Blood
Articles in this Issue
PTEN loss reprograms lipid metabolism to modulate venetoclax resistance in acute myeloid leukemia
Abstract Acute myeloid leukemia (AML) is an aggressive and biologically heterogeneous hematologic malignancy. It is characterized by the clo...
Treatment of type 1 plasminogen deficiency in women and girls with reproductive tract lesions: Pharmacokinetics and clinical outcomes with plasminogen therapy
Abstract Background: Type 1 plasminogen deficiency (PLGD-1) is an ultra-rare autosomal recessive disorder affecting approximately 1.6 indivi...
CAR-T cells targeting CD79b and CD19 exhibit robust antitumour activity against B cell lymphoma
Abstract Objective CD19-directed chimeric antigen receptor (CAR) T cells have yielded impressive response rates in refractory/relapse B-cell...
Epidemiology of cancer-associated venous thromboembolism in a nationwide electronic healthrecord database
Abstract Background Prior cancer-associated thrombosis (CAT) epidemiological studies focused on specific populations or single healthcare sy...
Risk factors for relapse and post-relapse outcomes in patients with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia receiving frontline blinatumomab-based regimens
Abstract Introduction: Blinatumomab (Blina) is a CD19/CD3 bispecific T-cell engager with demonstrated efficacy in B-cell acute lymphoblastic...
Real-world safety and effectiveness of hetrombopag in patients with primary immune thrombocytopenia
Abstract Introduction: Primary Immune Thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder characterized by isolated thrombocy...
Spatial asymmetry of blasts in bone marrow after hematopoietic stem cell transplantation for AML/MDS
Abstract Background Bone marrow (BM) aspiration is essential for monitoring post-transplant relapse in AML/MDS and is typically performed un...
Acute Myeloid Leukemia patients with comorbid hidradenitis suppurativa maintain stable disease during induction therapy–induced neutropenia: A single-center retrospective study
Abstract Background: Induction therapy for acute myeloid leukemia (AML) is associated with profound neutropenia, which can predispose patien...
A low-cost Clinical Prediction model for identifying female hemophilia carriers and women and girls with hemophilia (WGH) in central China
Abstract Background While hemophilia is traditionally considered an X-linked recessive disorder mainly affecting males, female hemophilia ca...
Identification of factors associated with a high success rate of treatment-free remission in chronic myeloid leukemia: A multicenter study in Taiwan
Abstract Background and purpose: Treatment-free remission (TFR) has become a goal for chronic myeloid leukemia (CML) patients treated with ty...
Real-world step-up dosing of patients receiving elranatamab for multiple myeloma in Japan
Abstract Background Elranatamab is the first bispecific B-cell maturation antigen (BCMA)-CD3–directed monoclonal antibody approved in Japan...
Afatinib boosts CAR-T cell antitumor therapeutic efficacy via metabolism and fate reprogramming
Abstract Background: Chimeric antigen receptor T (CAR-T) cell therapy has been shown remarkable efficacy in the treatment of hematological m...
Effectiveness and safety of CPX-351 in younger patients <60 years with newly diagnosed secondary Acute Myeloid Leukemia: Pooled analysis of US (V-RULES) and UK (CREST-UK) real-world studies
Abstract CPX-351 is a therapy approved for newly diagnosed (ND) therapy-related acute myeloid leukemia (t-AML) or AML with myelodysplasia-re...
A multicenter, single-arm study of camrelizumab combined with rituximab followed by R-CHOP as first-line treatment for young patients with primary extranodal diffuse large B-cell lymphoma: The credit trial
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is the most prevalent aggressive subtype of non-Hodgkin lymphoma, characterized by...
Standardizing lines of treatment (LOT) in multiple myeloma: Real-world validation of an automated rule-based algorithm
Abstract Background Accurate reconstruction of electronic health record (EHR) treatment sequences is essential for leveraging real-world dat...
Unlocking new frontiers in leukemia diagnostics through large language Model–Driven report generation
Abstract Background: Writing of diagnostic reports is a cumbersome and challenging task. Expert knowledge and cross-methodological thinking...
Dose and BTK occupancy relationship in the prospective Phase 2 TAILOR study: Exploratory end point analysis of the ibrutinib monotherapy cohorts in patients with previously untreated chronic lymphocytic leukemia
Abstract Introduction Continuous treatment with a Bruton's tyrosine kinase inhibitor (BTKi) is a standard of care option for patients (pts) w...
Assessment of coagulation potential of concomitant factor VIII administration in patients with haemophilia a receiving emicizumab prophylaxis (CAGUYAMA Study): A multicenter, open-label, non-randomized clinical trial
Abstract Introduction Emicizumab prophylaxis reduces bleeding in people with hemophilia A (PwHA), offering hemostatic activity equivalent to...
Thiotepa and busulfan combined with cyclophosphamide conditioning regimen plus maintenance therapy improved the disease-free survival of patients with relapsed/refractory haematologic malignancies after undergoing allogeneic transplantation
Abstract Objective: Conditioning regimens are critical for patients with relapsed/refractory (R/R) malignant haematologic diseases. Thiotepa...
AI-assisted diagnosis of paroxysmal nocturnal hemoglobinuria
Abstract Background: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by complement-mediated intravasc...
Platelet proteomic signatures reveal neurodegenerative and mitochondrial pathways associated with pain phenotypes in sickle cell disease
Abstract Background: Sickle cell disease (SCD) is a complex hematologic disorder marked by chronic pain and neurocognitive impairments. Whil...
Implementation of a next generation sequencing painel for lymphoid malignancies in Brazil: First report of molecular features in a low-middle income country
Abstract Background: The understanding of chronic lymphoproliferative disease has advanced significantly with the incorporation of next-gene...
Targeting early immunologic decline in acquired hemophilia A: A case for prophylactic rituximab
Abstract Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder caused by autoantibodies against factor VIII (FVIII). While immu...
Diagnosing mycosis fungoides using AI powered histologic analysis
Abstract Background Mycosis Fungoides (MF) is the most common type of cutaneous T-cell lymphoma. Unfortunately, the diagnosis of MF is chall...
A prospective, single-center, single-arm clinical trial of zanubrutinib monotherapy and zfcg combined therapy was given sequentially for the treatment of primary symptomatic CLL/SLL (Stop Trial)
Abstract Background: Although Bruton tyrosine kinase (BTK) inhibitor monotherapy yields an overall response rate (ORR) of 80–90% and prolong...