Blood
Articles in this Issue
Evaluating the clinical utility of soluble interleukin-2 receptor testing in diagnosing adult HLH: A single-center retrospective study
Abstract Introduction: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome characterized by uncontro...
DNA methylation markers assessed at birth are associated with future development of pediatric acute lymphoblastic leukemia
Abstract The underlying etiologic development of pediatric acute lymphoblastic leukemias (ALL) is not fully understood.While clinical outcom...
Real-world patterns of treatment intensity and prognostic model performance in older AML: Insights from the french ALFA-PPP cohort
Abstract Background: In older patients (pts) with newly diagnosed (ND) acute myeloid leukemia (AML), treatment options have expanded signifi...
Single-cell and spatial transcriptomics analyses decipher malignant B cell heterogeneity and immunosuppressive microenvironment in primary central nervous system lymphoma
Abstract Over 95% of primary central nervous system lymphoma (PCNSL) cases are histologically classified as diffuse large B-cell lymphoma (D...
Ruxolitinib concentrations in cerebrospinal fluid in patients with hemophagocytic lymphohistiocytosis and potential significance of central nervous system involvement
Abstract Hemophagocytic lymphohistiocytosis (HLH) constitutes a life-threatening hyperinflammatory state characterized by immune dysregulati...
Selective ASO-based JAK2 inhibitor for the treatment of hematological malignancies with JAK2 V617F mutation burden
Abstract Myeloproliferative disorders are clonal hematopoietic stem cell malignancies with cytokine independency or hypersensitivity. Due to...
Clinical safety of oral administration of hbi-002 carbon monoxide drug product in healthy subjects and individuals with sickle cell disease
Abstract HBI-002 is a liquid drug product containing carbon monoxide (CO) intended for oral administration with target peak CO-hemoglobin (C...
A phase 2 study of prophylactic intrathecal chemotherapy to prevent high-grade immune effector cell–associated neurotoxicity syndrome
Abstract Background: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a serious and potentially fatal toxicity associated w...
Lysophosphatidylcholine-induced macrophage polarization imbalance and functional dysregulation in immune thrombocytopenia
Abstract Introduction Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by reduced platelet counts and increased...
IHP-102 compound decreases the adhesion of sickle cell disease RBCs to acutely activated endothelial cells in biochip labs endothelial-on-a-chip assay
Abstract Background: The adhesion of red blood cells (RBCs) to the vasculature constitutes a pathophysiological manifestation of Sickle Cell...
Genetic and clinical profiles of chronic lymphocytic leukemia in Thailand: Nationwide insights from the thai lymphoma study group
Abstract Introduction: Genomic studies have illuminated the complex clonal heterogeneity of chronic lymphocytic leukemia (CLL) offering crit...
Efficacy and safety of R-CDOP in treatment-Naïve non-Hodgkin lymphoma with high tumor burden: A multicenter, prospective study
Abstract Background: Treatment of non-Hodgkin lymphoma (NHL) with high tumor burden remains challenging, and treatment with R-CHOP in this p...
Synergistic vulnerability of aggressive B-cell lymphoma to combined MCL-1 inhibition and CAR-T cell therapy
Abstract Aggressive B-cell lymphomas are often driven by MYC overexpression, which contributes to their rapid progression, therapeutic resis...
Impact of different Sf3b1 mutations on hematopoietic function and erythropoiesis
Abstract Myelodysplastic syndrome (MDS) is a group of hematological disorders defined by clonal expansion of hematopoietic stem cells (HSCs)...
Enumeration of plasma cells in the bone marrow of persons with multiple myeloma: Correlation between conventional panoptical microscopy of the aspirate, flow cytometry and bone marrow biopsy.
Abstract Background: The diagnosis of multiple myeloma (MM) needs the enumeration of the plasma cells (PC) in the bone marrow (BM); the perc...
Early Results of comparison of low-dose generic dasatinib (50 MG/Day) versus imatinib (400 MG/Day) in newly diagnosed chronic Phase chronic myeloid leukemia: Real-world evidence from a single-center, randomized controlled study from India
Abstract Background:Chronic myeloid leukemia is one of the most prevalent leukemias in the adult Indian population. Imatinib remains the TKI...
Poseltinib combined with rituximab and lenalidomide is a promising chemotherapy-free therapy in relapsed or refractory primary central nervous system lymphoma
Abstract Introduction Primary central nervous system lymphoma (PCNSL) is a rare and aggressive subtype of non-Hodgkin lymphoma with poor prog...
Pre-chemotherapy microbiome dysbiosis in hematologic malignancies
Abstract Background: The human gut microbiome plays a pivotal role in health and disease, influencing immunity, metabolism, and disease susc...
Simvastatin targets the cholesterol–bile acid axis to improve ALL survival by remodeling the metabolic microenvironment
Abstract Acute lymphoblastic leukemia (ALL) is a highly heterogeneous hematologic malignancy, with pathogenesis closely linked to metabolic...
Genomic landscape of mycosis fungoides
Abstract Introduction: Cutaneous T-cell lymphomas (CTCLs) are a rare, clinically heterogenous group of extranodal lymphomas that arise from...
Idiopathic multicentric castleman disease - tafro: A potentially curable disease?
Abstract Idiopathic multicentric Castleman disease (iMCD) is a group of rare and sometimes life-threatening hematological disorders.The Cast...
Iron overload is prevalent, likely underdiagnosed and undertreated in sickle cell disease: A real-world report from the ASH research collaborative
Abstract Introduction Despite the utility of red blood cell transfusion therapy for managing the acute and chronic compl...
Nationwide interpretable point‑of‑care score for CLL/SLL in‑hospital mortality with temporal validation and triage net benefit (NIS 2016–2022)
Abstract Background Inpatient mortality in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) approaches 6%, yet clinicians l...
Rehabilitation needs and predictors of functional outcomes following CAR T-cell therapy in lymphoma and multiple myeloma
Abstract Background: Chimeric antigen receptor (CAR) T-cell therapy is increasingly used for relapsed/refractory non-Hodgkin lymphoma (NHL)...
Targeted online education in obstetric hematology significantly improves resident knowledge and addresses a critical training gap
Abstract Introduction The care of pregnant individuals with hematologic disorders requires the expertise of two distinct medical specialties...