Blood
Articles in this Issue
Bone marrow adipose tissue is enriched in multiple myeloma cells
Abstract Introduction The role of the bone marrow microenvironment in multiple myeloma (MM) pathogenesis, progression an...
Isatuximab (Isa) plus lenalidomide (R), Bortezomib (V), and dexamethasone (d) (Isa-RVd) as induction therapy in transplant-eligible patients (pts) with newly diagnosed multiple myeloma (NDMM): Primary analysis of parallel phase 2 studies by the Dana-Farber Cancer Institute (DFCI) and Cancer Trials Ireland (CTI)
Abstract Background: RVd is a standard-of-care first-line regimen for pts with NDMM, regardless of eligibility for autologous stem cell trans...
Longitudinal multiproteomic analysis reveals persistent underlying inflammation in acute graft-versus-host disease patients responding to corticosteroid treatment
Abstract Background: Acute graft-versus-host disease (aGvHD) is a severe immune complication that can occur following allogeneic hematopoiet...
Short-term fasting releases the hematopoietic brake to promote bone marrow erythropoiesis
Abstract Erythropoietin (EPO) and erythropoiesis-stimulating agents are primary treatments for anemia in chronic kidney disease. However, th...
Health-related quality of life in Chinese multiple myeloma patients treated with daratumumab-based regimens in real world: Exploratory analysis of the MMY4032
Abstract Background: MMY 4032 (ChiCTR2200055491) is a multicenter, non-interventional, observational registry study that evaluated the real-...
Zanubrutinib, rituximab, and high-dose methotrexate as first-line treatment in newly diagnosed primary central nervous system lymphoma （zana）: A prospective, single-arm study
Abstract Background Primary central nervous system lymphoma (PCNSL) is a rare, aggressive extranodal non-Hodgkin lymphom...
Clinical outcomes associated with opioid use disorder in hospitalized patients with venous thromboembolism
Abstract Introduction Opioid use disorder (OUD) is an emerging significant risk factor for inpatient complications, incl...
Single-cell RNA-seq uncovers that plerixafor can mobilize more monocyte progenitor cells and enhance the activating graft immune status in multiple myeloma autologous transplantation.
Abstract Background: Autologous Hematopoietic Stem Cell Transplantation (Auto-HSCT) is one of the most effective treatme...
Oral glucose tolerance test remains the gold standard for diagnosis of glucose metabolism disturbances in thalassemia patients
Abstract Introduction: In transfusion-dependent β-thalassemia (TDT), pancreatic iron overload may disturb the function of pancreatic β-cells...
Portal and hepatic vein thrombosis in patients with Philadelphia-negative myeloproliferative neoplasms (MPN) from 2016 to 2022 in a national inpatient cohort
Abstract Background: Splanchnic venous thrombosis (SVT) is a well-known complication in pts with Philadelphia-negative myeloproliferative ne...
JAK1/2 inhibition with ruxolitinb potentiates ex vivo activity of epcoritamab in primary CLL cells
Abstract Introduction Epcoritamab,a bispecific antibody targeting CD20 and CD3, has demonstrated promising clinical activity in chronic lymp...
Feasibility and safety of bispecific antibodies outpatient model in triple-refractory multiple myeloma patients in two Italian centers
Abstract The Italian scenario for triple-refractory multiple myeloma (MM) patients has recently started to undergo a radical revolution with...
Clinical study on the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor injection (PEG-rhG-CSF) in autologous hematopoietic stem cell mobilization for lymphoma - Results of interim analysis
Abstract Background: Both PEG-rhG-CSF and rhG-CSF are widely used in autologous hematopoietic stem cell mobilization for lymphoma. There is...
Comprehensive analyses of patient-reported outcomes from the phase 3 VERIFY study of rusfertide or placebo plus current standard of care for polycythemia vera
Abstract Background: Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) characterized by erythrocytosis that is often accompanied...
Combined biparatopic nanobody-based B cell maturation antigen chimeric antigen receptor T cell therapy and pomalidomide for relapsed or refractory multiple myeloma: In-vitro characterisation and phase 1 dose-escalation study
Abstract Background Relapsed or refractory multiple myeloma (RRMM) remains incurable with conventional therapies. Existing B cell maturation...
Increased yield of recurrent structural variants (SVs) in Ph-like B-cell acute lymphoblastic leukemia (B-ALL) using a streamlined clinical whole-genome sequencing (WGS) assay
Abstract Introduction Ph-like B-ALL is a poor-risk B-ALL subtype defined by gene expression signatures that resemble the BCR::ABL1-associate...
Validation of the international working group (IWG) 2023 criteria for clinical benefit in higher risk Myelodysplastic Syndromes (HR-MDS) using a large, international, randomized Phase 3 clinical trial dataset
Abstract Introduction: The IWG 2023 criteria for HR-MDS (Zeidan Blood 2023) emphasize clinically meaningful blood count recovery. While thes...
Single-cell transcriptomics of pediatric B-ALL bone marrow to determine mechanisms of durable CD19 CAR T cell persistence
Abstract Chimeric antigen receptor T cell (CAR T) therapy has revolutionized the treatment of relapsed/refractory B cell acute lymphoblastic...
Live imaging of human xenogeneic CART cells in a clinical trial of companion dogs with lymphoma
Abstract Chimeric antigen receptor T (CART) cell therapy is potentially curative in certain hematological malignancies, resulting in several...
The venetoclax combined with metronomic low-dose decitabine and interferon for preventing post-transplant relapse in high-risk MDS and AML patients
Abstract Background Post-transplant relapse remains a primary factor limiting long-term survival in high-risk myelodysplastic syndromes (MDS...
Higher baseline whole blood viscosity is associated with chronic SCD complications
Abstract Background Sickle cell disease (SCD) is an inherited group of hemoglobinopathies that result in the production...
Dasatinib enhances potency of a novel CD123 CAR against AML by improving cell fitness
Abstract Background: CD123, the interleukin-3 receptor alpha chain (IL-3Ra), is overexpressed in hematologic malignancies including acute my...
Post-transplant cyclophosphamide based GVHD prophylaxis in HLA-matched related and unrelated donor hematopoietic cell transplantation in adults with hematologic malignancies undergoing myeloablative conditioning: A CIBMTR analysis of 8,272 participants
Abstract Background: In BMT CTN 1703, post-transplant cyclophosphamide (PTCy)-based prophylaxis significantly improved GVHD-free, relapse-fr...
Optimization of stem cell fitness and mobilization using moderate transfusion and an oral anti-sickling agent in the sickle mouse model.
Abstract Ex vivo gene therapy (GT) can transform the lives of people with sickle cell disease (SCD). However, GT relies on mobilization of s...
Mitoxantrone hydrochloride liposome injection combined with thiotepa-busulfan-fludarabine (MTBF) as conditioning regimen in patients undergoing allogeneic hematopoietic stem cell transplantation for central nervous system leukemia:a single-center retrospective case-control study
Abstract Background：Limited data is available to guide the choice of non-TBI conditioning regimen for patients with central nervous system...