Blood
Articles in this Issue
Correlation between outpatient opioid dosage and hospital visits in sickle cell disease patients
Abstract Introduction Sickle Cell Disease (SCD) is an autosomal recessive blood disorder caused by defective hemoglobin that leads to the “s...
Vitamin B6 deficiency: A cause of unexplained anemia in hospitalized patients in a tertiary care center
Abstract Introduction: Anemia is a frequent clinical problem in hospitalized patients. While iron, vitamin B12, and folate deficiencies are...
Spatial biomarkers of CAR-T treatment response in relapsed refractory multiple myeloma
Abstract Autologous chimeric antigen receptor (CAR) T-cell therapy has shown promise for relapsed/refractory multiple myeloma (MM), but dise...
Blinatumomab before and after allogeneic hematopoietic stem cell transplantation in adult patients with B-cell acute lymphoblastic leukemia
Abstract Background: Allogeneic hematopoietic stem cell transplantation (AHSCT) plays a crucial role in the curative strategy for acute B-ce...
The improvement of renal function by complement inhibitors in patients with paroxysmal nocturnal hemoglobinuria
Abstract Background:Patients with paroxysmal nocturnal hemoglobinuria (PNH) experience chronic intravascular hemolysis due to the deficiency...
The bromodomain and extra-terminal domain protein BRD4 promotes both self renewal and inflammation in TET2 mutated clonal hematopoiesis
Abstract Progression of clonal hematopoiesis (CH) to myeloid neoplasms (MN) is highly dependent upon inflammatory signaling. The epigenetic...
Zilovertamab vedotin plus R-CHP versus polatuzumab vedotin plus R-CHP as first-line therapy in participants with germinal center B-cell diffuse large B-cell lymphoma (DLBCL): The randomized, open-label, Phase 2 waveline-011 Study
Abstract Introduction: DLBCL is a genetically heterogeneous malignancy that can be broadly categorized into 3 subtypes: activated B-cell–lik...
MO-TRANS update: A randomized, double-blind, placebo-controlled, multi-center phase III study of mocravimod (MOC) as maintenance treatment in AML patients undergoing allogeneic hematopoietic cell transplantation
Abstract Background Allogeneic hematopoietic cell transplantation (allo-HCT) is an increasingly important curative option in adults with hig...
Molecular subtypes and BH3 mimetic synergy with anti-leukemia agents in T-cell acute lymphoblastic leukemia
Abstract Compared to B-cell acute lymphoblastic leukemia (ALL), treatment outcomes of T-ALL remain inferior, especially in relapsed or refra...
A retrospective analysis of fever incidence following vincristine administration in pediatric oncology patients
Abstract Background:Vincristine (VCR) is a commonly utilized chemotherapy agent for the treatment of pediatric cancers including leukemia, l...
The effect of bezuclastinib on the pathobiology of mastocytosis: Changes in BM mast cells, tryptase, and KIT p.D816V variant allele frequency from the pivotal summit trial
Abstract Background: Systemic mastocytosis (SM) includes a spectrum of hematologic malignancies characterized by a variable degree of neopla...
Activated factor IX Ρadua delivered via adeno-associated virus enhances therapeutic efficacy in hemophilia B
Abstract Hemophilia B is a recessive X-linked bleeding disorder caused by a deficiency of coagulation factor IX (FIX), leading to trauma-ind...
Reproductive health care in a post-dobbs landscape for people with sickle cell disease: Clinical practices and challenges from hematologist perspectives
Abstract Introduction: The hematology community has recognized the potential impact of the 2022 Dobbs v. Jackson Women's...
Translational investigation of tolinapant (ASTX660) in Acute Myeloid Leukemia using integrated clinical, bioinformatic, and pharmacological approaches
Abstract Tolinapant (ASTX660) is an antagonist of the inhibitor of apoptosis proteins (IAPs) cIAP1 (BIRC2), cIAP2 (BIRC3), and XIAP. These I...
Cell cycle dependent and independent regulation of AKT activity in germinal center B-cell-like diffuse large B-cell lymphoma – a dual role of cyclin dependent kinase 2
Abstract Introduction. The PI3K/AKT (phosphatidylinositol 3-kinase / protein kinase B) pathway is one of the most frequently mutated and dere...
Acalabrutinib plus venetoclax and rituximab in patients with treatment-naive (TN) mantle cell lymphoma (MCL): Results from the Phase 2 TrAVeRse study
Abstract Introduction: MCL is a rare B-cell non-Hodgkin lymphoma typically treated with first-line (1L) chemoimmunotherapy (CIT). While Brut...
Sex-and-ethnicity-related differences in primary central nervous system lymphoma based on the SEER database
Abstract BACKGROUND Primary central nervous system lymphoma (PCNSL) is a rare and aggressive form of Non-Hodgkin Lymphoma. Typically, PCNSL a...
The effect of recombinant factor VIIa treatment in non-traumatic intracranial hemorrhage: Systematic review and meta-analysis
Abstract Background: Intracerebral haemorrhage (ICH) is a devastating condition that can be life-threatening and can result in substantial f...
Outcomes of older or unfit AML patients admitted to intensive care unit in the venetoclax era
Abstract Background Venetoclax (VEN) has transformed the management of patients (pts) with acute myeloid leukemia (AML)...
Endemic infections following CAR19-T-cell therapy: Real-life evidence in single-center in Brazil
Abstract Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy is a promising treatment for refractory hematologic malignancies, bu...
Long-term immune reconstitution and final 1-year follow-up after fixed-duration venetoclax-obinutuzumab (VenO) in first-line (1L) chronic lymphocytic leukemia (CLL): Results from the Phase III CRISTALLO trial
Abstract Background: Venetoclax + an anti-CD20 antibody has shown deep remissions and long-term immune recovery in patients (pts) with relap...
GWAS-guided pharmacogenomic risk scores predict premedication-related pegaspargase hypersensitivity and toxicities in pediatric and adolescent young adults with acute lymphoblastic leukemia or lymphoma
Abstract Background: The addition of asparaginase to chemotherapy regimens has played a key role in significantly improving outcomes in pedi...
Vitamin B12 drives epigenetic reprogramming and leukemia progression through metabolic rewiring in AML
Abstract Introduction: Large population studies have shown that elevated vitamin B12 serum levels are associated with increased all-cause mo...
Arterial thrombotic events in lymphoma patients: Systematic review and meta-analysis
Abstract Introduction: Arterial thrombotic events (ATE) represent a serious but underreported complication in lymphoma patients, potentially...
Emicizumab for severe von willebrand disease (VWD): The (EmiVWD) study enrollment 2025
Abstract Background and Significance: Von Willebrand Disease (VWD) is the most common inherited bleeding disorder affecting up to 0.1-1% of...