Blood
Articles in this Issue
Risk factors for progressive kidney impairment among patients with polycythemia vera (PV) are recapitulated and treatable in mouse models of PV
Abstract Background: PV is characterized by clonal hematopoiesis, thrombotic events, and potential progression to myelofibrosis (MF). The pr...
Impact of chemotherapy on survival in patients aged 75 years and older with Acute Myeloid Leukemia: A contemporary population-based analysis (2000–2022) from a national database
Abstract Background: Over the years, survival with chemotherapy has improved in older patients with acute myeloid leukemia (AML), but data r...
DARS mediated M2 polarization of tumor associated macrophages drives MPN progression
Abstract Chronic myeloproliferative neoplasms (MPNs) without the Philadelphia chromosome are clonal diseases of the bone marrow originating...
Impact of treatments with food restrictions on adherence and quality of life aspects among CML patients
Abstract Background In chronic myeloid leukemia (CML), Tasigna (nilotinib) and Scemblix (asciminib) are two current tyrosine kinase inhibito...
Real-world outcomes of elranatamab in relapsed/refreactor multiple myeloma: A single center analysis
Abstract Introduction: Elranatamab (Elra) is a BCMA-CD3 bispecific antibody (BsAb) approved for the treatment of relapsed and refractory mul...
Long-term follow-up for newly diagnosed BCR::ABL1 negative B cell acute lymphoblastic leukemia from China: 10-year outcome of RJ-ALL 2014 protocol
Abstract Introduction Pediatric inspired chemotherapy has been successfully applied in adult acute lymphoblastic leukemia (ALL). Short-term e...
DNA-proximal MYB phosphorylation is required for oncogenic transcription in acute myeloid leukemia
Abstract Dysregulation of gene expression is an essential feature of most human cancers, including acute myeloid leukemia (AML). Despite dis...
Dichotomy of TP53 mutant AML MRD microenvironment: Spatially segregated immunosuppressive mechanisms and niche-specific structural support
Abstract Despite recent advances in the treatment of acute myeloid leukemia (AML), most patients with AML relapse and succumb to the disease...
Unraveling the distinct biology of ATLL: Clinical and genetic divergence from other peripheral T-cell lymphomas
Abstract Background: Adult T-cell leukemia/lymphoma (ATLL) is a distinct entity of peripheral T-cell lymphoma (PTCL) associated with chronic...
Primary central nervous system lymphoma reveals a pro-tumoral brain-specific myeloid landscape.
Abstract Background: Primary Central Nervous System Lymphoma (PCNSL) ranks among the most aggressive MCD-ABC-DLBCLs driven by MYD88L265P and...
Detection of NPM1 mutation in Acute Myeloid Leukemia by multiple droplet digital PCR and its clinical application value
Abstract Multiple droplet digital PCR detection of measurable residual disease in NPM1 mutation in acute myeloid leukemia Objective The NPM1...
EZH2 and CREBBP mutation status identify a subset of patients who benefit from bendamustine- over CHOP/CVP-based immunochemotherapies in follicular lymphoma: Findings from the GALLIUM trial and validation in a large international cohort
Abstract Background: Follicular lymphoma (FL) remains a clinical challenge due to its relapsing course and difficulty in tailoring therapies...
Economic and clinical impact of emicizumab in people with moderate and severe Hemophilia A in the US
Abstract Introduction: Emicizumab is a recombinant, humanized, bispecific, monoclonal antibody that has become the standard of care in hemop...
Inhibition of PRMT5 with JNJ-64619178 sensitizes B-cell non-Hodgkin lymphoma cells to both intrinsic and extrinsic apoptosis
Abstract Introduction: Protein arginine methyltransferase 5 (PRMT5), a type II arginine methyltransferase, is overexpressed in several aggre...
Cost-effectiveness of heparin-induced thrombocytopenia (HIT) diagnostic strategies: Rapid PF4/heparin versus ELISA-based antibody testing strategies in the care of hospitalized people with suspected HIT
Abstract INTRODUCTION Patients with elevated 4Ts scores for suspected heparin-induced thrombocytopenia (HIT) require imm...
Patterns, risk factors and management of CD19-directed chimeric antigen receptor T-cell therapy failure in CNS lymphoma
Abstract Background: CD19-directed Chimeric Antigen Receptor T-cell therapy (CD19-CAR) is highly effective in recurrent CNS lymphomas (CNSL)...
Idiopathic neutropenia after clonal and antigenic exclusion: A progesterone-dependent subtype
Abstract Chronic idiopathic neutropenia (CIN) is characterized by a persistently reduced absolute neutrophil count, typically <1.5×10...
Autoimmune hemolytic anemia (AIHA) associated with human immunodeficiency virus (HIV) infection: Two challenging cases
Abstract Background: Patients with HIV often develop hematologic complications. While anemia is multifactorial, elevated direct antiglobulin...
Balancing risk and benefit: Fluoroquinolone prophylaxis in hyper-CVAD for acute lymphoblastic leukemia in a high fluoroquinolone-resistance setting
Abstract Background: Infectious complications are the leading cause of non-relapse mortality in adults with acute lymphoblastic leukemia (AL...
Blood group o and a lower endogenous thrombin potential are associated with increased risk for future bleeding after hemostatic challenges in bleeding disorder of unknown cause
Abstract Background. Bleeding disorder of unknown cause (BDUC) is diagnosed in patients who present with clinically significant bleeding sym...
Exploring the efficacy and safety of low-dose ATG combined with fractionated low-dose ptcy in preventing gvhd after allogeneic hematopoietic stem cell transplantation
Abstract Background In recent years, growing evidence has demonstrated the potential of anti-thymocyte globulin (ATG) combined with post-tra...
Updated efficacy and safety results of the Bruton tyrosine kinase (BTK) degrader BGB-16673 in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) from the ongoing phase 1 CaDAnCe-101 study
Abstract Introduction: BTK inhibitors are effective treatments for CLL/SLL; however, treatment intolerance and resistance to BTK inhibitors...
Development of a prediction model for maternal pregnancy complications in sickle cell disease
Abstract Introduction Pregnant individuals with sickle cell disease (SCD) face dramatically increased maternal risks, with prior work showin...
Concurrent clonality of multiple hematopoietic lineages: Implications for pathogenesis and management of cytopenia
Abstract Blood cells with clonal abnormalities linked with neoplasia have been observed in not only otherwise healthy individuals, but also...
Comorbid COPD as a major independent predictor of post-discharge morbidity in adults hospitalized for sickle cell acute chest syndrome: A national propensity-matched analysis
Abstract Introduction Patients with sickle cell disease (SCD) experience a state of endothelial dysfunction and hypercoagulability, which el...