Blood
Articles in this Issue
Low dose AAV8-FVIII gene therapy on Chinese severe Hemophilia A patients with sustainable efficacy and safety
Abstract Introduction: Hemophilia A is an X-linked (FⅧ gene mutation) disorder of hemostasis that results in insufficient endogenous factor...
Efficacy and safety of gecacitinib in thrombocytopenic myelofibrosis patients
Abstract Introduction Despite recent advances in treating myelofibrosis (MF)-associated splenomegaly and symptoms, disease- and treatment-as...
A defined culture model for ex vivo expansion of primary AML cells preserves leukemic stem cells and clonal architecture for functional and therapeutic studies
Abstract First three authors contributed equally. Introduction: Acute myeloid leukemia (AML) is highly heterogeneous, and its ex vivo cultur...
Impact of 7-day versus standard venetoclax exposure in combination with azacitidine in frontline AML settings: A real-world analysis from the venaura retrospective multicenter study
Abstract Background: Azacitidine (AZA) plus venetoclax (VEN) is the standard first-line treatment for patients with acute myeloid leukemia (A...
Aplastic anemia in pregnancy: A case series review of hematologic parameters, treatment, and maternal-fetal outcomes
Abstract Introduction: Aplastic anemia (AA) affects approximately 1 in a million people per year in the United States and can present as a n...
Reduced intensive chemotherapy combined with venetoclax in adult patients with Acute Myeloid Leukemia: A retrospective single-center analysis
Abstract Background Intensive induction chemotherapy combination improves response rates in adult patients with acute my...
Evaluation of real-world outcomes among CLL patients based on sequencing of BTKi and BCL2i therapies
Abstract Background: Current first-line (1L) therapies for chronic lymphocytic leukemia (CLL) consist of Bruton tyrosine kinase inhibitors (...
Early-stage nodular lymphocyte predominant Hodgkin lymphoma: Disease characteristics, treatment pattern, and long-term outcomes from a tertiary care cancer institute in India
Abstract Background: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare & distinct subtype of Hodgkin...
Tocilizumab for cytokine release syndrome after allogeneic hematopoietic stem cell transplantation with post-transplant cyclophosphamide
Abstract Background: Post-transplant cyclophosphamide (PTCy)-based allogeneic hematopoietic stem cell transplantation (alloHCT) is frequentl...
Arsenite and its primary metabolite monomethylarsonous acid impair early human red blood cell development
Abstract Abstract: Chronic exposure to heavy metals, including arsenic, is linked to hematological disorders such as anemia. Both in vivo an...
Clinical and microbiological insights into invasive fusariosis following allogeneic hematopoietic stem cell transplantation: A 15-year single-center analysis
Abstract Introduction: Invasive fusariosis (IF) is a rare but life-threatening fungal infection that mainly affects immunocompromised patien...
Atypical IGH::CCND1 rearrangements by fluorescent in situ hybridization are associated with higher risk cytogenetic features in multiple myeloma
Abstract Background: The IGH::CCND1 rearrangement, resulting from a translocation between chromosomes 11q13 and 14q32, is one of the most co...
Autologous hematopoietic stem cell transplantation combined with inaticabtagene autoleucel in adults with high-risk B-cell acute lymphoblastic leukemia: Interim analysis of a phase II study
Abstract Introduction: Autologous hematopoietic stem cell transplantation (auto-HSCT) is an effective treatment option for patients with adu...
The recombinant adjuvant zoster vaccine induces similar immune responses in ruxolitinib-treated patients with myelofibrosis and polycythemia vera
Abstract Introduction: Patients with myeloproliferative neoplasms (MPN) such as myelofibrosis (MF) or polycythemia vera (PV) who are receivi...
Age at diagnosis drives molecular pathology and prognosis in diffuse large B-cell lymphoma
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma with significant pathological...
Longitudinal analysis of MRD negativity and immune dynamics in patients with transplant-ineligible newly diagnosed multiple myeloma treated with iberdomide, daratumumab, and dexamethasone from the CC-220-MM-001 trial
Abstract Introduction: Iberdomide (IBER) is an oral CELMoD™ agent with optimized cereblon binding leading to improved direct antitumor and i...
Evaluation of the combined effects of emicizumab and marstacimab in plasma from Hemophilia A patients using thrombin generation assay
Abstract Background: Patients with Hemophilia A (HA) may be treated with prophylactic emicizumab therapy, a bispecific monoclonal antibody t...
Decitabine enhances tumor immunogenicity via transposable element reactivation but concurrently induces oncogene expression in Acute Myeloid Leukemia
Abstract Background: Decitabine (DCB), a DNA methyltransferase inhibitor used in the treatment of acute myeloid leukemia (AML), induces glob...
Hospitalization and thromboembolic outcomes in patients with immune thrombocytopenic purpura and celiac disease: A retrospective cohort study
Abstract Background: Immune Thrombocytopenic Purpura (ITP) is an autoimmune condition characterized by isolated thrombocytopenia, with known...
Evaluation of real-world outcomes with zanubrutinib in patients with marginal zone lymphoma: Results from multicenter cohort study
Abstract Introduction: Zanubrutinib (zanu) received accelerated U.S. Food and Drug Administration (FDA) approval for patients (pts) with rel...
Dissecting mechanisms at an IKZF1 cis-regulatory element harboring ancestry-specific and cross-ancestry B-cell acute lymphoblastic leukemia risk variation
Abstract B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric cancer, with Hispanic/Latino (H/L) children in the United...
Revisiting the role of second allogeneic HCT for post-transplant relapse in acute lymphoblastic leukemia: Comparative outcomes in the era of targeted therapies
Abstract Background: Relapse after allogeneic hematopoietic cell transplantation (HCT) remains the leading cause of treatment failure in adu...
Correlation between efficacy, clonal dynamics evolution, and development of bone marrow failure in PNH/AA syndrome treated with complement inhibitors: A single-center cohort study
Abstract Objective: To investigate the correlation between therapeutic response patterns to complement inhibitors, clonal dynamics changes,...
Cladribine based salvage chemotherapy in AML patients with persistent or recurrent disease after venetoclax/HMA
Abstract INTRODUCTION In adults with acute myeloid leukemia (AML), the combination of venetoclax (ven) and a hypomethylating agent (HMA) rep...
Clinical characteristics and comutational landscape of CSF3R mutations in acute myeloid leukemia
Abstract Background Mutations in the colony stimulating factor 3 receptor (CSF3R) are the hallmark of chronic neutrophilic leukemia (CNL) an...