Blood
Articles in this Issue
Elritercept shows durable responses in lower-risk myelodysplastic neoplasms (LR-MDS) with transfusion dependence: Updated Results from an ongoing Phase 2 trial
Abstract Background: Transfusion dependency is associated with substantial burden to patients with transfusion dependent anemia in the setti...
Hemophagocytic lymphohistiocytosis in the community: Real-world evidence and insights from a rare illness in the tertiary university system.
Abstract Background: Hemophagocytic Lymphohistiocytosis (HLH) is an immune hyperactivation disease characterized by widespread multiorgan da...
Phase II study of clia (cladribine, idarubicin, cytarabine) plus tyrosine kinase inhibitor (TKI) in patients with chronic myeloid leukemia in myeloid blast Phase
Abstract Introduction: Chronic myeloid leukemia in myeloid blast phase (CML-MBP) is an aggressive and uncommon clinical entity with limited...
Modifications in risk classification of acute myeloid leukemias undergoing less intensive chemotherapy comparing the 2022 and 2024 stratifications of the european leukemianet and their impact on treatment decision, response rates and outcomes of a brazilian cancer center.
Abstract INTRODUCTION: Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy with a genetic variability that plays a role i...
Efficacy and safety of OB756 (a Novel Selective JAK2 Inhibitor) for essential thrombocythemia in patients intolerant or resistant to hydroxyurea or interferon: A phase II, open-label, multicenter study
Abstract Background: OB756 is a novel, orally administered, selective JAK2 inhibitor that targets the JAK–STAT signaling pathway. It has bee...
Cost-conscious CAR T delivery: Outpatient (OP) cilta-cel administration reduces health care resource utilization (HCRU) and the associated post-infusion cost
Abstract Introduction: Cilta-cel is a BCMA-targeted CAR T cell therapy approved for the treatment of lenalidomide-refractory multiple myelom...
Reclaiming the clinical social work role: A call for reform in sickle cell disease psychosocial care
Abstract Background:Psychosocial services remain under-integrated and inconsistently supported in comprehensive sickle cell disease (SCD) ca...
A novel kinase-related gene signature predicts the survival and therapeutic responses of Acute Myeloid Leukemia
Abstract Background Acute Myeloid Leukemia (AML) is a malignant blood disease with a poor prognosis. Kinase plays an imp...
User experience with pegcetacoplan on-body injector in patients with paroxysmal nocturnal hemoglobinuria
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired condition characterized by complement-mediated hemolysi...
Long-term follow-up of novel post-transplant cyclophosphamide (PTCy) and abatacept (aba) graft-versus-host disease (GVHD) prophylaxis regimen compared to tacrolimus and methotrexate.
Abstract Introduction: Advances in relapse and GVHD prevention have led to improved effectiveness and safety of allogeneic hematopoietic cel...
Steroid-sparing use of anakinra for secondary hemophagocytic lymphohistiocytosis in sickle cell disease with multiorgan failure – a case report
Abstract Background: Sickle cell disease (SCD) can cause life-threatening multiorgan failure syndrome (MOFS) in the setting of fat embolizat...
Idiopathic multicentric castleman disease unresponsive to one IL-6 inhibitor may respond to another IL-6 inhibitor
Abstract Background Idiopathic multicentric Castleman disease (iMCD) is a morbid hematologic disorder defined by lymphadenopathy with a dist...
Impact of acute pain on health care resource utilization and costs in sickle cell disease in the United States
Abstract Objective: Acute pain is common among patients with sickle cell disease (SCD), but there is limited knowledge of its economic burde...
Platelet transfusion is associated with reduced thrombosis yet elevated mortality in consumptive thrombocytopenias: A retrospective cohort study
Abstract Background: Platelet consumptive disorders (immune thrombocytopenia [ITP], thrombotic thrombocytopenic purpura [TTP], heparin-induc...
Long-term cardiovascular outcomes in patients with lymphoma who had early post-CAR-T cardiovascular events: A multi-center, international study
Abstract Introduction: CAR-T is associated with a spectrum of acute toxicities, including acute cardiovascular events (CVE). The long-term ca...
Analysis of 3346 patients from the combined Children's Oncology Group AML studies further characterizes RAM immunophenotype AML and reveals other associated phenotypes and genetic drivers.
Abstract Introduction: RAM phenotype acute myeloid leukemia (RAM-AML), identified by flow cytometry at diagnosis, is associated with age und...
Defining therapeutic chimerism thresholds for comprehensive sickle cell disease correction in the townes mouse model
Abstract Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene, resulting in the production of an abnormal hemoglo...
Genome-wide association of pica within a cohort of volunteer blood donors implicates the gene encoding neuropeptide VF
Abstract Background: Pica is an eating disorder characterized by the persistent craving and consumption of non-food subs...
Enhancing somatic variant oncogenicity assessment – a prospective quality assurance study for rapid and scalable molecular profiling of hematological malignancies
Abstract Next-generation sequencing (NGS) of relevant genes offers critical insights into diagnostic, prognostic, and therapeutic biomarkers...
Pre-malignant extracellular matrix drives leukemia transformation through reprogramming of pre-leukemic stem cells
Abstract Acute myeloid leukemia (AML) often arises from myelodysplasia (MDS), a pre-leukemic condition characterized by dysplasia and ineffe...
Exploring the disease impact of plasma metabolites on marginal zone lymphoma based on mendelian randomization
Abstract Background: It is reported that altered plasma metabolite levels are associated with disease progression in marginal zone lymphoma...
Clinicopathological characteristics and survival outcomes in adults with acute megakaryoblastic leukemia
Abstract Background: Acute megakaryoblastic leukemia (AMKL, AML-M7) is a rare, biologically heterogeneous subset of Acute Myeloid Leukemia (...
Evaluating the clinical outcomes of GLP-1 receptor agonists in untreated indolent non-Hodgkin's lymphomas undergoing active surveillance
Abstract Background: In asymptomatic indolent non-Hodgkin lymphomas (iNHL) including follicular lymphoma (FL), mantle ce...
Efficacy and prognosis of venetoclax combined with the 3+7 regimen in fit AML: A propensity score-matched cohort study
Abstract Objective: To compare the efficacy and survival outcomes between the standard “3+7” regimen and the “3+7” regimen combined with ven...
Effectiveness and safety of polatuzumab vedotin in real-world clinical practice in Chinese patients with diffuse large B-cell lymphoma (POLAREAL): An interim analysis from a prospective, multicenter, observational registry study
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma. Polatuzumab vedotin (Pola) ha...