Blood
Articles in this Issue
Dual anti-HLH and antitumor efficacy of golidocitinib in relapsed/refractory PTCL-associated hemophagocytic lymphohistiocytosis: A retrospective safety and activity analysis
Abstract Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome driven by cytokine storms (e....
GVHD intel 1.0: A scalable, HLA-enhanced machine learning model for predicting acute and chronic GVHD
Abstract Background: Graft-versus-host disease (GVHD) remains the leading cause of non-relapse morbidity and mortality in allogeneic hematop...
Real-world comparative outcomes of pola-R-CHP versus R-CHOP in patients with diffuse large B-cell lymphoma
Abstract Introduction: The emergence of novel immunotherapies has transformed the treatment landscape for hematological malignancies such as...
The novel ims / IMWG high-risk multiple myeloma criteria may omit individuals with renal impairment and adverse disease prognosis
Abstract Background: Renal impairment (RI) is common in newly diagnosed multiple myeloma (NDMM). Since serum β2-microglobulin (sb2m) is a mar...
Ropeginterferon alfa-2b in 248 patients with polycythemia vera: Results from the italian cohort of a prospective, non-interventional, post-authorization study (ROPEG-PV)
Abstract Introduction: Ropeginterferon alfa-2b (Ropeg) was approved in Europe (2019) and in the US (2021) for treating polycythemia vera (PV...
Association of factor VIII inhibitors with genetic variants implicated in immune dysregulation
Abstract Introduction: Congenital hemophilia A (HA) is a severe bleeding disorder that results from the deficiency of coagulation factor VII...
Efficacy and safety of romiplostim N01 for second-line treatment of pediatric immune thrombocytopenia: A multicenter prospective observational study
Abstract Background: Pediatric immune thrombocytopenia (ITP) is an autoimmune disorder characterized by thrombocytopenia and an increased ri...
Pneumocystis jirovecii pneumonia in patients with hematologic malignancy: Risky business, but for whom?
Abstract Background: Pneumocystis jirovecii pneumonia (PJP) is a serious respiratory infection that can have significant...
Blast clearance dynamics and time to response across IDH1- and IDH2-mutated AML
Abstract Background: Isocitrate dehydrogenase (IDH) mutations are frequently implicated in the development of acute myel...
Interim analysis of the phase II study of glofitamab, lenaliomide and venetoclax (GLOVe) in untreated patients w/ high-risk mantle cell lymphoma. response and safety outcomes after the completion of stage 1 of 2 enrollment.
Abstract Background: Mantle Cell Lymphoma (MCL) has no established standard of care (SOC) in the front-line (1L) setting. Recent studies - T...
Safety and efficacy of INCA033989, a novel first in class mutant calreticulin-specific monoclonal antibody, in patients with essential thrombocythemia
Abstract Background: Essential thrombocythemia (ET) is a myeloproliferative neoplasm with increased risk of thrombosis, hemorrhage, and tran...
Initial treatment of chronic lymphocytic leukemia with low-dose high-frequency rituximab followed by addition of acalabrutinib
Abstract Introduction: Rituximab is effective at removing circulating CLL cells by inducing antibody-dependent cellular phagocytosis (ADCP)....
CAR-T cells co-targeting BCMA and CD19 in RRMM: Results from the UKMRA Phase 1 MCARTY trial in relapsed refractory multiple myeloma
Abstract Introduction: BCMA directed CAR-T cell therapy for multiple myeloma (MM) shows promise, but relapses continue to occur despite deep...
Optimizing ELN 2022: Developing and validating a dynamic prognostic model for AML using platelet change rates and MRD kinetics
Abstract Background Acute myeloid leukemia (AML) shows significant clinical and molecular diversity[1]. The ELN 2022 ris...
Raising the bar in maternofetal hematology: Cost-effectiveness of iron deficiency screening in pregnancy across ferritin-based thresholds
Abstract Introduction: Iron deficiency (ID) is among the five leading causes of years lived with disability in women of reproductive age wor...
TCL1A polymorphism predicts AML progression in myeloid neoplasms
Abstract Background: Clonal hematopoiesis is driven by somatic mutations in hematopoietic stem cells that confer their fitness advantage and...
Circulating immune profile in patients with amyloidosis
Abstract Introduction Although both light-chain (AL) and transthyretin (ATTR) amyloidosis involve accumulation of misfolded proteins in one...
Validation of the boscore model for predicting invasive mold disease in Chinese patients with hematological malignancies undergoing chemotherapy: A single-center retrospective study
Abstract Background: Patients with hematological malignancies (HM) are at high risk of invasive mold disease (IMD) due to chemotherapy-induc...
Clinical characteristics of early mortality and critical illness in acute promyelocytic leukemia patients
Abstract Results: Among the 408 newly diagnosed APL patients, 27 experienced early deathand the early mortality rate was 62%. The median tim...
Impact of metformin on the incidence of thrombotic events in older patients with polycythemia vera and essential thrombocythemia in the United States
Abstract XM, NP co-senior authors Background Patients (pts) with Philadelphia chromosome negative myeloproliferative neo...
Clpx plays pleiotropic roles in heme synthesis and erythropoiesis
Abstract Differentiating red cells synthesize large quantities of heme for hemoglobin production, requiring tight coordination between mitoc...
Long-term outcomes with emicizumab prophylaxis in patients with hemophilia a in China
Abstract Introduction: Emicizumab, a bispecific monoclonal antibody that bridges activated factor IX and factor X, has emerged as an effecti...
Partial splenic embolization to manage thrombocytopenia in cancer patients: Case series and review of the literature
Abstract Introduction Thrombocytopenia is a common complication of cancer and its management (Liebman, 2014). Alleviatin...
Loss of transcription factor myb drives an immune differentiated megakaryocyte phenotype
Abstract Bulk and single cell RNA-sequencing (RNA-seq) of lung and bone marrow (BM) megakaryocytes (Mks) revealed the transcription factor M...
Preliminary results of a first-in-human, Phase 1 study of GLB-002, a novel molecular glue degrader of IKZF1/3, in patients with relapsed or refractory non-Hodgkin lymphoma
Abstract Introduction GLB-002 is a novel cereblon E3 ubiquitin ligase modulator selectively targeting Ikaros (IKZF1) and Aiolos (IKZF3) for...