Blood
Articles in this Issue
Diffuse large B cell lymphoma in Brazil: Understanding the patient journey to improve healthcare assistance.
Abstract Background Diffuse Large B-cell Lymphoma not otherwise specified (DLBCL-NOS) is the most common type of non-Hodgkin lymphoma (NHL)....
Real-world outcomes of venetoclax-based therapy vs intensive chemotherapy in older adults with newly diagnosed Acute Myeloid Leukemia
Abstract Title: Real-World Outcomes of Venetoclax-Based Therapy vs Intensive Chemotherapy in Older Adults With Newly Diagnosed Acute Myeloid...
Ivosidenib leads to durable responses in IDH1 mutated clonal cytopenias of undetermined significance: A phase II decentralized clinical trial
Abstract BACKGROUND Ivosidenib is an oral inhibitor of mutant isocitrate dehydrogenase type I (IDH1) currently approved for the treatment of...
Artificial intelligence system for delivering interactive and verifiable guideline-based clinical decision support in hematology
Abstract Background: Artificial Intelligence (AI) has shown great potential in enhancing clinical practice. Many medical societies, includin...
SLC7A11 suppresses ferroptosis via arginine metabolism and promotes tumor immune escape in acute lymphoblastic leukemia
Abstract Acute lymphoblastic leukemia (ALL) is a hematologic malignancy characterized by high heterogeneity. Despite advancements in treatme...
Biophysical characterization of red blood cells in sickle cell trait reveals heterogeneous and intermediate pathophysiological profiles
Abstract Introduction: Sickle hemoglobin (HbS) results from a single nucleotide substitution in the β-globin gene. Individuals with homozygo...
Neonatal platelets induce monocytes to a myeloid derived suppressor cell phenotype
Abstract Work by our lab and others have shown that compared to neonatal platelets, adult platelets are relatively enriched in both transcri...
Real-world vs. clinical trial data of belantamab mafodotin's ocular toxicities: A comparative analysis
Abstract Introduction: Belantamab mafodotin is an antibody-drug conjugate (ADC) that is used for treatment of relapsed/refractory Multiple M...
From mechanistic synergy to clinical breakthrough: Updated results from a phase II Trial of HD-MTX, selinexor, and zanubrutinib in CNS lymphoma
Abstract Background: Central nervous system lymphoma(CNSL) is an aggressive extranodal non-Hodgkin lymphoma, most commonly classified as diff...
Oral iptacopan demonstrates efficacy as salvage therapy for high-risk transplant-associated thrombotic microangiopathy: First real-world experience
Abstract Background: Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication after hematopoietic stem c...
Mosunetuzumab in combination with zanubrutinib is safe in patients with relapsed/refractory follicular lymphoma: Safety run-in results from the FIL-mozart Phase II study
Abstract Introduction Treatment of relapsed/refractory (R/R) follicular lymphoma (FL) is shifting toward chemo-free regi...
Budget impact analysis for sickle cell disease point-of-care testing in Mozambique
Abstract Background: Sickle cell disease (SCD) is a leading cause of under-five mortality and morbidity in Sub-Saharan Africa. Effective neo...
Reassessing pre-chemotherapy laboratory testing in R-CHOP: Are we doing too much?
Abstract Background: Routine laboratory testing prior to chemotherapy administration is a cornerstone of hematology and oncology practice, a...
Building a kenyan framework for advanced multiple myeloma care: Outcomes from the 2024 national workshop
Abstract Background: Kenya faces significant gaps in multiple myeloma (MM) management, with available data (likely underreported) indicating...
Epidemiology and clinical characteristics of idiopathic multicentric castleman disease in Spain (ARCANA study): Prevalence cohort
Abstract Background Idiopathic multicentric Castleman disease (iMCD) is a rare, heterogeneous lymphoproliferative disorder affecting multipl...
Variances in patient reported experiences with shared decision-making by biological sex in patients with diffuse large B-cell lymphoma (DLBCL) – an analysis from the lymphoma coalition 2024 global patient survey on lymphomas and CLL
Abstract Introduction Shared decision-making (SDM) remains a key aspect of the patient-centred care paradigm in patients with lymphomas and...
RESHAPE: A non-interventional study of real-world treatment patterns and outcomes across age groups in people with severe hemophilia A in Latin America, Eastern Europe, Africa, Asia, and the Middle East
Abstract Background: Detailed treatment outcomes data in people with congenital hemophilia A (PwHA) outside North America, Western Europe, a...
Impact of obesity on survival outcomes in Acute Myeloid Leukemia patients treated with hypomethylating agents: A retrospective multicenter cohort study using real-world data
Abstract Background Obesity is a growing global health concern and has been associated with worse outcomes in various malignancies. However,...
Low-dose chemotherapy for induction in pediatric AML: Retrospective outcome analysis across expanded cohorts
Abstract Background: Our phase 3 randomized trial (CALSIII-AML18; n = 497) previously demonstrated non-inferior complete remission (CR/CRi)...
Validation of the High-Risk Consensus Genomic Staging System in Newly Diagnosed Multiple Myeloma
Abstract Introduction: Current identification of high-risk Multiple Myeloma (HRMM) primarily relies on the Revised International Staging Sys...
Machine-learning-augmented prediction of tumor metabolic burden and survival in multiple myeloma using clinical indicators
Abstract Background:PET-CT is a powerful imaging tool that can provide a detailed display of the lesion distribution, quantity, size and met...
Successful fertility preservation during curative therapy in female adolescent sickle cell anemia patients
Abstract Introduction: Sickle cell anemia (SCA) is a life limiting disease characterized by vasoocclusive episodes. Pati...
Transfusion independence in thalassemia patients after failure of gene therapy or with hemoglobin h constant spring and hb e using luspatercept: A case series
Abstract Background: Individuals with thalassemia who depend on blood transfusions to maintain adequate hemoglobin levels are at high risk o...
Long term outcomes of ET and PV patients after clinical trial treatment with interferon alfa
Abstract Background Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative neoplasms (...
Hematologic neoplasms and hypertension: National trends and associations in the United States, 1999–2023 — a CDC wonder analysis
Abstract Background: Hypertension is a major contributor to cardiovascular disease and a common comorbidity in patients with hematological c...