Blood
Articles in this Issue
Rising mortality trends in elderly multiple myeloma patients with hypertension: A CDC wonder database analysis (1999–2023)
Abstract INTRODUCTION Multiple Myeloma (MM) is the second most fatal hematological malignancy after Acute Myeloid Leukemia (AML) and inciden...
Ex-vivo modification of autologous CD34+ HSPCs using a CD11B-directed lentiviral vector encoding APOEII-tagged human IDS leads to supraphysiological enzyme activity and early biochemical correction of neuronopathic mucopolysaccharidosis type II patients
Abstract Background: Mucopolysaccharidosis type II (MPSII, Hunter Syndrome) is a rare paediatric X-linked lysosomal storage disease caused b...
Trends in Acute Myeloid Leukemia mortality among patients with diabetes mellitus in the United States, 1999–2024: A CDC wonder database analysis
Abstract Abstract: INTRODUCTION: Diabetes mellitus (DM) is increasingly recognized as a comorbidity that complicates can...
NUP98 rearrangements (NUP98r) in Acute Myeloid Leukemia (AML): A genomic landscape study
Abstract Background: Nucleoporin 98 rearrangements (NUP98r) occur in a wide range of hematologic malignancies including AML and have been sh...
Trends in mortality from multiple myeloma in patients younger than 55 years of age in the United States: A retrospective analysis from 1999 to 2020
Abstract Background: Multiple myeloma is a malignancy of advanced age and is most commonly diagnosed in patients older than 65 years of age....
Harnessing repressive LEF1/β-catenin complexes to overcome drug resistance in chronic lymphocytic leukemia
Abstract Background and Significance. LEF1 is overexpressed and often used as diagnostic marker for CLL. LEF1 is a transcriptional target an...
Impact of EBV status on the characteristics and prognosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients: Long-term experience from the GELTAMO group
Abstract Introduction Post-transplant lymphoproliferative disorders (PTLD) are a heterogeneous group of immunosuppression-related conditions...
Transition to fellowship: A qualitative exploration of the experience of hematology-oncology fellowship at the university of Colorado
Abstract Background: The transition from internal medicine residency to fellowship is a crucial phase as physicians terminally differentiate...
primary efficacy and safety of first-line R-MTO regimen (rituximab, methotrexate, thiotepa, and orelabrutinib) followed by autologous hematopoietic stem cell transplantation in PCNSL
Abstract Background: Primary central nervous system lymphoma (PCNSL) is a rare and aggressive B-cell malignancy with poor long-term survival....
Prolyl-tRNA synthetase inhibition disrupts oncogenic translation in T-cell acute lymphoblastic leukemia
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer marked by the abnormal growth of immature thymocytes. 5-y...
Efficacy and safety analysis of letermovir for the prevention of CMV infection after haploidentical hematopoietic stem cell transplantation in children with acute leukemia
Abstract Introduction: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative approach for childhood acute leukemia. I...
Adapted physical activity during first line therapy in multiple myéloma : Innovative assessment of physical status during first-line therapy in 22 multiple myeloma patients
Abstract Background Multiple myeloma (MM) patients have been first excluded from exercise programs due to their pain and fracture risk. Howe...
Technical benchmarking of eight machine‑learning algorithms versus penalized logistic regression for predicting in‑hospital death in 117,765 u.S. CLL/SLL admissions
Abstract Background Machine-learning (ML) is widely promoted for hospital risk prediction, yet its incremental value over well-specified sta...
Long-read direct RNA-seq reveals dynamic MM transcriptome made of novel isoforms and post-transcriptional modifications
Abstract Background: Increasing evidence indicates considerable heterogeneity in multiple myeloma (MM) clinical course and treatment response...
Oral VP16 combined with ATRA and realgar-indigo naturalis formula as complete oral induction regimen is an fast，safe and effective regimen during induction to reduce mortality in high-risk acute promyelocytic leukemia
Abstract Background： Early death in high-risk acute promyelocytic leukemia (APL) is closely related to the leukocytosis at the onset of the...
Allogeneic hematopoietic stem cell transplantation in sil::TAL1-positive T-ALL: Prognostic impact of pre-transplant remission and molecular status
Abstract Introduction The SIL::TAL1 fusion gene, caused by a 1p32 deletion, is a common molecular alteration in T-cell acute lymphoblastic l...
Comparing the accuracy of natural language processing labelling versus manual chart review and ICD-10 codes to identify bleeding events in patients with cancer
Abstract Background: Identifying bleeding events in the electronic health record (EHR) is challenging and often requires laborious manual ch...
Comparative high-dimensional profiling reveals distinct immune reconstitution dynamics between CD19 and CD7 CAR-T therapies in acute leukemia
Abstract Background: Chimeric antigen receptor T-cell (CAR-T) therapies targeting distinct lineage antigens such as CD19 (B-cell) or CD7 (T-...
Bridging the gap between protocol and practice: A quality improvement initiative to optimize platelet use in a community healthcare setting
Abstract Introduction: Platelet transfusion (PLT) is a critical intervention used to prevent or manage bleeding in individuals with platelet...
Changing patterns and comparative outcomes of “watch-and-wait” versus immediate therapy in CLL: A propensity-weighted SEER analysis, 2000–2020
Abstract Background: Chronic lymphocytic leukemia (CLL) exhibits a broad clinical spectrum, ranging from indolent lymphocytosis to aggressiv...
Nutrition needs assessment for sickle cell disease throughout the lifespan
Abstract Introduction: Patients with sickle cell disease (SCD) experience a range of debilitating symptoms, including vaso-occlusive crises...
Impact of social determinants on inpatient outcomes in hairy cell leukemia: A national cohort study
Abstract Background: Hairy Cell Leukemia (HCL) is a rare, indolent B-cell lymphoproliferative disorder with a generally favorable prognosis...
Impact of fatigue on health care resource utilization and costs in sickle cell disease in the United States
Abstract Introduction: Fatigue is a common symptom of sickle cell disease (SCD). However, the economic burden associated with fatigue among...
Discovering the epidemiology, treatment patterns, and outcomes of chronic lymphocytic leukemia: A retrospective multicenter cohort study
Abstract Introduction Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults in Western countries, wit...
Rapid DNA-methylation based classification of hematological malignancies
Abstract Accurate molecular classification of hematological malignancies is essential for treatment and prognosis. Current diagnostic workfl...