Blood
Articles in this Issue
A long-term antigen-spreading by novel cancer vaccine with hyaluronic acid nanogel accelerate the anti-neoplastic efficacy of cytotoxicity of infused TCR-T cells and altered neplastic microenvironment
Abstract Background Recent progress of engineered T cells genetically modified to express tumor-specific T-cell receptors (TCR-T) has demons...
Tolerability and long-term survival of fragile or older patients with diffuse large B cell lymphoma (DLBCL) not otherwise specified by R-CDOP
Abstract Introduction: According to Surveillance, Epidemiology, and End Results data, Diffuse Large B-Cell Lymphoma (DLBCL) is diagnosed at...
Collaborative outreach and education for management of bi-specific antibody treatment side effects in Relapsed/Refractory multiple myeloma (COMBAT-RRMM)
Abstract Introduction: Bi-specific antibodies (BsAbs) have emerged as a pivotal therapy for in relapsed or refractory di...
Single cell spatial transcriptomics reveals age-dependent cellular organization of mouse bone marrow
Abstract Hematopoiesis occurs in the complex microenvironment of the bone marrow. This includes interactions between hematopoietic cells the...
Real-world efficacy and safety of ixazomib maintenance therapy in Chinese patients with newly diagnosed multiple myeloma: A multicenter retrospective study
Abstract Background: Maintenance therapy plays a critical role to prolong remission and improve outcomes in multiple myeloma (MM). Ixazomib...
Point of care anti-CD19 CAR-T for autoimmune diseases
Abstract Introduction: Anti-CD19 CAR-T cell therapy has revolutionized the treatment of B-cell malignancies. Given the c...
Developing transcriptomic signature for IDH1 and IDH2 acute leukemia and the demonstration of high prevalence of these signatures in mutation-negative leukemia
Abstract Introduction: Despite multiple studies, the impact of IDH1 and IDH2 (IDH1/2) mutations on the overall biology and clinical outcome...
A tandem CD19/ROR1 CAR-NK to overcome Wnt5a-mediated apoptotic resistance in chronic lymphocytic leukemia
Abstract Introduction While autologous CD19-directed CAR-T cell therapy has been highly efficacious in certain B cell malignancies, its effi...
Availability of blood products and transfusion practices in sub-saharan Africa for the management of patients with sickle cell disease: A survey in 16 countries.
Abstract Background: Red blood cell (RBC) transfusions play a critical role in managing severe acute complications in patients with sickle c...
First report of novel biallelic KLF1 variants causing prenatal onset severe transfusion-dependent non-spherocytic hemolytic anemia in North America
Abstract Kruppel-like factor 1 (KLF1) is an essential erythroid transcription factor that regulates globin gene switching and red blood cell...
Preliminary immunophenotyping in acquired Hemophilia A reveals an imbalanced immune activation landscape
Abstract Acquired hemophilia A (AHA) is a rare autoimmune disease characterized by the development of autoantibodies against the factor (F)V...
Phase 1 clinical trial of point-of-care manufactured, fully human anti-CD19 CAR-T cells for treatment of Relapsed/Refractory lymphoid malignancies
Abstract Background: Chimeric antigen receptor (CAR) T cells have revolutionized care for lymphoid malignancies but continue to present chal...
Recent trends in the management of relapsing/refractory diffuse large B-cell lymphoma: A systematic review of the literature
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive non-Hodgkin lymphoma, known for its invasive natu...
Disparities and trends in hospice facility deaths among leukemia patients
Abstract Background Patients with advanced or refractory hematologic malignancies experience a distinct disease course w...
Detecting lineage-specific regulatory activity and stemness retention in single-cell multiomics of human hematopoiesis
Abstract Introduction: The prevalence of epigenetic regulator mutations in clonal hematopoiesis and hematologic malignancies highlights the...
Prognosis of FLT3 ligand level in newly diagnosed FLT3-ITD negative Acute Myeloid Leukemia patients enrolled in the pethema QUIWI trial
Abstract Introduction FMS-like tyrosine kinase 3 (FLT3) plays a critical role in hematopoiesis. Circulating levels of its ligand, the solubl...
Myeloproliferative neoplasm thrombosis risk characterized by MerTK biomarker
Abstract Introduction Thrombosis remains a major cause of morbidity and mortality in patients with myeloproliferative neoplasms (MPN). Identi...
G-CSF receptor is a signaling node linking thrombo-inflammation to vaso-occlusion in sickle cell disease: Target for a new phase 2 trial
Abstract Introduction Granulocyte-colony stimulating factor (G-CSF) administration is known to induce severe vaso-occlusive crisis (VOC) in...
Novel PF4/heparin complexes drive platelet activation in heparin-induced thrombocytopenia
Abstract Understanding the interaction between platelet factor 4 (PF4) and heparin is essential for elucidating the pathogenesis of heparin-...
Optimizing multiple myeloma assessment for newly diagnosed patients across a large, 33 hospital healthcare system: A mixed methods analysis
Abstract Introduction Only 20-50% of patients with multiple myeloma (MM) who are transplant eligible (TE) undergo autologous stem cell trans...
A novel CD20-conjugated γδ T cell therapy via unnatural sugar-mediated chemical modification for the treatment of EBV-PTLD
Abstract Background: Epstein-Barr virus (EBV)-associated post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complicat...
Effects of race, sex, marital status, and urban/rural setting on survival in patients with acute myeloid leukemia
Abstract Background: Demographic factors such as race, sex, marital status, and rural-urban setting have been shown to b...
Impairing NAD+ synthesis is a powerful tool to increase the efficacy of the BTK inhibitor ibrutinib in Waldenström's macroglobulinemia.
Abstract Waldenström's Macroglobulinemia (WM) is a rare indolent B-cell lymphoma characterized by the infiltration of bone marrow with lymph...
Disease stage-specific mutational landscape in essential thrombocythemia and prognostic correlates: A Mayo Clinic study of 500 NGS-informative cases
Abstract Background In our first exploration of mutations in essential thrombocythemia (ET; N=183), we described somatic variants other than...
TP53 inactivation confers resistance to the menin inhibitor revumenib in Acute Myeloid Leukemia
Abstract Acute myeloid leukemia (AML) is a heterogeneous and aggressive hematologic malignancy associated with poor outcomes and limited tre...