Blood
Articles in this Issue
Leveraging an integrated single cell atlas to understand perinatal bone marrow development
Abstract The perinatal period is an emerging yet understudied stage of hematopoietic ontogeny. It has been shown that the murine bone marrow...
Impact of extranodal involvement in stage I aggressive B-cell lymphoma in the rituximab era: An individual patient data meta-analysis of two Phase III dshnhl/GLA trials
Abstract Background: The prognostic impact of extranodal stage I large B-cell lymphoma (LBCL) in the rituximab era remains unclear, and the...
Impact of extrinsic heme on adoptive T cell therapy
Abstract Chimeric Antigen Receptor (CAR) T cell fitness can be significantly influenced by the metabolic microenvironment. As CAR T cells ar...
Impact of FMC7 expression on baseline characteristics and outcomes in CLL patients treated with upfront BTKi monotherapy.
Abstract Introduction: Expression of FMC7, an epitope of CD20, can be detected in several CD5+ lymphoproliferative disor...
Impact of conditioning regimen on outcomes of adolescents and young adults AML patients undergoing HCT in complete remission, with transplant conditioning intensity score of 3.5-4.0. a study from the acute leukemia working party of the european society for blood and marrow transplantation.
Abstract The optimal myeloablative conditioning regimen for adolescents and young adults (AYA) with acute myeloid leukaemia (AML) is current...
Emergence of new somatic mutations in CML patients optimally responding to tyrosine kinase inhibitor therapy: Proposal of long-term genomic monitoring
Abstract Introduction Next-generation sequencing (NGS) has revealed a broader range of somatic mutations in chronic myeloid leukemia (CML) pa...
Trends and disparities in anemia and cardiac arrest-related mortality in adults aged ≥ 25 years in the United States from 1999 to 2023: A CDC wonder database analysis
Abstract Introduction: Anemia and cardiac arrest are both common diseases in the United States, and when concomitant, they accelerate morbid...
Clonal heterogeneity of acute myeloid leukemia under nutrient and chemotherapy stress
Abstract Background and Objective: Acute myeloid leukemia (AML) is a genetically heterogeneous disease, but even isogenic leukemic populatio...
CHOP combined with linperlisib or chidamide may decrease the risk of mortality of monomorphic epitheliotropic intestinal T-cell lymphoma: A single-center cohort study
Abstract Background: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is an extremely rare and highly aggressive subtype of pe...
Genomic profiling in CLL patients after BTK inhibitor progression identifies enrichment of mutations in MAPK pathway and epigenetic regulators
Abstract Introduction: Although therapies targeting Bruton Tyrosine Kinase (BTK), either as monotherapy or in combination have revolutionize...
Sapport: A specialty training program for advanced practice providers to increase knowledge and access to care for people living with sickle cell disease
Abstract Introduction: The classical hematology community has increasingly turned to advanced practice providers (APPs) to fill gaps in care...
In-depth, quantitative characterization of important regulators and predictive biomarkers for CAR T-cell therapy induced toxicities in a clinical cohort
Abstract Background: CAR T cells targeting B cell maturation antigen (BCMA) and CD19 achieve high response rates in B cell malignancies.Howe...
Orca-T improves chronic graph-versus-host disease free in patients with a broad range of demographic and clinical variables: Results of randomized, Phase 3 trial
Abstract BACKGROUND Orca-T is an investigational allogeneic T-cell immunotherapy using purified donor regulatory T cells to prevent graft-ve...
Interim Phase 1 study of sequential CD7 CAR T-cell therapy and haploidentical HSCT without GVHD prophylaxis in patients with Relapsed/Refractory CD7-positive hematologic malignancies
Abstract Background: CD7 chimeric antigen receptor (CAR) T-cell therapy has recently emerged as a promising strategy to induce remission of...
Minimal residual disease dynamics in post-transplant patients with newly diagnosed multiple myeloma who received daratumumab plus lenalidomide versus lenalidomide alone as maintenance therapy in the auriga study
Abstract Introduction:The standard of care following autologous stem cell transplant (ASCT) for patients (pts) with newly diagnosed multiple...
Clinical pharmacology strategies to support dose optimization of the recommended Phase 2 dose regimen of JNJ-5322, a BCMA×GPRC5D×CD3 trispecific antibody, in Relapsed/Refractory multiple myeloma
Abstract Introduction: JNJ-5322 is a next-generation trispecific antibody that contains novel B-cell maturation antigen (BCMA), G protein–cou...
Impact of autoimmune hemolytic anemia on prognosis in chronic lymphocytic leukemia patients: A comprehensive retrospective analysis
Abstract Background: Autoimmune hemolytic anemia (AIHA) complicates 5%-10% of chronic lymphocytic leukemia (CLL) cases, significantly worsen...
Prophylactic immunoglobulin supplementation for infection prevention in multiple myeloma: An updated systematic review and meta-analysis
Abstract Introduction: Patients with multiple myeloma (MM) have an increased risk of infection secondary to hypogammaglobulinemia, due to my...
Peripheral blood B-cell early regeneration predicts clinical relapse and guides preemptive therapy after CAR-T treatment in acute lymphoblastic leukemia
Abstract Background: Relapsed/refractory acute B lymphoblastic leukemia (R/R B-ALL) has a poor prognosis and low overall survival rate. Some...
Efficacy of acalabrutinib in treatment-naive Mantle Cell Lymphoma: A systematic review and meta-analysis
Abstract Background: Mantle cell lymphoma (MCL) is a rare and typically aggressive subtype of non-Hodgkin's lymphoma. While MCL is largely i...
Integrative analysis of the tumour immune microenvironment of breast implant-associated anaplastic large cell lymphoma using multi-omics
Abstract Background Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is a recently identified T cell lymphoma that develop...
Artificial intelligence enhanced prognostication in rare Acute Myeloid Leukemia subtypes with BCR::ABL1 and inv(3)/t(3;): A systematic review
Abstract Background: Rare AML subtypes, such as AML with BCR::ABL1 fusion gene and Inversion(3)/translocation (3;3) [inv...
Efficacy and safety profile of inaticabtagene autoleucel in Chinese patients with Philadelphia chromosome-positive b-ALL: Insights from real-world data
Abstract Introduction Inaticabtagene autoleucel (Inati-cel) featuring a CD19 single-chain variable fragment derived from an HI19a clone and...
Real-world survival outcomes following allogeneic hematopoietic cell transplantation in peripheral T-cell lymphomas: A Florida multi-institutional cohort study
Abstract Introduction: Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of aggressive lymphoid malignancies characterized by hig...
Pharmacological CD206 blocking attenuates cell-free hemoglobin-induced liver damage in sickle cell disease
Abstract Introduction: Hemolysis and accumulation of cell-free hemoglobin (Hb) are major pathophysiological complications associated with si...