Blood
Articles in this Issue
JAM(A), a chromosome 1q adhesion protein, is overexpressed in 1q amplified myeloma and may represent a novel therapeutic target for high-risk disease.
Abstract Background: Gain(1q) is among the most frequent high-risk cytogenetic abnormalities in multiple myeloma (MM), closely linked with t...
Early loss of platelet response and rehospitalization following high-dose dexamethasone in patients with newly diagnosed ITP
Abstract Background: High-dose dexamethasone (HD-DXM) and prednisone are both standard first-line treatments for newly diagnosed immune thro...
Comparing CHOP, R-CHOP, R-EPOCH, and DA-EPOCH-R in HIV-associated diffuse large B-cell lymphoma: A meta-analysis and systematic review
Abstract INTRODUCTION Diffuse Large B-Cell lymphoma (DLBCL) is the most common subtype of non-hodgkin lymphoma in patients with human immuno...
Efficacy and safety of inotuzumab ozogamicin combined with venetoclax and dexamethasone in relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL)
Abstract Background: Relapsed or refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) is associated with poor outcomes, with low compl...
Cardiovascular outcomes in CLL patients receiving GLP-1 agonists and BTK inhibitors: A global propensity-matched study
Abstract INTRODUCTION: Bruton tyrosine kinase inhibitors (BTKis) are becoming the preferred treatment for patients with chronic lymphocytic...
Srsf2P95H and Nf1 deficiency synergistically activate JAK-STAT signaling and exacerbate age-related clonal hematopoiesis in mice
Abstract Clonal hematopoiesis (CH) is an age-related condition characterized by clonal expansion of hematopoietic stem cells (HSCs) bearing...
Chromameter-measured skin lightness: A novel noninvasive marker for liver iron in thalassemia patients
Abstract Introduction: Liver iron concentration (LIC), measured by magnetic resonance imaging (MRI), remains the gold standard for assessing...
Impact of bridging therapies prior to CAR T cell therapy for large B-cell lymphoma: Real-world analysis from the cell therapy consortium
Abstract Introduction Treatment with anti-CD19 CAR T cell therapy for patients (pts) with relapsed/refractory (R/R) large B-cell lymphoma (L...
Real world evidence of treatment patterns in hereditary hemorrhagic telangiectasia
Abstract Hereditary hemorrhagic telangiectasia (HHT), is an inherited bleeding disorder characterized by recurrent epistaxis, mucocutaneous...
Real-world hemoglobin (Hb) outcomes of patients with lower-risk myelodysplastic syndromes (LR-MDS) receiving first-line (1L) luspatercept or 1L erythropoiesis-stimulating agents (ESAs) in the US
Abstract Background: More than 80% of patients with LR-MDS have anemia, which is associated with a higher risk of cardia...
Singe agent off-the-shelf CAR-NK (CD-19 t-haNK) cell therapy in combination with rituxumab Results in complete response in participants with waldenstrom's macroglobulinemia
Abstract Background: Relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (NHL), including incurable Waldenström's macroglobulinemia (WM...
Spectrum, molecular features, and clinical outcomes of hematologic malignancies and clonal hematopoiesis in li fraumeni syndrome
Abstract Background: Li Fraumeni syndrome (LFS) is a cancer predisposition syndrome caused by germline pathogenic varian...
Mitoxantrone liposome plus cytarabine and azacitidine for newly diagnosed Acute Myeloid Leukemia: A prospective, multicenter, randomized controlled study
Abstract Abstract introductionAcute myeloid leukemia (AML) is a genetically diverse type of blood cancer, making up around 70% of all acute...
Real-world discontinuation of cBTKi-based treatments in patients with CLL/SLL in the United States
Abstract Background With the evolution of the treatment (tx) landscape, covalent Bruton tyrosine kinase inhibitors (cBTKi) are one of the mo...
Association between pre-existing mental health history and higher risk of mental health outcomes post-CAR-t therapy in patients with hematologic malignancies
Abstract Background: Chimeric Antigen Receptor T-cell Therapy (CAR-T) has emerged as a revolutionary immunotherapy that utilizes genetically...
Identification of a development-restricted, megakaryocyte-primed population of hematopoietic progenitor cells during fetal and early postnatal development
Abstract During development, hematopoiesis unfolds in successive, partially overlapping waves. Primitive and pre-definitive progenitors aris...
Asciminib (ASC) in chronic myeloid leukemia in chronic Phase (CML-CP): Interim analysis (IA) efficacy and safety results of the Phase 2 ASC2ESCALATE trial in the cohort of newly diagnosed (1L) patients (pts)
Abstract Introduction ASC, a BCR::ABL1 inhibitor that inhibits kinase activity by specifically targeting the ABL myristoyl pocket, has previo...
Immune recovery and immunologic remodeling after CD19-directed chimeric antigen receptor T cell therapy in autoimmune diseases
Abstract Introduction Anti-CD19 Chimeric Antigen Receptor T cell therapy (CART19) is a promising treatment option for re...
Anti-leukemic efficacy of a novel inhibitor for KMT2A-r/FLT3-driven AML via multi-kinase targeting and synergy with menin inhibition
Abstract Introduction: Novel tyrosine kinase inhibitors (TKIs) are needed for combination therapy with menin inhibitors (menin-i) for KMT2A-...
Phase II Results of ECOG-ACRIN EA9152: A multicenter study of liposomal vincristine (L-VCR) or vincristine sulfate (VCR) and venetoclax (VEN) in relapsed or refractory acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL)
Abstract Background: Relapsed or refractory (R/R) acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL) rem...
Comparable PFS in isolated parenchymal cns vs systemic relapse of DLBCL: Results from a large real-world cohort
Abstract Introduction Despite therapeutic advances, a significant proportion of patients with diffuse large B-cell lymphoma (DLBCL) experienc...
Lessons from the IELSG45 trial: The impact of patient fitness on dropout rate in primary central nervous system lymphoma (PCNSL) studies
Abstract Background: Primary central nervous system lymphomas (PCNSL) are rare, aggressive B-cell malignancies with distinct biological and...
Disparities in access to CAR-T therapy in a Medicaid-predominant population: A Louisiana case study highlighting policy lag
Abstract Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized treatment for select hematologic malignancies. De...
Combination of genetics at baseline and clearance of MRD to assign the post-remission treatment of patients with Philadelphia-negative ACUTE lymphoblastic leukemia. FINAL results of pethema LAL19 trial
Abstract Introduction. Adults with Ph-negative acute lymphoblastic leukemia (Ph- ALL) may not require allogeneic hematopoietic stem cell tra...
A non-canonical glycolytic endpoint supports HSC survival and function
Abstract Glucose, the most abundant in vivo circulating nutrient, is essential for cell survival. Biochemistry textbooks posit glucose catab...