Blood
Articles in this Issue
Humanized KLKB1 provides a mouse model for evaluating the knockdown efficacy of RNAi therapies
Abstract Introduction: The KLKB1 gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fib...
Personalized Desensitization for DSAs in Allogeneic Blood or Marrow Transplantation: Impact on Graft Outcomes and Access to Transplant
Abstract Introduction: Donor-specific anti-HLA antibodies (DSAs) increase graft rejection risk in allogeneic blood or marrow transplantation...
A longitudinal study on the impact of hematopoietic stem cell transplantation on sickle cardiomyopathy
Abstract Introduction: Maladaptive cardiac remodeling in sickle cell disease (SCD) begins early in childhood, with a high cardiovascular dis...
Low incidence of HTLV-1 infection in Andean highlanders with NFKB1 haplotype
Abstract Human T-cell lymphotropic virus type I (HTLV-1) is a retrovirus infecting T-lymphocytes recognized as the causative agent of adult...
Preliminary safety and efficacy of ELVN-001, a selective active site inhibitor of BCR::ABL1, in patients with CML driven by atypical fusion transcripts
Abstract Introduction CML is characterized by a reciprocal translocation of t(9;22)(q34;q11), leading to the BCR::ABL1 fusion gene. Most pati...
TP53-mutated Acute Myeloid Leukemia through a single-cell lens
Abstract Introduction TP53 variants occur more commonly in older patients with therapy-related clonal hematopoiesis, mye...
Genomic determinants and differences of primary and secondary plasma cell leukemia
Abstract Introduction Plasma cell leukemia (PCL) is a rare, aggressive form of multiple myeloma (MM) defined by the presence of >5% c...
NRAS mutation drives excessive netosis and differentiation syndrome in acute promyelocytic leukemia
Abstract Background Acute promyelocytic leukemia (APL) is highly curable with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO). Howe...
Evolving annual community health worker time allocation to maximize sickle cell disease medical home efficiency
Abstract Background: Medical center-based Community Health Workers, also known as Patient Navigators (PNs), play a vital...
Microbiota metabolite phenlyacetylglycine alleviates acute graft-versus-host diseases
Abstract Introduction Acute graft-versus-host diseases (aGVHDs) is one of the most important complications after allogenic hematopoietic stem...
Risk assessment of myocarditis in patients undergoing chimeric antigen receptor T-cell therapy: A retrospective cohort analysis
Abstract Background: The advent of immunotherapy in oncology has increased the prevalence of immune-related adverse events. Chimeric Antigen...
Pre-clinical efficacy of FLT3/BRAF targeting with novel dual inhibitor PHI3 in FLT3/RAS co-mutated AML
Abstract Introduction: In AML with FLT3 mutations, FLT3 inhibitors are routinely used in combination with induction chemotherapy in fit pati...
LRP-1 regulates T cell proliferation and activation through global lipid network and loss of LRP-1 eliminates GVHD In Vivo
Abstract LRP-1, low-density lipoprotein receptor-related protein, is a member of the LDL receptor family with multi-faced functions in the i...
Droplet digital PCR improves measurable residual disease detection and predicts relapse in KMT2A-rearranged leukemia after allogeneic hematopoietic stem cell transplantation: A prospective study
Abstract Background: KMT2A-rearranged (KMT2A-r) leukemia represents a high-risk subtype marked by aggressive biology and high early relapse r...
Marstacimab prophylaxis in participants with Hemophilia A or B with inhibitors: Results from the Phase 3 BASIS trial
Abstract Background Marstacimab is a monoclonal antibody that inhibits tissue factor pathway inhibitor to enhance thrombin generation and re...
Raising pre-transfusion HbS levels from 30% to 50% does not increase ischemic stroke recurrence in sickle cell disease: Results from a long-term single-center study
Abstract Introduction: Exchange transfusion remains the only strategy for the secondary prevention of ischemic stroke in sickle cell disease...
Estimating the United States cure-adjusted prevalence of diffuse large B-cell lymphoma (DLBCL): An epidemiological model
Abstract Introduction: Prevalence reflects both how often a disease occurs and how long patients survive. In diffuse large B-cell lymphoma (...
Risk of cardiovascular disease-related mortality in hematologic malignancy patients: A population-level US retrospective cohort study, 1975-2022
Abstract Background: Cardiovascular disease (CVD) now ranks as a leading cause of non-cancer mortality among cancer patients (pts). However,...
Gut microbiota-related lithocholic acid alleviates cgvhd-induced bronchiolitis obliterans syndrome by suppressing CD4+ T cell TCR signaling without impairing the graft-versus-leukemia effect
Abstract Background: Bronchiolitis obliterans syndrome (BOS) is one of the most devastating outcomes of chronic graft-versus-host disease (c...
Megakaryocytes engage in emperipolesis with neutrophils and emperipolesis by the immune MK subset leads to efferocytosis and is exacerbated by CXCR1/2 activation in myelofibrosis
Abstract Megakaryocyte emperipolesis of neutrophils is increased in the bone marrow of myelofibrosis patients and leads to their death by pa...
Bleximenib or placebo in combination with standard induction and consolidation therapy followed by maintenance for the treatment of patients with newly diagnosed KMT2A-rearranged or NPM1-mutant Acute Myeloid Leukemia eligible for intensive chemotherapy: A double-blind Phase 3 study (HOVON 181 AML / AMLSG 37-25)
Abstract Background and Significance Newly diagnosed (ND) acute myeloid leukemia (AML) with KMT2A rearrangement (KMT2Ar) is associated with...
CD22-CAR T cell multiomic features linked to patient outcomes in CD19-CAR resistant large B cell lymphoma
Abstract Background: Approximately half of patients with relapsed/refractory large B cell lymphoma (R/R LBCL) experience disease progression...
Overcoming CAR T cell resistance in NPM1c and KMT2Ar AML through menin pathway inhibition
Abstract Background. Acute myeloid leukemia (AML) remains a clinical challenge due to high relapse rates and limited durable treatment optio...
Efficacy and safety profile of obecabtagene autoleucel as a CAR T-cell therapeutic agent
Abstract Introduction - Obecabtagene autoleucel, a novel chimeric antigen receptor (CAR) T-cell therapy aimed at CD19, is a revolutionary me...
Impact of the stromal microenvironment on the extrinsic apoptotic pathway in multiple myeloma
Abstract Introduction: Multiple myeloma (MM) is the second most common hematological malignancy. Advancements in therapy have resulted in a f...