Blood
Articles in this Issue
Health care professionals (HCPs) perspectives on treatment and management of light chain (AL) amyloidosis: An international cross-sectional survey study
Abstract Introduction: Light chain (AL) amyloidosis is a rare multi-systemic disease where abnormal proteins in plasma cells misfold and cre...
Momelotinib inhibition of JAK/STAT in a mouse JAKV617F myelofibrosis model showed concurrent activation of p-ERK and p-AKT which was reversed by combination therapy using LP-182, a novel MEK/PI3K/mTOR inhibitor
Abstract Introduction: Most cases of myelofibrosis (MF) arise from constitutive activation of the JAK/STAT signaling pathway in hematopoieti...
Vitamin d and other micronutrients influence prognosis of patients with non-Hodgkin lymphoma (NHL)
Abstract Introduction: Lymphocytes, including lymphoma cells require many micronutrients to grow and differentiate properly. Vitamin D is on...
Long-term rusfertide treatment in polycythemia vera: Initial results from the phase 2 THRIVE extension study
Abstract Background: Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by red blood cell overproduction. In the phase 2 R...
ASXL1 mutations are associated with adverse outcomes in european leukemianet (ELN) 2024 favorable risk patients with Acute Myeloid Leukemia (AML) treated with venetoclax (VEN) containing low-intensity therapy (LIT)
Abstract Background ASXL1 mutation (mut) is frequent in myeloid malignancies, and has adverse prognostic implications in AML treated with int...
From deficiency to competency: Strategies to strengthen classical hematology training across the United States
Abstract INTRODUCTION Classical hematology is a critical yet underemphasized component of hematology/oncology fellowship...
Next-day manufactured CD19 CAR-T cells exhibit superior persistence compared to conventional CAR-T therapy in R/R B-ALL
Abstract Introduction: Conventional CD19-directed CAR-T manufacturing requires 7–14 days, potentially delaying treatment and promoting T-cel...
NLRP3 inflammasome inhibition fails to prevent red blood cell lysis in PNH
Abstract Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated red blood cell (RBC) lysis due to a...
Artificial intelligence accelerates the identification of measurable residual multiple myeloma by flow cytometry
Abstract Background: Flow cytometry (FC) is widely utilized for the identification of measurable residual disease (MRD) in multiple myeloma...
Clinical impact and prognostic implications of concurrent light-chain amyloidosis in patients with POEMS syndrome: A single-center retrospective study
Abstract Background POEMS syndrome is an uncommon multisystem plasma cell disorder characterized by polyneuropathy, organomegaly, endocrinop...
Association between clonal mutations in Acute Myeloid Leukemia and novel fibrinolytic biomarkers
Abstract Introduction: Acute myeloid leukemia (AML) is characterized by dysregulated fibrinolysis, which leads to bleeding and thrombotic co...
Demographic and regional trends in aplastic anemia mortality among adults in the United States, 1999-2020: A retrospective study using CDC wonder data
Abstract Introduction: Global and historical data identify Aplastic Anemia as a high-risk disease with significant early mortality. Factors...
Outcomes of patients with Richter transformation (RT) treated with frontline chemoimmunotherapy (CIT) and BTK inhibitor (BTKi)
Abstract Background: Despite a typically indolent course observed in chronic lymphocytic leukemia (CLL), 2-8% of patients will develop an ag...
In Vivo transfer of CD4+ T cells reshapes CD8+ T cell differentiation trajectory in humans
Abstract Relative to donor CD8+ T cells, the recovery of CD4+ T cell populations is severely delayed following allogeneic hematopoietic stem...
EASIX-guided risk stratification of severe coagulopathy and early mortality among newly diagnosed acute myeloid leukaemia with APL-like phenotype
Abstract Introduction: Acute promyelocytic leukemia (APL)-like is a unique subgroup of non-M3 acute myeloid leukemia (AML), with a special C...
Optimizing outcomes and accessibility of matched sibling donor transplantation for severe hemoglobinopathies in low-resource settings
Abstract Allogenic HSCT remains the only curative approach for thalassemia major. We describe results of a cost-consciou...
Comparative efficacy of therapeutic interventions for thalassemia-induced osteoporosis: A network meta-analysis
Abstract IMPORTANCE Despite advancements in the management of thalassemia major (TM), osteoporosis remains a significant concern among patie...
Reducing premedication use with intravenous iron in the outpatient setting: A quality improvement project
Abstract Background: Early formulations of intravenous (IV) iron were associated with anaphylaxis and have since been removed from the marke...
An open-label, multi-center Phase 2 study to assess the safety and efficacy of burixafor (GPC-100) and propranolol with G-CSF for the mobilization of hematopoietic progenitor cells in patients with multiple myeloma
Abstract Background and Significance Autologous hematopoietic cell transplant (AHCT) is standard of care for multiple myeloma (MM) treatment...
The importance of autologous stem cell transplant (ASCT) in multiple myeloma treatment in the lack of novel therapies
Abstract Background: Multiple Myeloma (MM) is an incurable disease; however, its management has evolved significantly in...
Radiotherapy consolidation post-autologous stem cell transplant in Relapsed/Refractory aggressive non-Hodgkin lymphoma improves progression-free and overall survival in patients with partial but not complete metabolic response pre-transplant
Abstract Background: Salvage chemotherapy followed by autologous stem cell transplant (ASCT) is a potentially curative procedure for patient...
Simplified frailty score for patients with multiple myeloma undergoing autologous stem cell transplant
Abstract Background: Autologous stem cell transplant (autoHCT) is standard of care for eligible patients with newly diagnosed multiple myelom...
Venetoclax plus mitoxantrone hydrochloride liposome and Azacitidine As first-line treatment for adults with Acute Myeloid Leukemia
Abstract Background The standard “3+7” regimen (idarubicin/daunorubicin combined with cytarabine, IA/DA) remains the cornerstone of first-lin...
Prophylactic G-CSF (granulocyte colony-stimulating factor) in AML (Acute myeloid leukemia) induction: A meta-analysis dispelling relapse concerns and reinforcing supportive benefit
Abstract Introduction: Granulocyte colony-stimulating factor (G-CSF) is routinely used to reduce chemotherapy-induced ne...
Zanubrutinib combined with anti-CD19 CAR-T cell therapy in relapsed and refractory B-cell lymphoma
Abstract Background The response rate and long-term survival of anti-CD19 chimeric antigen receptor (CAR) T-cell therapy...