Blood
Articles in this Issue
Physiologic oxygen expansion of murine lineage negative bone marrow cells enhances lymphocyte recovery following transplantation
Abstract Rapid recovery of lymphocytes post hematopoietic cell transplantation (HCT) is correlated with positive patient outcome in treatmen...
NUP98-rearranged pediatric AML is sustained by a conserved leukemia stem cell program with SPNS2/3 as a targetable vulnerability
Abstract Pediatric acute myeloid leukemias (AML) are genetically and molecularly diverse. Pediatric AML carry a range of different driver mu...
JS203, a CD20×CD3 bispecific antibody, demonstrated promising anti-cancer activity in patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL): Updated results from a phase I study
Abstract Introduction JS203 is a bispecific CD20 x CD3 antibody, with a lower affinity for CD3 than other products in the class. The Phase I...
Reproductive health across the lifespan in acute hepatic porphyria
Abstract INTRODUCTION The acute hepatic porphyrias (AHPs) are disorders of heme biosynthesis characterized by neurovisceral symptoms and sign...
Real-world treatment patterns and outcomes of first-line luspatercept in patients with myelodysplastic syndromes in the United States
Abstract Background: Patients with lower-risk myelodysplastic syndromes (LR-MDS) who experience anemia require strategie...
QLS4131, a next-generation GPRC5D×BCMA×CD3 trispecific T-cell engager, in patients with relapsed/refractory multiple myeloma (RRMM): Initial results of a first-in-human Phase Ⅰa study
Abstract Background: Bispecific antibodies targeting B-cell maturation antigen (BCMA) and G protein-coupled receptor class C group 5 member...
Healthcare inequities in Latin America outweigh the benefits of pediatric regimens in adult acute lymphoblastic leukemia
Abstract Background: In Latin America, leukemia care is delivered through two distinct healthcare systems: a public health system, which ser...
Outcome after relapse in older patients with Philadelphia Chromosome–Negative B-cell ALL treated with inotuzumab ozogamicin and low-dose chemotherapy in first-line therapy: A graall study
Abstract Background: With the advent of immunotherapy, the prognosis of older patients with Philadelphia-negative (Ph-neg) B-cell acute lymph...
Discovery of drug combinations with momelotinib to improve myelofibrosis outcomes
Abstract Momelotinib (Ojjaara / Omjjara) is a clinically differentiated JAK inhibitor that improves the key manifestations of myelofibrosis...
National trends in acute lymphocytic leukemia (ALL) incidence (1999–2021): A longitudinal outcome study using joinpoint analysis of age, sex, and regional disparities
Abstract INTRODUCTION Acute Lymphocytic Leukemia (ALL) is a highly aggressive hematological malignancy characterized by rapid proliferation o...
Real world experience of alpha-1 antitrypsin in steroid-refractory acute graft versus host disease: Higher durable response rate compared to ruxolitinib
Abstract Background Steroid-refractory acute graft versus host disease (SR-aGVHD) can be a life-threatening complication...
Netrin-1 regulates hematopoietic stem cell function via UNC5A
Abstract Aging is associated with an increased susceptibility to hematopoietic deficiencies and a reduced tolerance to therapeutic myeloabla...
Clinically meaningful improvement of the modified lee symptom score in patients treated with belumosudil for steroid-refractory chronic GVHD: Evidence from Canadian real-world outcomes
Abstract Introduction Belumosudil (BEL), a selective Rho-associated coiled-coil kinase 2 (ROCK2) inhibitor, has shown clinical efficacy in t...
Venetoclax in combination with hypomethylating agents in adult patients with newly diagnosed AML with CBFB::MYH11 or RUNX1::RUNX1T1 fusions: Real-world outcomes based on international registry data
Abstract Introduction Patients (pts) with core-binding factor (CBF) AML (defined by inv(16)(p13.1q22) or t(16;16)(p13.1;q22)/CBFB::MYH11 or...
A novel immune signature characterized by activation of the IFNγ-IL18 axis identifies immune effector cell-associated HLH-like syndrome after CD22 chimeric antigen receptor T-cell therapy
Abstract Introduction: Immune effector cell-associated hemophagocytic-like syndrome (IEC-HS) is an increasingly recognized, life-threatening...
Adding selinexor to ifosfamide, etoposide and desametasone does not improve the outcome in relapsed and refractory peripheral T-cell lymphomas: First report of phase II S-ide study.
Abstract Introduction: The prognosis of relapsed or refractory (R/R) Peripheral T-cell lymphomas (PTCL) is very poor, except for CD30+ ALK p...
Short-term blinatumomab regimen in newly diagnosed induction and MRD-negative consolidation treatment of B-cell acute lymphoblastic leukemia
Abstract Background: Blinatumomab, a bispecific antibody engaging CD3 positive T cells to CD19 positive tumor cells, has demonstrated efficac...
Negative regulators of survival and proliferation (NRSPs) identified by CRISPR activation studies in multiple myeloma (MM) vs. other neoplasias: Therapeutic implications
Abstract Background - Methods: Hundreds of cell lines have been examined by genome-sale CRISPR knockout (KO) studies to identify functional...
Targeting the protein S–C4BP-β interaction: A potential therapeutic strategy for hemophilia B
Abstract Protein S (PS) is a vitamin K-dependent, multi-domain glycoprotein composed of an N-terminal γ-carboxyglutamic acid (Gla) domain, a...
Stage 0+ lower gastrointestinal (LGI) acute graft-versus-host disease (aGVHD) is associated with high response to non-systemic treatment, low incidence of moderate to severe chronic graft-versus-host disease (cGVHD) and low non-relapse mortality (NRM)
Abstract Introduction: LGI aGVHD remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (alloH...
A single cell multiomic approach to dissect immunophenotypic plasticity in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) pediatric patients
Abstract Acute lymphoblastic leukemia (ALL) is the most common cancer in childhood, accounting for about 20% of all pediatric malignancies w...
The role of aging in promoting leukemia progression through cell-intrinsic and cell-extrinsic mechanisms
Abstract Age is the single major risk factor for numerous cancer types including leukemia. Due to population aging, it is evident that cance...
Minimally invasive assessment of peripheral residual disease (PRD) during maintenance or observation in patients (Pts) with multiple myeloma (MM): An update from the GEM2017FIT clinical trial
Abstract Background. The expectation of a treatment-free interval in pts achieving deep and durable MRD responses, as well as the possibilit...
Trends in Acute Myeloid Leukemia mortality among patients with myelodysplastic syndrome in the United States (1999–2024): A CDC wonder database analysis
Abstract INTRODUCTION: Myelodysplastic syndromes (MDS) are known precursors to acute myeloid leukemia (AML), especially in older adults, whe...
Real-world treatment characteristics and outcomes in patients with von Willebrand disease treated prophylactically with plasma-derived or recombinant von Willebrand factor in europe: A multi-center, retrospective study
Abstract Introduction Von Willebrand disease (VWD) is an inherited bleeding disorder caused by deficiencies in the conce...