Blood
Articles in this Issue
Outcomes of CAR-T therapy in HIV-positive multiple myeloma patients: A retrospective database analysis
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) therapy has redefined treatment for patients with relapsed...
Novel insights from the largest cohort to date: Elucidating risk factors, clinical outcomes, and prognostic predictors in autoimmune hemolytic anemia following allogeneic hematopoietic stem cell transplantation
Abstract Introduction Autoimmune hemolytic anemia (AIHA) is a rare yet serious hematologic disorder, defined as hemolytic anemia characteriz...
Comparative study of hetrombopag vs. eltrombopag in promoting platelet engraftment post-autologous hematopoietic stem cell transplantation: A multicenter clinical trial
Abstract Background and Purpose：Autologous hematopoietic stem cell transplantation (auto-HSCT) is an important therapeutic approach for dis...
Analysis of factors associated with clinical response in glofitamab's treatment of relapsed or refractory (R/R) large B-cell lymphoma
Abstract Abstract Diffuse large B-cell lymphoma (DLBCL) has achieved good treatment outcomes with anti-CD20 based chemoi...
Lipo-MIT-based bridging therapy enables effective CAR-T treatment in high-risk relapsed or refractory B-cell lymphoma
Abstract Background: Chimeric antigen receptor (CAR)-T cell therapy has significantly improved outcomes for relapsed or...
The role and mechanism of exosomal aminopeptidase n (APN/CD13)-mediated CTL cell dysfunction in aplastic anemia
Abstract Introduction Severe aplastic anemia (SAA) is a life-threatening bone marrow failure disorder, currently recognized to arise primari...
Sustained minimal residual disease (sMRD) negativity in transplant ineligible newly diagnosed multiple myeloma treated with isatuximab plus lenalidomide and dexamethasone with bortezomib (Isa-VRd) versus isa-rd: 12-24-month data from the phase 3 benefit trial (IFM 2020-05)
Abstract Introduction. Sustained minimal residual disease (sMRD) negativity has shown a stronger correlation with survival outcomes than MRD...
Creating a tool for measuring preferences for treating blood cancers in older adults using implementation science
Abstract Background: Older adults with blood cancers now face complex treatment decisions that require weighing benefits and risks of variou...
Genetic variants and hemoglobinopathies among Indian sickle cell disease patients: A systematic review
Abstract Background: Sickle Cell Disease (SCD) in India exhibits unique genetic and phenotypic diversity, shaped by the predominance of the...
Real-world efficacy and safety of pomalidomide-rituximab-based combination therapy in newly diagnosed extranodal diffuse large B-cell lymphoma
Abstract Introduction The R-CHOP regimen (rituximab, cyclophosphamide, doxorubicin/epirubicin, vincristine, and prednisone) has been establi...
ORM-1153: A CD123-targeting degrader antibody conjugate with GSPT1-degrading payload exhibits potent preclinical antitumor activity in Acute Myeloid Leukemia
Abstract Background: Acute myeloid leukemia (AML) is a devastating hematological malignancy with limited treatment optio...
Patterns of presentation, treatment, and survival in primary mediastinal B cell lymphoma: A colombian retrospective cohort
Abstract Introduction: Primary mediastinal B-cell lymphoma (PMBCL) is a rare and aggressive subtype of diffuse large B-cell lymphoma (DLBCL)...
Impact and predictors of icans on survival in lymphoma and myeloma patients treated with CAR T cell therapy
Abstract Background: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a frequent complication of CAR T-cell therapy, incide...
Discovery and preclinical characterization of orally bioavailable JAK2V617F mutant selective JH2 inhibitors with disease modification potential in myeloproliferative neoplasms
Abstract The JAK2V617F mutation is the most common genetic alteration in patients with myeloproliferative neoplasms (MPNs), present in &...
A patient-derived CRISPR platform reveals selective dependencies in Acute Myeloid Leukemia
Abstract Introduction: CRISPR/Cas9 screening is a powerful tool used to delineate genes critical for AML progression and drug resistance. How...
Racial and socioeconomic disparities in clinical trial participation and outcomes in systemic peripheral T-cell lymphoma (PTCL): A multicenter retrospective Study
Abstract Background: Peripheral T-cell Lymphoma (PTCL) is an aggressive and heterogenous disease with known survival disparities across raci...
Real-world efficacy and safety of carfilzomib-based combination regimens in patients with multiple myeloma
Abstract Background Multiple myeloma (MM), a heterogeneous malignancy originating from plasma cells in bone marrow, repr...
Monoclonal gammopathy in patients with type I gaucher disease: Data from the Russian gaucher registry
Abstract Background Gaucher disease (GD), a lysosomal storage disorder caused by deficient glucocerebrosidase activity, is associated with p...
Trends in mortality from deep vein thrombosis and pulmonary embolism as multiple causes of death in u.S. adults aged ≥65 years (1999–2023): A CDC wonder analysis
Abstract Background: Pulmonary embolism (PE), often arising as a complication of deep vein thrombosis (DVT) is a leading...
Overcoming barriers to clinical trial enrollment among adolescents and young adults with acute myeloid leukemia: Insights from a large academic cancer center
Abstract Background: Adolescents and young adults (AYAs, age 15-39 years) with acute myeloid leukemia (AML) experience disparities in outcom...
Fried's frailty phenotype predicts survival in pts with relapsed/refractory lymphoma or myeloma undergoing chimeric antigen receptor T-cell therapy – a prospective, observational Study
Abstract Chimeric antigen T-cell receptor (CART) therapy is highly effective for pts (pts) with relapsed/refractory (R/R) lymphoma/multiple...
Fixed-duration epcoritamab + R-CHOP in patients with newly diagnosed DLBCL and high IPI scores (3–5) led to sustained remissions and disease-free survival beyond 3 years: Results from the EPCORE NHL-2 trial
Abstract Introduction: Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is a standard of care (SOC) for pa...
USP28 inhibition upregulates CD20 via c-myc suppression and synergizes with anti-CD20 immunotherapy in B-cell lymphomas
Abstract Introduction Anti-CD20 monoclonal antibodies are widely used in the treatment of B-cell lymphomas, including diffuse large B-cell l...
The effect of steroid-induced hyperglycemia in early mortality during induction treatment of Philadelphia-negative acute lymphoblastic leukemia in Latino young adults
Abstract Introduction: Acute lymphoblastic leukemia (ALL) disproportionately affects Latino populations, who also exhibit a dismal prognosis...
Mitochondrial DNA heteroplasmy and haplogroup variation in pediatric Acute Myeloid Leukemia
Abstract Introduction: While somatic mutations in pediatric AML risk stratification have been extensively characterized, the role of heterop...