Blood
Articles in this Issue
Dual pathways of antibody-dependent phagocytosis: Distinct kinetics, finite capacities, and therapeutic implications
Abstract Macrophage antibody dependent cellular phagocytosis (ADCP) is a major cytotoxic mechanism for therapeutic monoclonal antibodies (mA...
Mitoxantrone hydrochloride liposome (Lipo-MIT) combined with azacitidine and Chidamide can be an effective chemotherapy regimen for patients with angioimmunoblastic T-cell lymphoma (AITL)
Abstract Background: Angioimmunoblastic T-cell lymphoma (AITL) originates from follicular helper T-cell (THF), is the second most common subt...
Comparable outcomes of haploidentical, sibling, and unrelated donor transplantation for adult T-ALL in second remission: a study from the global committee and ALWP of the EBMT
Abstract Introduction T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive precursor lymphoid neoplasm that accounts for 20% to 25%...
Efficacy and safety of the polatuzumab, acalabrutinib, rituximab, and lenalidomide (Pola-AR2) regimen as first-line therapy in unfit or frail patients with diffuse large B-cell lymphoma
Abstract Background Elderly patients often present with multiple comorbidities due to age-related decline in physiological function, leading...
Regimen-stratified genomics identifies candidate markers of benefit and resistance in adult T-cell leukemia/lymphoma
Abstract Introduction. Adult T-cell leukemia/lymphoma (ATLL) is an aggressive, rare malignancy with poor survival despite anthracycline-base...
Allogeneic stem cell transplantation with post-transplantation cyclophosphamide in patients with acute myeloid leukemia achieving first complete remission after one versus two inductions: A study from the ALWP/EBMT
Abstract Background: Allogeneic transplantation (HSCT) is a curative therapeutic option for high-risk AML. The results of HSCT are in correl...
Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma
Abstract Introduction: Multiple myeloma (MM) remains incurable despite ongoing advancements in treatment, with the major...
Late re-expansion and high-level persistence of CAR T-cells can be driven by single CAR+ T-cell clones without clinically evident CAR+ T-cell lymphoma
Abstract Chimeric antigen receptor (CAR) T-cells have proven highly efficacious in the treatment of relapsed/refractory B-cell malignancies....
NSD2 expression remodels DNA methylation, creating a targetable epigenetic dependency in t(4;14) multiple myeloma
Abstract Introduction: The t(4;14) translocation subtype of multiple myeloma (MM) is characterized by overexpression of NSD2, a histone meth...
Neutrophil subpopulation-specific ratio and neutrophil extracellular traps are dynamic and sensitive biomarkers of thrombo-inflammation in patients with acute coronary syndrome – a prospective study
Abstract Neutrophils have recently emerged as important effectors of thrombo-inflammation that contribute to the initiation and progression...
First report of successful, lifesaving and timely graft rescue using an off-the-shelf cryopreserved, cadaveric marrow in myeloablative transplant with an unexpected unavailability of a living matched unrelated donor.
Abstract BACKGROUND: Allogeneic hematopoietic cell transplantation (alloHCT) remains a curative therapy for patients with acute myeloid leuk...
The total blood n-glycome landscape of hematological malignancies
Abstract Introduction Hematological malignancies (HM) are heterogeneous with complex pathophysiology. Glycans, the third major informational...
Alterations in the gut microbiome and the association of butyrate producers with progression-free survival in multiple myeloma patients undergoing autologous stem cell transplantation
Abstract Background: The gut microbiome and microbial metabolites are key predictors and modulators of tumorigenesis, anti-tumor immunity, a...
The use of danicopan as an add-on therapy in a ravulizumab-treated adult patient with paroxysmal nocturnal hemoglobinuria (PNH) and concomitant stage IV renal failure has induced a marked improvement of anemia and of clinically significant extravascular hemolysis in absence of deterioration of renal function
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired blood disorder characterized by chronic hemolytic anemia, thrombosis...
Persistent binding of DNMT1 to chromatin causes replication dysfunction in TP53-mutated myeloid neoplasms
Abstract Mutations in TP53 are the worst prognostic factor for myeloid malignancies, with a median survival of 6-9 months. Treatment with a...
Physical activity in patients undergoing hematopoietic stem cell transplantation
Abstract Background: Hematopoietic stem cell transplant (HSCT) recipients experience a high physical and emotional symptom burden that can i...
A randomized Phase II trial of ASTX727 and venetoclax with or without enasidenib for newly diagnosed older adults with IDH2 mutant Acute Myeloid Leukemia: A myelomatch substudy (MM1OA-S03)
Abstract Background: Acute myeloid leukemia (AML) with an IDH2 mutation represents a distinct molecular subtype with sensitivity to venetocla...
Final results from the embolden trial: pembrolizumab in combination with decitabine and pralatrexate in heavily pretreated patients with peripheral and cutaneous T-cell lymphoma
Abstract Background: Patients with relapsed or refractory (R/R) peripheral T-cell lymphoma (PTCL) have a poor prognosis with median overall...
Association between extreme heat exposures and survival in patients with multiple myeloma
Abstract Introduction Climate change has far-reaching health implications through a variety of exposure pathways, including heat stress from...
Real-world outcomes of sutimlimab in cold agglutinin disease: A multicenter trinetx analysis
Abstract Background Cold Agglutinin Disease (CAD) is a rare autoimmune hemolytic anemia, caused by cold agglutinins (IgM autoantibodies) tha...
Targeting NLRP3 with ofirnoflast, alone or in combination with semaglutide, ameliorates inflammatory anemia associated with obesity-induced inflammation in rodent models
Abstract Background: Inflammatory anemia is a common manifestation of chronic disease that arises when sustained cytokine-mediated inflammat...
The prognostic value for survival of frailty and patient-reported outcomes in relapsed/refractory multiple myeloma: Results from a prospective multicenter observational study
Abstract Background Clinical decisions for patients with relapsed/refractory multiple myeloma (RRMM) are challenging and assessment of frail...
Patient-reported outcomes and actigraphy following in-class transition (iCT) from parenteral bortezomib (V) to oral ixazomib in newly diagnosed multiple myeloma (NDMM): Subgroup analysis of US MM-6 by race/ethnicity, renal function, and area income
Abstract Introduction: Prolonged parenteral treatment for multiple myeloma may expose patients (pts) to cumulative side effects that can sign...
Incidence of venous thromboembolism in transgender individuals on estrogen-based gender-affirming hormone therapy
Abstract Background: Historically, the use of estrogen-based gender-affirming hormone therapy (E-GAHT) has been associat...
Hematopoietic stem cell transplantation in T-cell lymphomas: A promising strategy challenging poor prognosis
Abstract Introduction: T-cell lymphomas (TCLs) are a rare and aggressive entity, with a higher prevalence in Latin America and Asia. The mos...