow (BM) involvement is present in approximately 50% of patients with follicular lymphoma (FL) and is associa...
Comparison of alemtuzumab and ATG-based conditioning in adult recipients of allogeneic hematopoietic cell transplantation (HCT) for severe aplastic anemia: A retrospective study
Abstract Background The optimal in-vivo T-cell depleting agent for allogeneic hematopoietic cell transplantation (HCT) for patients with sev...
Early efficacy and safety of luspatercept in myelofibrosis-associated anemia: A clinical study with biomarker exploration
Abstract Background: Anemia is a prevalent and prognostically adverse complication in myelofibrosis (MF). Although preliminary studies sugge...
Identification of small molecules that selectively target JAK2V617F driven cytokine-independent megakaryopoiesis by leveraging single cell RNA sequencing maps of myelofibrosis patients samples and a deep learning framework
Abstract In myeloproliferative neoplasms including myelofibrosis (MF), the accumulation of driver mutations like JAK2V617F in the hematopoie...
Tradeoff between vaccine-induced immunity and depth of response following autologous stem cell transplantation in multiple myeloma
Abstract Introduction: Immunizations are routinely administered to confer protection against vaccine-preventable infections during both early...
Real-life CD34+CD38- leukemic stem cell (LSC) flow quantification in adult AML at diagnosis independently predicts survival of intensively but not AZA-VEN treated patients: A study of prospective observational ALFA-PPP acute leukemia french association
Abstract Introduction CD34+CD38- leukemic stem cell (LSC) is a key prognostic marker in AML at diagnosis and follow-up in intensive clinical...
Impact of pain sensitization phenotypes on quality of life among adults with sickle cell disease
Abstract Introduction: Recent research has shown that sensitization contributes to chronic pain phenotypes in adults with sickle cell diseas...
The phase II study of zanubrutinib combined with R-CHOP in previously untreated diffuse large B-cell lymphoma (DLBCL) patients with specific gene-expression
Abstract Background: Diffuse Large B cell Lymphoma (DLBCL) is the most common type of non-Hodgkin Lymphoma (NHL), with R-CHOP chemotherapy (...
Interrelationship between endothelial dysfunction and inflammation and outcomes in pulmonary embolism
Abstract Introduction: Acute pulmonary embolism (PE) is the third leading cause of death with a mortality rate upwards of 30% if left untrea...
DNA-based MRD monitoring enhances risk stratification during TKI dose reduction in CML: Evidence from the clinical trial
Abstract Background: In chronic myeloid leukemia (CML), DNA-based measurable residual disease (MRD) analysis—either combined with RNA MRD (M...
Laboratory characteristics of monoclonal gammopathy of undetermined significance (MGUS) in a diverse sample from three large cancer epidemiology cohorts.
Abstract Introduction: Monoclonal gammopathy of undetermined significance (MGUS) is a precursor of multiple myeloma (MM) and shares many ris...
Perioperative anemia and transfusion thresholds in vascular surgery procedures – a systematic review
Abstract Background Anemia is a common condition, with an estimated 1.92 billion cases, or 24.3% of the worldwide population as of 2021, and...
Incidence of CMV-reactivation in multiple myeloma patients receiving bispecific antibodies
Abstract Introduction: Cytomegalovirus (CMV) reactivation is common following allogenic hematopoietic stem cell transplant and CAR T-cell th...
Real-world efficacy of inaticabtagene autoleucel in adult B-cell acute lymphoblastic leukemia patients with high-risk molecular alterations
Abstract Background Adult patients with B-cell acute lymphoblastic leukemia (B-ALL) harboring high-risk molecular alterations face an unfavo...