Blood
Articles in this Issue
Leveraging clonal competition between chip and malignant clones as a novel therapeutic strategy in hematologic malignancy
Abstract Hematopoiesis is a polyclonal process in which hematopoietic stem cells (HSCs) are in constant competition within the bone marrow n...
Demographic and clinical risk factors for renal complications and associated non-relapse mortality in hematopoietic stem cell transplantation
Abstract Background Acute kidney injury (AKI) and chronic kidney disease (CKD) are common complications following alloge...
Real-world safety and mortality outcomes of CAR-T cell therapies versus bispecific antibodies in DLBCL: Insights from the faers database
Abstract Introduction: Relapsed or refractory diffuse large b-cell lymphoma (R/R DLBCL) is associated with poor prognosis. Novel treatment m...
Infections in patients with relapsed refractory multiple myeloma receiving idecabtagene vicleucel therapy: A real-world analysis from CIBMTR
Abstract Background: Infections account for over half of the non-relapse deaths among chimeric antigen receptor (CAR) T-cell recipients. Non...
Efficacy and safety of CAV (cladribine, cytarabine and venetoclax) regimen in patients with newly diagnosed Acute Myeloid Leukemia
Abstract To explore the efficacy and safety of CAV regimen in newly diagnosed acute myeloid leukemia (AML). This study was registered in the...
DNA methylation variability in pediatric aplastic anemia contributes to T cell differentiation
Abstract Aplastic anemia (AA) is caused by immune-mediated bone marrow failure and exhibits an inexplicable peak of age distribution in chil...
Trends and disparities in nutritional anemia-related mortality in the elderly in theunited states from 1999 to 2023: A CDC wonder database analysis
Abstract Introduction: Nutritional anemia represents a common and significant public health challenge in the elderly. Nutritional anemia inc...
The ABC-14 regimen (Azacitidine, Venetoclax, and Chidamide) as a bridge to allogeneic hematopoietic stem cell transplantation for Acute Myeloid Leukemia: A single-center experience
Abstract Background: The combination of azacitidine, venetoclax, and chidamide (ABC-14 regimen) has demonstrated efficacy comparable to “3+7...
First evaluation of novel cmoep (Liposomal Mitoxantrone-Based Chemotherapy) in front-line peripheral T-cell lymphoma: The compass Phase II study
Abstract Background: Peripheral T-cell lymphoma (PTCL) is a heterogeneous and aggressive group of lymphoma, accounting for 25%~30% of non-Hod...
Thrombotic and hemorrhagic events and their impact on mortality among adults with newly diagnosed acute myeloid leukemia
Abstract Introduction Patients with acute myeloid leukemia (AML) are at increased risk of both thrombosis and bleeding a...
Impact of the CAR-T era on survival in diffuse large B-cell lymphoma: A u.S. population-based cohort study
Abstract Background: Historically Diffuse large B-cell lymphoma (DLBCL) had poor long term survival especially in relaps...
Utilizing the complete blood count (CBC) and blood smear analysis to improve pediatric residents' skills and knowledge in hematology
Abstract Background: Effective learning in medical education often integrates knowledge with clinical activities, particularly through hands...
Pegcetacoplan for patients with transplant-associated thrombotic microangiopathy treatment: A real-world report of six cases
Abstract Background: Transplant-associated thrombotic microangiopathy (TA-TMA) is a severe, life-threatening complication of hematopoietic s...
Cytotoxic lymphoma assessment response (CLyAR): A harmonized, compartment-based consensus response assessment framework for cytotoxic T-cell lymphomas
Abstract Background: Cytotoxic T-cell lymphomas (CTLs) are rare, comprising only 3–5% of all Mature T-cell lymphomas and have very poor outc...
Integrating clinical features, long-term Outcomes and NGS-based mutational analysis in AYA patients with essential Thrombocythemia and polycythemia vera: A Multicenter Retrosepective study
Abstract Introduction: Essential thrombocythemia (ET) and polycythemia vera (PV) are myeloproliferative neoplasms (MPN)...
Final results of a first-in-human Phase I study of INA03, a novel CD71/TfR1-targeted antibody-drug conjugate, in patients with relapsed or refractory acute leukemia.
Abstract Background: CD71/TfR1 (transferrin receptor 1) is highly expressed in proliferative malignancies, including acute leukemias, and is...
Quantifying hemolytic response in sickle cell disease blood to mechanical and hypoxic stressors
Abstract Introduction Sickle cell disease (SCD) leads to ongoing destruction of red blood cells (RBCs) within blood vessels, driven by the f...
A Phase 2, multicenter, open-label, single-arm study assessing a 4-weekly dosing schedule for mogamulizumab in patients with mycosis fungoides/Sézary syndrome (MOGA-2MG-Q4W)
Abstract Introduction Mogamulizumab (moga), a monoclonal antibody targeting chemokine receptor 4 (CCR4), is approved for relapsed/refractory...
Diagnostic and therapeutic patterns in cutaneous T-cell lymphomas (CTCL): Real-world data from the lymphoma epidemiology outcome-molecular epidemiology resource (LEO-MER) prospective cohort study.
Abstract Introduction: CTCLs are rare, heterogeneous non-Hodgkin lymphomas (NHL) with significant regional variability in treatment patterns...
Transformer neural network using DNA methylation for sensitive and specific diagnosis of acute leukemia
Abstract Introduction The 2022 WHO Classification of Pediatric Tumors marked a major step forward in molecular diagnostics. DNA-methylation...
Real world population-based outcome analysis of small lymphocytic lymphoma (SLL) in British Columbia (BC)
Abstract Background: Small lymphocytic lymphoma (SLL) primarily involves lymph nodes (LNs) and is considered biologically identical to its p...
Geographic, demographic, and risk factor burden of multiple myeloma in the United States: Insights from the global burden of disease study 2021
Abstract Background: Multiple myeloma (MM) is a plasma cell malignancy with substantial morbidity and mortality. Understanding geographic an...
P2rx7 in AML blasts orchestrates myeloid differentiation through T cell-mediated visfatin and lymphotoxin signaling
Abstract Introduction:P2X7 receptor (P2RX7) overexpression has been found to be associated with a poor prognosis in human acute myeloid leuk...
A case of composite lymphoma and multiple cancer diagnoses in an individual heterozygous for FANCI variant
Abstract Here we report a case of multiple malignancies in a patient with a history of superficial basal cell carcinoma (BCC) and seborrheic...
Y chromosome loss drives sex disparities in multiple myeloma by reshaping the immune landscape
Abstract Sex-based differences in cancer incidence and prognosis remain incompletely understood. Loss of the Y chromosome (LOY)-the most com...