Blood
Articles in this Issue
Ethnic, racial, and geographic disparities in idiopathic thrombocytopenic purpura related mortality along the US-Mexico border from 1999 to 2020
Abstract Background: Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder marked by accelerated platelet destruction and impa...
Transcriptomic profiling of T cell immune states before and after donor lymphocyte infusion in a patient with acute myeloid leukemia
Abstract Background: One of the biggest challenges in optimizing immunotherapy for acute myeloid leukemia (AML) is the inability to predict...
Profiling drug sensitivity in CLL B cells after BTK inhibitor progression using a novel drug panel
Abstract Introduction: Although current clinical treatment approaches targeting Bruton Tyrosine Kinase (BTK) and BCL2, either as monotherapy...
Phase 3 randomized double-blind study evaluating selinexor, an XPO1 inhibitor, plus ruxolitinib in jaki-naïve myelofibrosis: Study rationale and preliminary patient characteristics
Abstract Background: Myelofibrosis (MF) is a myeloproliferative neoplasm driven by dysregulated JAK-STAT activity and inflammatory cytokine...
Synergistic targeting of KMT2A-rearranged AML with combined LSD1 and menin inhibitors
Abstract KMT2A-rearranged (KMT2Ar) acute myeloid leukemia (AML) is a high-risk subtype of AML associated with poor prognosis and frequent re...
Multi-omics profiling reveals an immunosuppressive microenvironment and PRL-3 as a therapeutic target in myeloma extramedullary disease
Abstract Background Extramedullary disease (EMD), an aggressive manifestation of multiple myeloma, remains a significant adverse prognostic...
Checkpoint inhibitors improve progression free survival after autologous transplant despite poorer pre-transplant response
Abstract Introduction The checkpoint inhibitors (CI) nivolumab and pembrolizumab which target PD1 are established treatments for relapsed/re...
The impact of frailty on real world outcomes for multiple myeloma patients in England – a cohort study from the uncover study group and ukmra frailty group.
Abstract Introduction Evidence for disease outcomes in Multiple Myeloma (MM) is largely derived from clinical trials whi...
Sasp-driven immune evasion defines a novel African ancestry-associated DLBCL subtype with distinctive molecular and immune vulnerabilities
Abstract Diffuse large B-cell lymphoma (DLBCL) arises at an earlier age and is associated with inferior survival in African American patient...
Investigating ribosome biogenesis in AML identifies MYB-binding protein 1A (MYBBP1A) as an essential regulator of leukemia cells
Abstract Ribosome biogenesis (Ribi) is essential to cellular function and often deregulated in cancer, making it an attractive therapeutic t...
Epik-L1: A Phase 2/3 study of alpelisib in pediatric and adult patients with PIK3CA-driven lymphatic malformations
Abstract Background and Significance: Lymphatic malformations(LyM) are rare, serious conditions, characterized by non-malignant masses consi...
Evaluating flow cytometry (FC) and next generation sequencing (NGS) for assessing minimal residual disease (MRD) and B-cell aplasia (BCA) in children, adolescents and young adults (CAYA) with B-cell acute lymphoblastic leukemia (B-ALL)
Abstract Background: Several biomarkers are utilized to monitor for B-ALL relapse. For minimal residual disease (MRD), these include flow cy...
Improved outcomes following allogeneic hematopoietic stem cell transplantation in patients with DDX41-mutated myeloid neoplasms: A prospective analysis of survival, GVHD, and transplant-related mortality
Abstract Introduction: Germline mutations in DDX41 represent a unique subgroup of hereditary myeloid neoplasms, most commonly acute myeloid...
Safety, tolerability and early efficacy of mdc-CAR-BCMA001 – a high affinity BCMA targeting CAR T-cell therapy in patients with multiple myeloma and diffuse large B-cell lymphoma
Abstract Background: BCMA is a validated target for T-cell engagers and chimeric antigen receptor (CAR) T-cell therapy i...
Analysis of published case reports on lymphoma using llms
Abstract Introduction: Lymphoma represents a diverse group of cancers with heterogeneous presentations, making treatment decisions complex....
Chidamide-BEAM conditioning plus autologous stem cell transplantation forperipheral t-cell lymphoma: A single-arm, single-center, phase 2 trial
Abstract Chidamide-BEAM Conditioning plus Autologous Stem Cell Transplantation for Peripheral T-cell Lymphoma: A single-arm, single-center, phase 2 trial...
Marvin: Deep generative model with structured latent space for flow cytometry cell classification and discovery of new population
Abstract BACKGROUND Mass or flow cytometry are used in research and clinical settings to analyze cell populations. It generates multidimensi...
T-lymphoblastic lymphoma presenting as pericardial tamponade: A rare initial manifestation of an aggressive malignancy
Abstract Background: T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) is a rare, aggressive neoplasm of precursor T-cells, typically affecting...
Baseline cytomegalovirus IgG levels predict reactivation in patients with multiple myeloma receiving elranatamab
Abstract Background: Elranatamab is a bispecific antibody approved for patients with triple-class exposed relapsed or refractory multiple my...
Intrathecal chemotherapy for management of immune effector cell-associated neurotoxicity syndrome (ICANS): A multi-center, real-world analysis of clinical outcomes
Abstract Background Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of large B-cell lymphoma (LBCL) but is l...
A unified nanopore-based approach for direct telomere sequencing and genetic diagnosis in inherited bone marrow failure syndromes
Abstract Introduction: Telomeres are repetitive sequences located at the ends of chromosomes. Impaired telomere maintenance in telomere biol...
NOXA modulates tipifarnib sensitivity in myeloid leukemia cells.
Abstract Tipifarnib is a potent small-molecule farnesyltransferase inhibitor (FTI) that has demonstrated single-agent activity in acute myel...
FLT3-ITD mutation promotes leukemic differentiation toward an immature cytotoxic stage
Abstract FLT3 mutations contribute to leukemogenesis and poor prognosis in acute myeloid leukemia (AML). Despite FLT3-targeted therapies, re...
Tailoring TBI for vulnerable patients: 8 gy TBI shows comparable outcomes to 12 gy TBI in adult ALL allo-HSCT
Abstract Introduction: Total body irradiation (TBI) is a standard component of conditioning regimens for allogeneic hematopoietic stem cell...
Spen loss drives extra-follicular diffuse large B cell lymphoma with female-specific lethality and TLR pathway therapeutic vulnerabilities
Abstract Diffuse large B cell lymphomas (DLBCL) are the most common lymphoid malignancies in adults. Despite advances in molecular classific...