Blood
Articles in this Issue
primary prophylaxis with direct oral anticoagulants (DOACs) for transwomen taking estrogen is not cost-effective
Abstract Introduction: Gender affirming hormonal therapy (GAHT), particularly estrogen-based regimens, is a vital part of gender-affirming c...
Simultaneous PD-1 and VIP receptor blockade optimizes tumor immunotherapy in P815 Acute Myeloid Leukemia model
Abstract Anti-programmed death-1 (PD-1) therapy enhances anti-tumor immunity in many solid tumors, but is largely ineffective in acute myelo...
Association of social determinants of health (SDoH) with clinic visit adherence, healthcare utilization and hydroxyurea (HU) acceptance and adherence in children with sickle cell disease (SCD)
Abstract Background: Children with chronic diseases living in deprived neighborhoods have lower medication adherence and poorer health outco...
A novel protocol of dual passing cord blood pre-/post-transplant reduced relapse in TCRαβ cell depleted HCT
Abstract Background How to overcome post-transplant relapse (PTR) is the main challenge in current. PTR is 20% or higher in haplo-HCT. An ad...
Unexplained bleeding and a hidden inhibitor: A case of late-onset acquired hemophilia A
Abstract Background: Acquired hemophilia A (AHA) is a rare autoimmune bleeding disorder caused by autoantibodies against...
Phase II Trial of lenalidomide plus rituximab (R2) in previously untreated follicular lymphoma: 15-year follow up data from MDACC Trial
Abstract Introduction: Lenalidomide with rituximab (R2) as first line treatment for patients with previously untreated follicular lymphoma (...
Risk factors for disseminated intravascular coagulation in pediatric acute promyelocytic leukemia: Insights from the cclg-APL 2016 study
Abstract Purpose: To identify early risk factors for DIC, particularly severe DIC (grade 4-5), in pediatric APL, with the aim of guiding ear...
Charlotte African American MGUS project (CHAAMP): A prospective pilot study of MGUS screening in black and/or African American adults
Abstract Background Among Black and/or African American individuals, multiple myeloma (MM) is the most common hematologic malignancy, occurr...
Post-traumatic stress disorder in patients with multiple myeloma (MM) and non-Hodgkin lymphoma (NHL)
Abstract Background Multiple Myeloma (MM) and non-Hodgkin lymphoma (NHL) are hematologic malignancies contributing...
Clinical and experimental characteristics of a hereditary thrombocythemia family with co-mutation in JAK2 involving ferm and pseudo-kinase domains
Abstract Objective: To enhance understanding of familial hereditary thrombocythemia (HT) associated with novel JAK2 germline mutations and i...
Risk stratification based on machine learning for severe cytokine release syndrome in RRMM patients treated with bispecific antibodies
Abstract Introduction T-cell redirecting bispecific antibodies (BsAbs) have significantly advanced treatment of relapsed/refractory multiple...
Impact of allogeneic transplant vs hypomethylating agents in high-risk myelodysplastic syndromes: A prisma-guided systematic review
Abstract Background High-risk myelodysplastic syndromes (MDS)—those falling into IPSS Int-2/High or IPSS-R High/Very-High categories—still c...
Umbilical cord blood CD34+ hematopoietic stem cell-derived natural killer cells in Acute Myeloid Leukemia – a phase I clinical study
Abstract Background: The use of fresh umbilical cord blood (UCB) CD34+ hematopoietic stem cell (HSC)-derived allogeneic natural killer (NK)...
TP53 mutational spectrum and fitness landscape in myeloid neoplasia
Abstract Myeloid neoplasia encompasses a heterogeneous and complex molecular landscape whereby the distinct combinatorial patterns associate...
Transduction efficiency and vector biodistribution following prenatal vs neonatal AAV5 gene therapy for Hemophilia A in a sheep model
Abstract Hemophilia A (HA) patients treated with AAV-based gene therapy (GT) receive vector serotypes that preclinical studies indicated to...
Differences in patient-reported time toxicity between bispecific antibody (BsAb) options: Impact of treatment duration and dosing frequency on patient-reported time burden in relapsed/refractory (R/R) follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL)
Abstract Background Several BsAbs with different treatment (Tx) approaches have been approved by the FDA for Tx of lymphoma, including: fixe...
Odronextamab treatment for patients with rare subtypes of relapsed/refractory (R/R) aggressive B-cell non-Hodgkin lymphoma (B-NHL): Updated efficacy and safety analyses from a dedicated cohort of the ELM-2 study
Abstract Introduction Aggressive B-NHL includes rare subtypes such as transformed diffuse large B-cell lymphoma (t-DLBCL...
A US real-world analysis of demographics, transplant patterns, and survival outcomes in posttransplant lymphoproliferative disorder (PTLD)
Abstract Introduction: Posttransplant lymphoproliferative disorder (PTLD) is a rare but serious complication that can occur following solid...
T cell resistance to glucocorticoids in graft-versus-host disease
Abstract Glucocorticoid (GC)-resistant, acute graft-versus-host-disease (GVHD) is a major cause of mortality following allogeneic hematopoie...
Incidence of arterial thromboembolism in patients with myeloproliferative neoplasms treated with anticoagulation for venous thromboembolism
Abstract Background Patients with myeloproliferative neoplasms (MPN) have a high lifetime risk of both venous thromboembolism (VTE) and arter...
The efficacy of immunotherapy in alveolar soft part sarcoma (ASPS): A case report
Abstract Introduction: Alveolar Soft Part Sarcoma (ASPS) is an extremely rare sarcoma, accounting for 1% of soft tissue tumors that predomin...
Liquid biopsy for non-invasive molecular characterization and measurable residual disease analysis in multiple myeloma
Abstract Introduction: Molecular profiling and measurable residual disease (MRD) assessment have become essential in multiple myeloma (MM) d...
Xeroderma pigmentosum as a germline predisposition syndrome for haematological malignancies
Abstract IntroductionXeroderma pigmentosum (XP) is a rare autosomal recessive disorder caused by defects in the nucleotide excision repair p...
Pomalidomide promotes activation induced cell death of pre-activated, memory BCMA CAR-T cells in a model of high, but not low, tumor burden multiple myeloma
Abstract Introduction High disease burden has been associated with reduced efficacy and resistance to BCMA CAR-T therapy in relapsed/refract...
Bone marrow environmental alterations underlie proliferative clonal expansion in clonal hematopoiesis
Abstract Background Age-related clonal hematopoiesis (CH) is common in the elderly and associated with increased risk of hematologic maligna...