Blood
Articles in this Issue
Immunophenotypic identification of ETP-like T-ALL using CD1a, CD165 and CD184.
Abstract The early thymic precursor (ETP) immunophenotype identified by flow cytometry has defined a high-risk subset of T Lymphoblastic Leu...
Comparison of infections in patients with chronic lymphocytic leukemia (CLL) treated with BTKi versus venetoclax obinutuzumab in first line therapy
Abstract INTRODUCTION Chronic lymphocytic leukemia (CLL) is a lymphoid neoplasm with increased number of mature but immunologically dysfuncti...
IL18-armored CAR T cells in patients with CLL/SLL and Richter's transformation after prior BTK inhibitor and venetoclax failure
Abstract Background: The rate of complete remission (CR) in the pivotal trial that led to FDA approval of lisocabtagene maraleucel (liso-cel...
Updated real-world outcomes with brentuximab vedotin in lymphoma patients: A multicenter, retrospective study from China
Abstract Introduction: Brentuximab vedotin (BV) was first approved in China in 2020 for the treatment of patients with CD30-positive lymphom...
Clinical characteristics and treatment patterns of elderly patients living with Mantle Cell Lymphoma
Abstract Background: Mantle Cell Lymphoma (MCL) is an incurable subtype of non-Hodgkin lymphoma with a median age of 68 yrs at diagnosis. Wh...
Extended duration anticoagulation in cancer associated thrombosis
Abstract Introduction Clinical practice guidelines on cancer-associated thrombosis (CAT) recommend extended duration anticoagulation beyond...
Barriers and bridges: Real-world CAR T delivery across US oncology practices
Abstract Background: Chimeric antigen receptor T-cell (CAR T) therapy has transformed the treatment landscape for relapsed/refractory diffus...
Spatial anatomical genomic heterogeneity and aberrant somatic hypermutation define clonal evolution pathways that predict treatment resistance in aggressive B-cell lymphomas
Abstract Introduction: Large B-cell lymphomas (LBCL) exhibit intra-patient biologic heterogeneity. Single-site biopsies limit comprehensive...
The efficacy and safety of polatuzumab vedotin-based regimens in the treatment of diffuse large B-cell lymphoma: A retrospective real-world study
Abstract Background: Diffuse large B-cell lymphoma (DLBCL), the most common aggressive non-Hodgkin lymphoma, is characterized by high hetero...
A multivariable prediction model for early mortality in multiple myeloma patients with renal impairment
Abstract Background：Despite therapeutic advances, early mortality remains a major determinant of poor outcomes in patients with multiple my...
National trends and disparities in leukemia and septicemia-related mortality in theunited states from 1999-2023: A CDC wonder database analysis
Abstract Background: Leukemia, a type of cancer of the blood forming tissues, compromises the immune system putting the...
MYC/GSPT1 protein degradation in refractory/relapsed T-cell prolymphocytic leukemias
Abstract Background: T-cell prolymphocytic leukemia (T-PLLs) is a rare, mature T-cell-derived, aggressive hematologic malignancy. T-PLLs are...
Outcomes with azacitidine versus decitabine in AML/MDS
Abstract BACKGROUND: Azacitidine and Decitabine are widely used agents in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML),...
Not so exclusive: Co-mutations in JAK2, MPL and CALR define distinct hematologic and clonal signatures
Abstract Background: The canonical driver mutations in JAK2, CALR, and MPL are typically regarded as mutually exclusive...
Prognostic independence of double-hit multiple myeloma based on mayo definition, and nomogram was established
Abstract Introduction: Multiple myeloma (MM) is a heterogeneous diseases, and the existing risk stratification still has certain limitations...
ZAP trial: MRD-guided chemotherapy and maintenance de-escalation with zanubrutinib-g-CHOP in high-risk FL (Phase II)
Abstract Background: Patients with untreated follicular lymphoma (FL) and intermediate-high risk FLIPI scores (≥2) face poor outcomes: 5-yea...
cfDNA analysis for assessing spatial genomic heterogeneity in multiple myeloma with high metabolic uptake on PET/CT
Abstract Introduction Spatial genomic heterogeneity is a well-recognized characteristic of multiple myeloma (MM), contri...
Dual HDAC and EZH2 inhibition modulates RFX5 activity to increase the immunogenicity of germinal center-derived B-cell lymphoma
Abstract Chromatin-modifying genes, such as CREBBP and EZH2, are ubiquitously mutated in germinal center-derived B-cell (GCB) lymphomas, lea...
Decoding neurotoxicity: A multi-disease single-cell atlas of cerebrospinal fluid reveals conserved and context-specific pathogenic hallmarks
Abstract Introduction: Disease-induced neurotoxicity represents a significant clinical challenge across various neurological conditions, ca...
A first-in-class oral clinical candidate targeting MLLT1 and 3 degradation for the treatment of advanced AML and ALL including menin inhibitor resistant / refractory disease
Abstract Background: MLLT-1 and 3 proteins are highly homologous histone readers that are constitutive regulators of the Super Elongation Co...
A multicenter, open-label phase 1 study of INCB160058, a first-in-class JAK2V617F mutant–selective inhibitor, in patients with myelofibrosis, polycythemia vera, or essential thrombocythemia
Abstract Background and Significance: Current Janus kinase (JAK) inhibitors provide clinical benefit for patients (pts) with myeloproliferat...
Heterogeneity of treatment regimens and related health resource use in managing patients with waiha: A US multi-database retrospective observational Study
Abstract BackgroundWarm autoimmune hemolytic anemia (wAIHA) is clinically characterized by autoantibody-mediated (typically IgG) erythrocyte...
Using electronic-medical records to facilitate transition from pediatric to adult hematology for sickle cell disease
Abstract Transition of care from pediatric to adult hematology for adolescents and young adults (AYA) with sickle cell disease (SCD) is a co...
A non-telomeric role of POT1a in regulating HSC metabolism via TIN2 localization
Abstract Hematopoietic stem cells (HSCs) maintain long-term hematopoiesis through tightly regulated self-renewal and quiescence. Protection...
Comparative analysis of consolidation strategies after induction chemotherapy in primary central nervous system lymphoma
Abstract Background: Primary central nervous system lymphoma (PCNSL) is an aggressive diffuse large B-cell lymphoma, predominantly affecting...