Blood
Articles in this Issue
Effiefficacy and safety of allogeneic CD123 CAR-NK cell therapy in Relapsed/Refractory Acute Myeloid Leukemia
Abstract Background: While CAR-T cell therapy has revolutionized the treatment of certain hematologic malignancies, including B-cell maligna...
Identifying barriers to clinical trial enrollment for children with relapsed or refractory hematologic malignancies
Abstract Introduction: Outcomes for children with de novo hematologic malignancies have improved significantly over the past 50 years. Howev...
Beyond presence: Clinical relevance of FLT3-ITD length and location in Acute Myeloid Leukemia (AML)
Abstract Acute Myeloid Leukemia (AML) is a heterogeneous hematologic malignancy characterized by multiple genetic abnormalities. The Interna...
Evaluation of ims-IP assay for the detection and typing of monoclonal immunoglobulins by mass spectrometry.
Abstract Background: Serum and urine protein electrophoresis have long served as the mainstay for monitoring monoclonal protein (M-protein)...
The clot thickens: Diagnosing APS in the setting of multifocal thrombosis
Abstract Introduction Embolic stroke in young patients without traditional risk factors requires a broad differential, i...
A subset of myeloid progenitors drives leukemogenesis in familial CEBPA-mutated acute myeloid leukaemia
Abstract CEBPA is a transcription factor mutated in 10-15% of Acute Myeloid Leukemia (AML), including in families with germline mutations, p...
Efficacy of maintenance therapy after auto-HSCT in patients with multiple myeloma (MM) in sustained minimal residual disease (MRD) negativity remission
Abstract Introduction: International recommendations are based on the absolute necessity of prescribing maintenance therapy (MT) after auto-...
Anticoagulation management and outcomes in cancer-associated ovarian and renal vein thrombosis: A multicenter retrospective cohort study
Abstract Background: Ovarian and renal vein thromboses (OVT, RVT) are rare in the general population but occur more frequently in patients w...
Updates of R/R CLL with prior exposure to Bruton's tyrosine kinase (BTK) inhibitor and/or bcl-2 inhibitor in the Phase 1 trial of LP-168 (Rocbrutinib), a novel COVALENT and non-COVALENT BTK inhibitor
Abstract Introduction: LP-168 (rocbrutinib) is a new selective next-generation inhibitor of BTK that broadly targets wild-type (WT) BTK irre...
The recurrent AML-associated CBFBD87GDSY mutation has hypomorphic function and is mechanistically distinct from CBFB:MYH11
Abstract Core Binding Factor (CBF) is a heterodimeric transcription factor composed of one alpha subunit (predominantly RUNX1 in hematopoiet...
Default one-stage assay for hospitalized hemophilia A patients: A cautionary tale
Abstract Case Presentation: A 22-year-old male with past medical history significant for mild hemophilia A (1820 G&g...
Efficacy and safety of CPX-351 in high-risk Acute Myeloid Leukemia
Abstract Introduction: CPX-351 is a dual liposomal drug (daunorubicin and cytarabine) approved for the treatment of high...
Functional characterization of a novel germline JAK2 R989fs mutation
Abstract Janus kinase 2 (JAK2) mutations are key drivers of Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), with somat...
A retrospective quality improvement review of cryoprecipitate overuse in a community hospital
Abstract Background: Cryoprecipitate is indicated for bleeding patients with hypofibrinogenemia, typically when fibrinogen levels fall below...
Willingness to pay for DLBCL treatment characteristics in Japan
Abstract Introduction:Treatment decision-making in relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) is increasingly complex, es...
The impact of distance to CAR-T centre on CAR-T delivery and CAR-T outcomes: A single centre retrospective cohort study
Abstract Background: Chimeric Antigen Receptor T-cell (CAR-T) therapy has transformed the treatment landscape for relapsed and refractory B-...
RNF20 promotes the progression of diffuse large B-cell lymphoma through regulating ubiquitination-dependent Phase separation of fus
Abstract RNF20 is an E3 ubiquitin ligase known to regulate transcription, DNA repair, and chromatin architecture. Emerging evidence has foun...
Early allogeneic stem cell transplantation enhanced survival of co-expressed NUP98::NSD1 and FLT3-ITD Acute Myeloid Leukemia: An exploratory analysis.
Abstract Introduction: NUP98::NSD1, a frequent aberration in acute myeloid leukemia (AML) with NUP98 rearrangements, is characterized by poo...
Bexobrutideg (NX-5948), a novel Bruton's tyrosine kinase (BTK) degrader, demonstrates rapid and durable clinical responses in Relapsed/Refractory chronic lymphocytic leukemia (CLL): New and updated findings from an ongoing Phase 1a/b trial
Abstract Introduction: Although BTK inhibition has proven to be a successful treatment modality in CLL, the emergence of BTK inhibitor (BTKi...
Impact of primary CNS prophylaxis in high CNS-IPI DLBCL: Analysis from the czech national lymphoma registry
Abstract Background: Central nervous system (CNS) progression/relapse of diffuse large B-cell lymphoma (DLBCL) is a rare but fatal event. As...
Increased age-adjusted mortality rates from hemophagocytic lymphohistiocytosis (HLH), 2010-2023
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome leading to multiorgan failu...
Construction of mindfulness based cancer rehabilitation training program for malignant hematology patients based on the Liverpool mindfulness model
Abstract Background: As one of the top ten malignancies in China with high morbidity and mortality rates, hematologic malignancies expose pa...
Every step counts: Quantifying VTE risk across various mobility levels in the hospital setting
Abstract Background Hospital-acquired venous thromboembolism (VTE) is a major cause of morbidity and mortality, but thromboprophylaxis can l...
Efficacy and safety of RCD pulse regimen for acquired Hemophilia A
Abstract Background: Acquired hemophilia A (AHA) is a rare bleeding disorder in which inhibitory antibodies neutralize f...
Reduction in corticosteroid use with rilzabrutinib and sustained response in adults with persistent/chronic immune thrombocytopenia in the long-term extension period of the Phase 3 LUNA3 study
Abstract Introduction Immune thrombocytopenia (ITP) is characterized by immune dysregulation leading to platelet destruction and impaired pl...