Blood
Articles in this Issue
Blood and CSF metabolomics identifies tryptophan catabolism and polyamine synthesis as drivers of CAR T-cell-associated neurotoxicity
Abstract Background: Anti-CD19 chimeric antigen receptor (CAR) T-cell therapies have demonstrated durable responses and...
Role of ADAMTS13 and von Willebrand factor in pathogenesis of experimental preeclampsia in rats
Abstract Introduction: Preeclampsia, a serious complication of pregnancy that occurs at ≥20 weeks of gestation, is characterized primarily b...
Trends in mortality due to hematological malignancies among diabetic patients aged 25 and older in the u.S. (1999–2023): A 24-year CDC wonder database analysis
Abstract Introduction: Hematologic malignancies—including multiple myeloma, non-Hodgkin lymphoma, and leukemia—are more...
Ibrutinib plus rituximab leads to superior progression-free and overall survival to FCR in previously untreated CLL: Results of the Phase III NCRI FLAIR trial
Abstract Introduction: The most effective chemoimmunotherapy (CIT) in previously untreated CLL is the combination of flu...
Outcomes of arthroplasty in persons with hemophilia: A survey of Medicare data
Abstract Background: The most common bleeding manifestation of hemophilia is bleeding into major joints. A significant percentage of persons...
The clinical trials landscape in chronic lymphocytic leukemia: A systematic review of control arm adequacy
Abstract Background: Over the last decade, the standard of care (SOC) for previously untreated chronic lymphocytic leukemia (CLL) has transi...
Upfront maintenance therapy improves the prognosis of patients with diffuse large B-cell lymphoma in the era of novel agents: A multicenter retrospective study
Abstract Introduction Current first-line R-CHOP therapy achieves a cure in only 50–70% of diffuse large B-cell lymphoma (DLBCL) patients, wi...
Utilisation of machine learning algorithms to predict relapse risk following allogeneic stem cell transplantation (alloSCT) for patients with myeloid malignancies
Abstract Background: Disease relapse remains the primary cause of treatment failure following alloSCT for acute myeloid leukaemia (AML) and...
BCMA-targeted CAR T cells for multi-refractory primary immune thrombocytopenia: A pilot study
Abstract Background:Primary immune thrombocytopenia (ITP) is a bleeding disorder primarily driven by pathogenic anti-platelet autoantibodies...
Tazemetostat in Relapsed/Refractory follicular lymphoma and DLBCL: A systematic review of clinical trials
Abstract Introduction Tazemetostat, an EZH2 inhibitor, received FDA approval (2020) for third-line treatment of relapsed...
Next-generation sequencing as a powerful tool for measurable residual disease assessment in pediatrics: Identifying time points of true remission
Abstract Introduction Next-generation sequencing (NGS) is a sensitive tool for measurable residual disease (MRD) detection, particularly in a...
Trial in progress: Romiplostim N01 combined with immunosuppressive therapy in patients diagnosed with non-severe aplastic anemia, a Phase II study
Abstract Background Aplastic anemia (AA) is a bone marrow failure syndrome characterized by pancytopenia and hypocellula...
Inhibition of NSD2 in t(4;14) myeloma induces changes in mitochondrial priming
Abstract Introduction: Myeloma patients with the t(4;14) subtype are classified as high-risk with lower progression free and overall surviva...
Monoclonal light chain glycosylation is associated with evolution of incidental MGUS
Abstract Introduction: Diagnostic delay remains a challenge in Multiple myeloma (MM), despite evidence that early detect...
Umbilical cord blood microtransplantation as consolidation therapy for elderly patients with newly diagnosed Acute Myeloid Leukemia: A single-center randomized controlled trial
Abstract Background:Acute myeloid leukemia (AML) is a common hematologic malignancy in adults, with a particularly poor prognosis in elderly...
Single-cell transcriptomics reveal long non-coding RNA dysregulation in PPP1R15B-EIF2A axis impairing erythroid maturation in myelodysplastic syndromes
Abstract INTRODUCTION: Anemia is the main clinical manifestation of low-risk myelodysplastic syndromes (MDS), reflecting ineffective erythro...
Real-world analysis of ICI-associated HLH reveals early mortality despite standard interventions
Abstract Introducion: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by excessive i...
Care quality for patients with sickle cell disease and associations with negative descriptors in the electronic medical record
Abstract Introduction We previously demonstrated that patients with sickle cell disease (SCD) have higher odds of negative descriptors in th...
Concurrent loss of TP53 and CDKN2A with tetraploidy predicts richter transformation and poor prognosis in chronic lymphocytic leukemia
Abstract Background: Richter transformation (RT) can occur in 2-20% chronic lymphocytic leukemia (CLL) patients and has a poor prognosis wit...
Immune checkpoint Inhibitors' impact on outcomes of relapsed and refractory Hodgkin lymphoma: A real-world study
Abstract Background Immune checkpoint inhibitors (ICI) have become central to treating relapsed or refractory classical Hodgkin lymphoma (R/R...
Real-world survival, cognitive and health-related quality of life outcomes of methotrexate/ifosfamide plus whole brain radiotherapy for newly diagnosed primary central nervous system lymphoma
Abstract Background: Outcomes for primary central nervous system lymphoma (PCNSL) have been improved with high-dose methotrexate (HD-MTX)/Th...
Accurate and automated multi-center TCD velocity analysis using natural language processing
Abstract Background: Up to 10% of US children with sickle cell disease (SCD) develop abnormal transcranial Doppler (TCD) velocities, indicat...
Probiotics supplementation ameliorates bone marrow mesenchymal stem cells injury via IFN-I/STAT1 signaling pathway in immune thrombocytopenia during pregnancy
Abstract Introduction Immune thrombocytopenia (ITP) affects approximately 1 to10 per 10,000 pregnancies. It showed that bone marrow mesenchy...
Efficacy and safety of venetoclax in high-risk Relapsed/Refractory AL amyloidosis: A systematic review and meta-analysis
Abstract Introduction AL amyloidosis is a rare plasma cell disorder characterized by the deposition of misfolded light chain proteins in org...
Rapid initiation of cyclosporine and eltrombopag ahead of definitive treatment decreases autoimmunity and expedites marrow recovery in a prospective phase II trial
Abstract Introduction: Severe aplastic anemia (SAA) is characterized by pancytopenia and an empty marrow. Due to multiple diagnostic procedu...