Blood
Articles in this Issue
Peripheral blood or bone marrow grafts for unrelated donors with posttransplant cyclophosphamide-based graft-versus-host disease prophylaxis
Abstract Introduction Peripheral blood (PB) grafts are a well-known risk factor for graft-versus-host disease (GVHD) in...
The enrichment of T-regulatory cells as a potential therapeutic approach for cerebral vasculopathy in sickle cell disease
Abstract Cerebral vasculopathy is a major contributor to morbidity and mortality in sickle cell disease (SCD). The complex interactions betw...
Social determinants of health and outcomes of bone marrow transplantation in patients with aplastic anemia: A 23-year retrospective cohort study
Abstract Introduction: Bone marrow transplantation (BMT) outcomes in patients with aplastic anemia (AA) have significantly improved during t...
Characteristics and treatment patterns of nontransplanted patients with newly diagnosed multiple myeloma treated with daratumumab, bortezomib, lenalidomide, and dexamethasone (DVRd) or daratumumab, lenalidomide, and dexamethasone (DRd) in the frontline setting
Abstract Introduction: DRd is the standard of care for frontline (FL) treatment (tx) of transplant-ineligible (TIE) patients with newly diag...
Estimating incident and prevalent essential thrombocythemia patients eligible for cytoreductive therapies in the US and Canada
Abstract Introduction: Essential thrombocythemia (ET) is a rare type of myeloproliferative neoplasm (MPN) characterized by elevated platelet...
Multiple myeloma in adolescents and young adults (AYA): A comparative analysis of global and u.S.a, epidemiological trends, risk factors, and projections (1990–2040)
Abstract Introduction: Multiple myeloma (MM), historically considered a malignancy of older adults, is increasingly bein...
Clinical characteristics and outcome of diffuse large B-cell lymphoma: Real world data from Saudi Arabia
Abstract Background: Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma both globa...
Early TCR diversity and recipient stem-cell persistence predict relapse and reveal therapeutic targets after allogeneic transplantation
Abstract Introduction Standard treatment for high and intermediate risk acute myeloid leukemia (AML) includes induction chemotherapy followe...
Serum neurofilament light chain (NfL) as a biomarker for chemotherapy-induced peripheral neuropathy (CIPN) in pediatric acute lymphoblastic leukemia (ALL)
Abstract CIPN is a relatively common complication in children and adolescents undergoing treatment for ALL and it is mostly associated with...
CD34 selected stem cell boost provides robust outcomes in patients with poor graft function
Abstract Background: Allogenic stem cell transplantation (SCT) is a curative option in several hematological malignancies. However, patients...
Efficacy and safety of benralizumab in patients with hypereosinophilic syndrome: Results from the Phase 3 natron study
Abstract Background: Hypereosinophilic syndrome (HES) is a group of rare, heterogeneous disorders characterized by persistent hypereosinophi...
Trial in progress: A phase I/ib dose-finding study of ropeginterferon alfa-2b (P1101) in patients with cutaneous T-cell lymphoma (CTCL)
Abstract Background and Significance: Cutaneous T-cell lymphoma (CTCL) is a rare, incurable non-Hodgkin lymphoma characterized by progressiv...
ST6GALNAC4 promotes DLBCL progression by regulating ldha sialylation to enhance glycolysis and lactate production
Abstract Targeted epigenetic modification has emerged as a critical strategy in cancer therapy, showing promising therapeutic potential in s...
Synergistic antitumor effects and mechanisms of KPT-330 combined with venetoclax in Acute Myeloid Leukemia
Abstract Introduction The venetoclax-azacitidine (VA) regimen is a standard frontline therapy for elderly or chemotherapy-ineligible patient...
Evaluation of clonal hematopoiesis and the clinical impact of myeloid somatic mutations on hematologic and marrow parameters in patients without diagnosed malignancy: A single center retrospective cohort study.
Abstract Background The increasing use of next-generation sequencing (NGS) has identified a subset of patients who harbor somatic mutations...
The NLP protein is a novel regulator of G2-m Phase of the cell cycle critical for proliferation of human peripheral T-cell lymphomas
Abstract Peripheral T-cell lymphomas (PTCL) are a diverse group of aggressive T- and NK-cell malignancies distinguished by differences in ce...
Establishment of a prognostic model for diffuse large B-cell lymphoma based on mitochondrial energy metabolism-related genes
Abstract Mitochondrial energy metabolism has emerged as a critical regulator of tumor progression and immune dynamics. However, its prognost...
RNA−binding protein FXR1 stabilizes receptor tyrosine kinase FGFR1 and enhances PI3K−Akt signaling to promote T−cell leukemogenesis
Abstract Introduction: T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy with poor five-year surviva...
Characterization of antecedent clonal hematopoiesis (CH) mutations in lymphoid and plasma cell neoplasms
Abstract Background: Premalignant CH pattern for myeloid malignancies is well established but the characteristics and pattern, if any, that...
Adult acute myeloid leukemia with NUP98 rearrangement benefits from targeted therapy and bone marrow transplantation
Abstract Introduction: Nucleoporin 98 (NUP98) rearrangement has been proposed as a type of acute myeloid leukemia (AML)...
Pulmonary vein thrombosis following bronchoscopic cryobiopsy: A case report
Abstract Pulmonary vein thrombosis (PVT) is a rare and often underdiagnosed condition typically associated with thoracic surgery, catheter a...
Updated meta-analysis of inhibitor development in previously untreated patients with severe Hemophilia A: Plasma-derived versus recombinant FVIII products
Abstract Background: Neutralizing inhibitors remain the major complication of replacement therapy in previously untreated patients (PUPs) w...
Lipid metabolism disorders and immune metabolic programming in patients with idiopathic multicentric Castleman disease
Abstract Idiopathic multicentric Castleman disease (iMCD) is a rare hematologic disorder characterized by lymphadenopathy, with high heterog...
High levels of soluble TREM2 predict poor survival outcomes and facilitate the expansion of immunosuppressive monocytic-lineage cells in patients with DLBCL.
Abstract Introduction : Triggering receptor expressed on myeloid cells-2 (TREM2) is a surface receptor with anti-inflammatory properties, kno...
Pediatric Acute Myeloid Leukemia associated S100A9 promotes T cell dysfunction
Abstract Despite immunotherapy revolutionizing cancer treatment, myeloid malignancies have remained largely refractory to T cell-based strat...