Blood
Articles in this Issue
Demographic and laboratory features of monoclonal gammopathy of undetermined significance (MGUS) subtypes in a single-center cohort
Abstract Introduction: Monoclonal gammopathy refers to the presence of monoclonal immunoglobulins (M proteins) or free light chains (FLCs) p...
Hesperadin, an aurora B kinase inhibitor, synergizes with chidamide to suppress T-cell acute lymphoblastic leukemia by targeting c-MYC
Abstract Background: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of immature T cells, frequently driven by MYC o...
Impact of pre-allogeneic stem cell transplantation (SCT) disease characteristics, therapy, and response on post-SCT outcomes in higher risk myelodysplastic syndromes
Abstract Introduction: Allogeneic stem cell transplantation (SCT) is the only known curative treatment in higher-risk (HR) myelodysplastic s...
Promising response rates and manageable safety with mosunetuzumab plus lenalidomide (Mosun-Len) in patients with relapsed/refractory (R/R) follicular lymphoma (FL): US extension cohort from the Phase III CELESTIMO study
Abstract Background: CELESTIMO (NCT04712097) is a randomized, multi-center, Phase III study evaluating the efficacy and safety of Mosun-Len...
Immunotherapy without or with low-intensity chemotherapy versus standard chemotherapy as first-line treatment for newly diagnosed b-ALL patients: A propensity score-matched study
Abstract Introduction： B-cell acute lymphoblastic leukemia(B-ALL) is a common malignant tumour of the blood system.With a high frequency of...
Serum BCMA (sBCMA) levels in plasma cell dyscrasias: Insights from a south Indian prospective study
Abstract Introduction: Serum B-cell maturation antigen (sBCMA) is an emerging non-invasive biomarker for assessing tumor...
Mechanisms of chemotherapy resistance driven by Mecom overexpression
Abstract Acute myeloid leukemia (AML) is an aggressive hematologic malignancy that causes >11,000 deaths per year in the United State...
First-line salvage therapies in relapsed/refractory large B-cell lymphoma after second- or third-line CD19-directed CAR T-cell therapy
Abstract Introduction: CD19-directed CAR T-cell (CAR-T) therapy is increasingly deployed in earlier lines of treatment for relapsed/refractor...
Trial in progress: A phase I study evaluating the safety of cirtuvivint (CIRT) as monotherapy and in combination with ASTX727 in patients with myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML)
Abstract Background and Signficance Patients with relapsed and/or refractory (R/R) MDS or AML have poor outcomes. Outcomes after resistance t...
From unexplained cytopenias to clonality: Diagnosing T-cell large granular lymphocytic leukemia in rheumatoid arthritis via integrated molecular profiling
Abstract Introduction: Persistent cytopenias in patients with rheumatoid arthritis (RA) pose significant diagnostic challenges and are frequ...
Real-world characteristics and treatment patterns of patients with myelodysplastic syndromes treated with luspatercept in Puerto Rico
Abstract Background: Myelodysplastic syndromes (MDS) are a rare heterogenous group of hematopoietic stem cell malignanci...
Incidence of second primary malignancies (SPMs) following bispecific antibody (BsAb) therapy for lymphoid malignancies: A descriptive analysis of clinical trials
Abstract INTRODUCTION Bispecific antibodies (BsAbs) have emerged as transformative therapies for hematologic malignancie...
Talquetamab outcomes in relapsed/refractory myeloma with extramedullary and paraskeletal soft tissue plasmacytomas
Abstract Background: Talquetamab (Talq), a GPRC5D-targeting bispecific antibody, shows promising activity in relapsed/refractory multiple my...
Serum free light chain escape before IMWG progression: A predictive marker and a therapeutic opportunity
Abstract Background Serum free light chains (sFLC) exhibit greater sensitivity than protein electrophoresis (PEP) and immunofixation electrop...
Adult-onset non-langerhans histiocytosis with multisystem involvement and sustained remission on immunochemotherapy
Abstract Histiocytosis refers to a group of rare disorders characterized by the proliferation and accumulation of cells derived from the mon...
The brazilian registry of hematopoietic cell transplantation and cellular therapy: A MODEL of collaborative progress and DATA management leadership
Abstract Background: The establishment of the Brazilian Registry of Hematopoietic Cell Transplantation and Cellular Therapy (RBTCH-TC) in 20...
An analysis of the cerebral spinal fluid metabolome during intensive chemotherapy and its association with depressive symptoms in children with acute lymphoblastic leukemia
Abstract Improvements in pediatric acute lymphoblastic leukemia (ALL) treatment have led to five-year survival rates exceeding 90%. Despite...
Comparative analysis of characteristics and outcomes in CD5+/FMC7+ lymphoproliferative disorders and classic CLL immunophenotype patients.
Abstract Introduction: While FMC7, an epitope on CD20, expression is frequently seen in mantle cell lymphoma (MCL), it i...
Prophylactic transfusion in pregnant in women with sickle cell disease (ProTIP)
Abstract Background and Significance: Sickle cell disease (SCD) affects pregnancy outcomes with high maternal and fetal morbidity rates. Ove...
Development and characterization of a potent and selective BLIMP1 protac as a novel, first-in-class therapy for multiple myeloma
Abstract Introduction: B lymphocyte-induced maturation protein-1 (BLIMP1) encoded by the PRDM1 gene, is a transcriptional corepressor essent...
Implementation and utility of measurable residual disease (MRD) testing for multiple myeloma patients at a VA medical center
Abstract Measurable residual disease (MRD) testing in myeloma has been shown to be a strong prognostic marker for progression-free and overa...
Machine learning-powered integration of global proteomics and ex vivo sensitivity unveils a protein signature predictive of treatment success to AML therapy: Validation in patients treated with FHD-286, a SMARCA2/4 dual inhibitor
Abstract Acute myeloid leukemia (AML) has a 33% 5-year survival rate, and few new therapies have made a meaningful impact on the overall pro...
Acute Myeloid Leukemia: Diagnosis and treatment at a tertiary center in cochabamba - Bolivia.
Abstract Background Acute myeloid leukemia (AML) is a clinically and biologically complex disease. During the last decade, classification, p...
Comprehensive multiproteomic analysis reveals an inflammatory phenotype in immune aplastic anemia characterized by broad activation of antigen presenting cells and t helper/cytotoxic 1.17 immune responses
Abstract Background: Immune Aplastic Anemia (AA) is an autoimmune disease where hematopoietic stem and progenitor cells (HSPC) are destroyed...
6-gingerol ameliorates murine gastrointestinal graft-versus-host disease by inhibiting pyroptosis of intestinal epithelial cell
Abstract Aims Gastrointestinal graft-versus-host disease (GI-GvHD) is a major cause of post-allo hematopoietic stem cell...