Blood
Articles in this Issue
Acute promyelocytic leukemia incidence in Andean highlanders with the NFKB1 haplotype (rs230511)
Abstract Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML), characterized by the oncogenic fusion pro...
Bispecific antibodies in real-world care of multiple myeloma: Patient characteristics and healthcare resource utilization
Abstract Introduction: Bispecific antibodies (BsAbs) including teclistamab (tec), talquetamab (talq), and elranatamab (elra) have emerged as...
粪便微生物移植在治疗类固醇难治性胃肠道移植物抗宿主病中的应用
Abstract Objective To assess the efficacy and safety of fecal microbiota transplantation (FMT) in the treatment of gastrointestinal graft-ve...
The treatment of patients primary refractory or with sub-optimal response to d-VTD induction: An italian real-life Study
Abstract Despite the improvement in the treatment of multiple myeloma (MM) patients, there is still a consistent fraction of patients who ha...
Real-world impact of lipophilic statins on survival outcomes in polycythemia vera and essential thrombocythemia
Abstract Background: Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative neoplasms frequently associate...
Type and degree/number of immunophenotypic abnormalities refine multiparameter flow cytometry (MFC)-based measurable residual disease (MRD) testing in adults allografted for Acute Myeloid Leukemia (AML) in morphologic remission
Abstract Introduction : MFC-based MRD testing is now routinely used in AML, but methodological refinements are needed to optimize assay perfo...
Evaluating large language models in real-world hematologic clinical decision-making: Performance, limitations, and clinical implications
Abstract Background Recent advances in Artificial Intelligence (AI), particularly in Large Language Models (LLMs) like GPT-4o (ChatGPT) and...
Time-limited acalabrutinib monotherapy in frail patients with previously untreated chronic lymphocytic leukemia: Primary endpoint analysis of the randomized STAIR trial.
Abstract Background Continuous therapy with covalent BTK inhibitors (BTKi) has become a cornerstone strategy for patients with chronic lymph...
Gut microbiota-mediated tryptophan metabolism plays dual-effects in diffuse large B-cell lymphoma via regulating 3-IAA/5-HTP balance and antitumor immunity
Abstract Introduction: Diffuse large B-cell lymphoma (DLBCL), the most common aggressive lymphoma, exhibits limited immunotherapeutic respons...
The selective PI3Kδ inhibitor roginolisib synergizes with ruxolitinib against progenitor cells from naïve and JAK inhibitor-refractory/resistant patients with myelofibrosis
Abstract BACKGROUND. Following demonstration of abnormally activated JAK2/STAT signalling caused by driver mutations in JAK2, CALR, MPL, JAK...
Impact of broad-spectrum antibiotic exposure on outcomes following autologous stem cell transplantation for patients with relapsed diffuse large B-cell lymphoma or Hodgkin lymphoma
Abstract Introduction: Autologous hematopoietic stem cell transplantation (ASCT) has curative potential for relapsed dif...
Non-CLL-type MBL and chip are associated precursor conditions: Insights from Mayo Clinic's MBL screening cohort
Abstract Background: Monoclonal B-cell lymphocytosis (MBL), a precursor to chronic lymphocytic leukemia (CLL), is an understudied yet common...
iPSC-derived epstein-barr virus-specific T cells with dual alpha T cell receptors
Abstract T cells play a critical role in immune defense by eliminating virus-infected and malignant cells. Their antigen specificity is dete...
Consolidation of adult inpatient sickle cell care to improve patients' and learners' experiences: A qualitative exploration of various stakeholders' perspectives
Abstract Background: SCD patients are often scrutinized by healthcare providers during acute illness: their pain is often doubted, and they...
Comparison of autologous HCT versus haploidentical donor HCT for Ph+ B-ALL patients following TKI therapy. a study from the global committee and the acute leukemia working party of the european society for blood and marrow transplantation
Abstract Introduction While the tyrosine kinase inhibitors (TKIs) have dramatically improved outcomes for Philadelphia chromosome-positive B...
Adverse event profiles of acalabrutinib and zanubrutinib in chronic lymphocytic leukemia: A real-world comparison
Abstract Background: Bruton's tyrosine kinase inhibitors (BTKis), like acalabrutinib and zanubrutinib, have revolutioniz...
Updated efficacy and safety results of the Bruton tyrosine kinase degrader BGB-16673 in patients with relapsed/refractory Waldenström macroglobulinemia from the ongoing phase 1 CaDAnCe-101 study
Abstract Introduction: BGB-16673 is an orally available protein degrader that blocks BTK signaling by tagging BTK for degradation through the...
Impact of slim-CRAB criteria on diagnostic practices among patients with MGUS in the veteran health administration
Abstract Introduction In 2014, the International Myeloma Working Group (IMWG) modified the diagnostic criteria for active multiple myeloma (M...
Sustained improvements in patient-reported outcomes after intravenous efgartigimod in adults with primary immune thrombocytopenia in a Phase 3 clinical trial (ADVANCE IV) and the first 52 weeks in its open-label extension study (ADVANCE IV+)
Abstract Introduction Primary immune thrombocytopenia (ITP) is an acquired autoimmune disorder resulting in thrombocytopenia, bleeding, cons...
External validation of the istopmm prediction model in a US population
Abstract Background: The iStopMM Prediction Model was developed to predict the probability of ≥10% bone marrow plasma cells (BMPC) in patien...
Vexas syndrome in Germany: Insights from a prospective registry on clinical presentation, management and outcomes
Abstract Background VEXAS syndrome (vacuoles, E1 enzyme, x-linked, autoinflammatory, somatic) is an acquired hematoinflammatory disorder cau...
Early discharge program cost savings for patients with newly diagnosed acute myeloid leukemia after intensive induction chemotherapy
Abstract Introduction: Patients with newly diagnosed acute myeloid leukemia (ndAML) often undergo frontline intensive ch...
Refining the prognostic hierarchy of TP53 multihit alterations and isolated deletion of chromosome 5q in myelodysplastic syndromes
Abstract Background & aim: Myelodysplastic syndromes with isolated deletion of chromosome 5q (MDS-del(5q)) are associated with low-risk...
Standard tyrosine kinase inhibitor dose versus dose de-escalation prior to treatment-free remission attempt in chronic myeloid leukemia: A single-center 25-year retrospective study
Abstract Background As frontline treatment for CML, tyrosine kinase inhibitors (TKIs) have significantly improved patient prognosis and can...
Efficacy and safety of frail adults treated with ciltacabtagene autoleucel in the real-world: A CIBMTR analysis
Abstract Background: Ciltacabtagene Autoleucel (Cilta-cel), an anti-BCMA CAR-T cell therapy, is approved for relapsed/refractory multiple my...