Blood
Articles in this Issue
Dual complement and P-selectin inhibitor, IHP-102, prevents lung vaso-occlusion in P-selectin-deficient townes SS mice
Abstract Background Sickle cell disease (SCD) is the most common monogenic blood disorder that is widely recognized for its hallmark vaso-oc...
Nationwide impact of CAR-T approval on acute lymphoblastic leukemia mortality in the United States, 1999-2023: Difference-in-differences and synthetic control analyses
Abstract Background Anti-CD19 chimeric antigen receptor T-cell (CAR-T) therapy received its first U.S. approval for rela...
Incidence and risk factors of Epstein–Barr virus reactivation and post-transplant lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation: A 985-patient retrospective cohort analysis
Abstract Background: Epstein-Barr Virus (EBV) reactivation frequently occurs following allogenic stem cell transplantation (allo-HSCT). In a...
Hnrnpk haploinsufficiency in del(9q) Acute Myeloid Leukemia reveals targetable vulnerabilities
Abstract Deletion of the long arm of chromosome 9, del(9q), is a recurrent cytogenetic abnormality in AML and encompasses the HNRNPK locus a...
Real-world patient characteristics, treatment patterns, and outcomes among relapsed/refractory multiple myeloma patients receiving talquetamab-tgvs
Abstract Introduction Multiple myeloma (MM), the second most common hematologic cancer, is estimated to have 36,110 new United States (US) c...
Estimated cardiac deaths associated with treating chronic lymphocytic leukemia with ibrutinib versus zanubrutinib in the United States
Abstract Introduction Efficacy of the Bruton tyrosine kinase inhibitors zanubrutinib and ibrutinib as first-line (1L) tr...
Pre-diagnostic biomarkers show disease susceptibility continuum and enable early prediction of multiple myeloma
Abstract Background At diagnosis, multiple myeloma (MM) typically presents with a constellation of clinical features, including anemia, rena...
A Phase 2 study of sequential administration of gilteritinib after MEC chemotherapy in Relapsed/Refractory FLT3-mutated Acute Myeloid Leukemia in adults: Japan adult leukemia study group (JALSG) RR-FLT3-AML220 study
Abstract Introduction: The prognosis of newly diagnosed FLT3-mutated adult acute myeloid leukemia (AML) has recently improved by the combina...
Teriflunomide, an oral dihydroorotate dehydrogenase inhibitor, in immune thrombocytopenia
Abstract IntroductionPrimary immune thrombocytopenia (ITP) is an autoimmune disease, posing a serious threat to human health as one of the m...
BCL-2 inhibitor TQB3909 combined with JAK inhibitors in patients with intermediate- or high-risk myelofibrosis: A two-cohort, open-label, Phase ib/II, multicenter study
Abstract Introduction: Overexpression of anti-apoptotic proteins BCL-2 and BCL-XL has been observed in tumor cells of myelofibrosis (MF) pat...
primary thromboprophylaxis using direct oral anti-coagulants (DOAC) in malignant pediatric tumors with vascular compression
Abstract INTRODUCTION Cancer-associated thrombosis (CAT) is a recognized complication of pediatric malignancies. Vascular compression increas...
Diagnostic spectrum of CD5-positive, CD23-negative B-cell lymphoproliferative disorders: Analysis of a two-year patient cohort
Abstract Introduction: Chronic B-cell lymphoproliferative disorders (B-CLPDs) comprise a heterogeneous group of malignancies involving the c...
IRF2BP2 mutations activate IL-1β-mediated NF-κB signaling and confer actionable anti-IL-1β sensitivity in DLBCL
Abstract Diffuse large B cell lymphoma (DLBCL) is the most prevalent lymphoid malignancy in adults and exhibits significant heterogeneity. H...
Independent assessment of ALC thresholds currently in use to predict motor/neurocognitive toxicities (MNTs) after treatment with ciltacabtagene autoleucel
Abstract Background: Ciltacabtagene autoleucel (cilta-cel) achieves high rates of durable responses in multiple myeloma (MM) but has been as...
Cardiac safety of revumenib in children with HOX-driven leukemia: A single-institution cohort
Abstract Background Children with HOX-driven acute leukemias, including KMT2A and NUP98 rearrangements (r), have dismal outcomes after relap...
Ziftomenib in combination with venetoclax and azacitidine in newly diagnosed NPM1-m acute myeloid leukemia: Phase 1b results from KOMET-007
Abstract Introduction: Nucleophosmin 1 mutations (NPM1-m) drive leukemogenesis in approximately 30% of acute myeloid leukemia (AML) cases. Z...
PIM2-dependent modulation of mitochondrial mass and function in multiple myeloma
Abstract Multiple myeloma (MM) is a uncurable hematological malignancy of bone marrow resident plasma cells. The primary cause of treatment...
Impact of donor age on transplant outcomes in unrelated allogeneic hematopoietic stem cell transplantation using post-transplant cyclophosphamide-based gvhd prophylaxis
Abstract Background: Donor age is a recognized factor influencing outcomes after allogeneic hematopoietic cell transplantation (allo-HCT), w...
Relationship between changes in quality of life and social function and treatment response in patients with idiopathic multicentric castleman disease: A single-center observational longitudinal survey
Abstract The majority of multicentric Castleman disease (MCD) patients in China are idiopathic MCD (iMCD) with systemic manifestations. The...
Patient-driven insights in sickle cell disease: Results from a global survey informing public health strategies
Abstract Introduction An effective public health strategy aimed at improving outcomes in Sickle Cell Disease (SCD) must...
Surface protein-focused gene expression analysis identifies prognostic immunophenotypes in newly diagnosed multiple myeloma
Abstract Introduction Surface proteins in cancer not only reflect tumor–microenvironment interactions but also serve as targets for diagnost...
The impact of a clinical trial communication training workshop on hematology-oncology Fellows' knowledge, attitudes and behaviors: A mixed-methods evaluation
Abstract Introduction: Cancer clinical trials (CCTs) are essential to advancing the treatment of blood cancers and providing access to high-...
Single-unit cord blood transplantation reduces the risk of relapse and improves leukemia-free survival compared to other donor sources in allo-HSCT for patients with high-risk acute myeloid leukemia
Abstract Background: Outcomes of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with high-risk acute myeloid leu...
Impact of prognostic mutations on outcomes with fixed-duration acalabrutinib-venetoclax combinations versus chemoimmunotherapy: An exploratory analysis from AMPLIFY
Abstract Introduction: The AMPLIFY trial evaluated fixed-duration acalabrutinib + venetoclax ± obinutuzumab (AV/AVO) vs chemoimmunotherapy (C...
PET/CT parameters as predictors of early progression risk in newly diagnosed multiple myeloma patients eligible for autologous stem cell transplantation
Abstract Introduction In recent years, the treatment of multiple myeloma (MM) has undergone substantial evolution, resulting in improved ove...